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Dive into the research topics where Isabel N. de Kantor is active.

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Featured researches published by Isabel N. de Kantor.


The Journal of Infectious Diseases | 1997

Nosocomial Spread of Human Immunodeficiency Virus-Related Multidrug-Resistant Tuberculosis in Buenos Aires

Viviana Ritacco; Marta Di Lonardo; Ana Reniero; Marta Ambroggi; Lucía Barrera; Alicia Dambrosi; N. C Isola; Isabel N. de Kantor

A steep upsurge of human immunodeficiency virus (HIV)-associated multidrug-resistant tuberculosis (MDR-TB) was recently observed at a referral treatment center in Buenos Aires City. Between January 1994 and June 1995, TB isolates resistant to at least five drugs were recovered from 101 of 272 HIV-infected inpatients. Highly resistant isolates from 77 patients underwent restriction fragment length polymorphism study with IS6110. After cross-contamination was eliminated, a single TB strain was found to have caused disease in 68 patients with a history of on-site exposure. The frequency of smear-positive pulmonary disease was higher among these patients than among non-MDR-TB HIV-infected patients (50/68 vs. 60/148, P < .001), and the 1-year survival was dramatically reduced (5/68 vs. 92/148). The strain involved in the outbreak was traced back to patients hospitalized in 1992. Institutional infection control policies were and may still be inadequate to contain the spread of TB among immunodepressed subjects, as is the case in other large urban hospitals in Argentina.


Pediatric Infectious Disease Journal | 1989

Detection of circulating antibodies to purified protein derivative by enzyme-linked immunosorbent assay: its potential for the rapid diagnosis of tuberculosis.

Lucía Barrera; Isabel Miceli; Viviana Ritacco; Gabriela Torrea; Beatriz Broglia; Roberto Botta; Calixto Pérez Maldonado; Narcisco Ferrero; Alberto Pinasco; Irene Cutillo; Margarita Cornejo; Elsa Prokopio; Isabel N. de Kantor

An enzyme-linked immunosorbent assay for detecting antibodies to purified protein derivative was evaluated as a rapid method for serodiagnosis of childhood tuberculosis. Its specificity for IgG antibodies was 0.98 as determined in 55 sera from nontuberculous children who showed no significant effect of previous Bacillus Calmette-Guérin vaccination on the production of specific antibodies. Results were negative in 29 of 33 (87.9%) tuberculin-positive children and in 18 of 20 (90.0%) contacts, none of whom had evidence of tuberculosis. The sensitivity of this test was 0.51 as determined in 49 sera from bacteriologically confirmed cases; 17 of 27 smear positive cases and 8 of 22 children with positive cultures were detected. Results were positive in 32 of 114 (28.1%) patients with a diagnosis of tuberculosis not confirmed by microbiology. Consequently whereas a negative result does not rule out tuberculosis, a positive result is a strong indication of the disease. The IgM antibody determination yielded much less discriminative results.


Archive | 1998

Tuberculosis Laboratory Procedures for Developing Countries

Isabel N. de Kantor; Adalbert Laszlo

Two of the main requirements for a successful National Tuberculosis Program (NTP) in developing countries have been clearly defined (1): 1. Government commitment to a tuberculosis (TB) program aiming at nationwide coverage, conceived as a permanent health system activity, integrated into the existing health structure with effective technical leadership from a central unit 2. Case detection and treatment follow-up based on bacteriological examinations Tuberculosis bacteriology—a fundamental element of the NTP—must interrelate closely with the administrative, epidemiological, and clinical components of the program. Bacteriological diagnostic services must be developed concurrently with the other activities of the NTP and should be integrated in the general health services of the country to attain maximum coverage (2).


Journal of Clinical Microbiology | 2007

Simultaneous Detection of Mycobacterium bovis and Mycobacterium tuberculosis in Human Cerebrospinal Fluid

Viviana Ritacco; Isabel N. de Kantor

In the April 2006 issue of the Journal of Clinical Microbiology , Shah et al. reported the simultaneous presence of Mycobacterium tuberculosis and Mycobacterium bovis in 22 human cerebrospinal fluid specimens ([5][1]). The method used to reveal the alleged coinfection was a novel nested PCR (N-PCR)


Tubercle | 1985

Culture of Mycobacterium tuberculosis from non-fixed sputum smears

Isabel N. de Kantor; N. C Isola

Smears prepared from sputum species were kept in the dark at 4 degrees C or at 20-25 degrees C. Cultures for mycobacteria were carried out on these smears 0, 4, 8, and 15 days later and the results compared with those of cultures made from the sputum specimen on the day of collection. The percentage of negative cultures from originally positive specimens was high, and use of the method is not considered advisable. There is an additional risk of infection for laboratory staff when handling unfixed smears.


Veterinary Microbiology | 2006

The importance of Mycobacterium bovis as a zoonosis

Charles O. Thoen; Philip A. LoBue; Isabel N. de Kantor


Veterinary Microbiology | 2006

An update on bovine tuberculosis programmes in Latin American and Caribbean countries

Isabel N. de Kantor; Viviana Ritacco


International Journal of Epidemiology | 1988

Evaluation of the Effectiveness of BCG Vaccination Using the Case Control Method in Buenos Aires, Argentina

Isabel Miceli; Isabel N. de Kantor; Diana Colaiacovo; Graciela Peluffo; Irene Cutillo; Roberto Gorra; Roberto Botta; Silvia Hom; H. G Ten Dam


Journal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Health | 1990

Further Evaluation of an Indirect Enzyme‐Linked Immunosorbent Assay for the Diagnosis of Bovine Tuberculosis

Viviana Ritacco; Lucía Barrera; A. Nader; E. Fliess; Isabel N. de Kantor


Journal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Health | 1987

Assessment of the Sensitivity and Specificity of Enzyme‐Linked Immunosorbent Assay (ELISA) for the Detection of Mycobacterial Antibodies in Bovine Tuberculosis

Viviana Ritacco; Isabel N. de Kantor; Lucía Barrera; A. Nader; Amelia Bernardelli; Gabriela Torrea; Francisco Errico; Enrique Fliess

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Viviana Ritacco

National Scientific and Technical Research Council

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Adalbert Laszlo

International Union Against Tuberculosis and Lung Disease

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N. C Isola

Pan American Health Organization

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H. G Ten Dam

World Health Organization

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Marta Ambroggi

University of Buenos Aires

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Martha Di Lonardo

University of Buenos Aires

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Philip A. LoBue

Centers for Disease Control and Prevention

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