Isabella Mehling

Number and Locations of Screw Fixation for Volar Fixed-Angle Plating of Distal Radius Fractures: Biomechanical Study

PURPOSE To compare the biomechanical properties of different numbers and locations of screws in a multidirectional volar fixed-angle plate in a distal radius osteotomy cadaver model. METHODS We created an extra-articular fracture in 16 pairs of fresh-frozen human cadaver radiuses. The 32 specimens were randomized into 4 groups. All fractures were fixated with a multidirectional volar fixed-angle plate. We tested 4 different screw-placement options in the distal fragment. The distal fragment was fixed with 4 locking screws in the distal row of the plate in group a, and with 4 locking screws alternately in the distal and proximal rows in group b. In group c, 3 locking screws were used in the proximal row; in group d, 7 locking screws were used, filling all screw holes in the distal and proximal rows of the plate. The proximal fragment was fixed with 3 screws. The specimens were loaded with 80 N under dorsal and volar bending and with 250 N axial loading. Finally, load to failure tests were performed. RESULTS Group d had the highest mean stiffness, 429 N/mm under axial compression, and was statistically significantly stiffer than the other groups. Group b had a mean stiffness of 208 N/mm, followed by group a, with 177 N/mm. Group c showed only a mean stiffness of 83 N/mm under axial compression. There were no statistically significant differences under dorsal and volar bending. CONCLUSIONS In this model of distal radial fractures, there was a difference regarding the stiffness and the placement of screws in the distal rows of a volar fixed-angle plate. Inserting screws in all available holes in the distal fragment offered the highest stability. Using only the proximal row with 3 screws created an unstable situation. Based on these findings, we recommend placing at least 4 screws in the distal fragment and assigning at least 2 screws to the distal row of the multidirectional screw-holes.

Stabilization of fatigue fractures of the dorsal pelvis with a trans-sacral bar. Operative technique and outcome.

INTRODUCTION Due to ageing of our population the number of fatigue fractures of the pelvic ring is steadily growing. These fractures are often treated with bed rest but may result in a disabling immobility with severe pain. An operative treatment is an option in these cases. The aim of operative treatment is bony healing obtained by stable fixation giving back to the patients previous mobility. Optimal surgical treatment is currently under debate. Sacroiliac screw fixation and sacroplasty are used for stabilization of the dorsal pelvis. Due to the technique and the low density of spongious sacral bone, no or only low compression in the fracture site is obtained, which may inhibit bony healing. The trans-sacral bar compression osteosynthesis is presented as an alternative procedure. We present the outcome of 11 patients, who were treated with this method. METHODS The patient is placed in prone position on the operation table. Under image intensifier control, a 5mm threaded sacral bar is inserted through the body of S1 from the left to the right dorsal ilium. Nuts are placed over the bar achieving fracture compression. When anterior pelvic instability is present, an anterior osteosynthesis is also performed. Clinical and radiological outcome were evaluated one year after index surgery with different scoring systems. RESULTS Eleven patients (9 F and 2 M) were treated between 2005 and 2010. The mean age of the patients was 73 years at time of operation. There were no mechanical complications. Postoperatively there was a temporary nerve palsy of L5 in one case. The mean follow-up was 14 months. In all patients, a bony healing of the dorsal pelvic ring was achieved. Seven patients showed a major clinical improvement, in four patients a moderate. CONCLUSIONS Trans-sacral bar osteosynthesis is a promising method for stabilization of fatigue fractures of the pelvic ring. Only with this method, a high interfragmentary compression is achieved, independent of the quality of the spongious bone of the sacral body.

Intramedullary nailing vs. palmar locked plating for unstable dorsally comminuted distal radius fractures: A biomechanical study

BACKGROUND The purpose of this study was to compare the stability of a 2.4mm palmar locking compression plate and a new intramedullary nail-plate-hybrid Targon DR for dorsally comminuted distal radius fractures. METHODS An extraarticular 10mm dorsally open wedge osteotomy was created in 8 pairs of fresh frozen human radii to simulate an AO-A3-fracture. The fractures were stabilized using one of the fixation methods. The specimens were loaded axially with 200 N and dorsal-excentrically with 80 N. 2000cycles of dynamic loading and axial loading-to-failure were performed. FINDINGS Axial loading revealed that intramedullary osteosynthesis (Targon DR: 369 N/mm) was significantly (p=0.017) stiffer than plate osteosynthesis (Locking compression plate: 131 N/mm). With 214 N/mm the intramedullary nail also showed higher stability during dorsal excentric loading than the Locking compression plate with 51 N/mm (p=0.012). After 2000 cycles of axial loading with 80 N the Targon DR-group was significantly stiffer than the Locking compression plate-group under both loading patterns. Neither group showed significant changes in stiffness after 2000 cycles. Under dorsal excentric loading the Targon DR-group was still significantly stiffer with 212 N/mm than the Locking compression plate-group with 45 N/mm (p=0.012). The load to failure tests demonstrated higher stability of intramedullary nailing (625 N) when compared to plate osteosynthesis (403 N) (p<0.025). INTERPRETATION The study shows that intramedullary fixation of a distal AO-A3 radial fracture is biomechanically more stable than volar fixed-angle plating under axial and dorsal-excentric loading in an experimental setup.

Biomechanische Studie zu vier winkelstabilen distalen palmaren Radiusplatten und einer nichtwinkelstabilen Radiusplatte: Steifigkeit und Versagenstests am Kadavermodell / Biomechanical study of four palmar locking plates and one non-locking palmar plate for distal radius fractures: stiffness and load to failure tests in a cadaver model

Zusammenfassung Fünf unterschiedliche Plattensysteme zur Versorgung von distalen Radiusfrakturen über einen palmaren Zugang wurden im biomechanischen Kadavermodell untersucht. Dazu wurde eine 1 cm breite metaphysäre Osteotomie unmittelbar proximal zum Gelenkspalt durchgeführt und die jeweilige Platte entsprechend den Anweisungen des Herstellers fixiert. Unter axialer Belastung wurde das Konstrukt dann in einer pneumatisch angetriebenen Testmaschine (Sincotec) geprüft. Jedes Implantatsystem wurde an jeweils 8 Leichenknochen bezüglich der Steifigkeit gemessen. Keines der Konstrukte zeigte Deformitäten im Osteotomiespalt von über 2 mm unter Lasten bis zu 100 N. Bei Lasten bis zu 250 N stellten sich signifikante Differenzen bezüglich der Steifigkeit und der Versagenscharakteristika der unterschiedlichen Plattensysteme dar. Die mittlere Steifigkeit unter axialer Belastung (MW±SD) betrug 356,4±138,6 N/mm für die Radiuskorrekturplatte ohne lateralen Ausläufer, 299,7±86,3 N/mm für die Radiuskorrekturplatte mit lateralem Ausläufer, 132,8±41,5 N/mm für die distale volare Radiusplatte, 112,5±40,2 N/mm für die 3,5 mm Titan Locking-Compression-Platte und 91,9±29,2 N/mm für die 3,5 mm Standard T-Platte. Dabei zeigte das nichtwinkelstabile Implantat (STP-Platte) die geringste Steifigkeit. Unerwartet gab es Differenzen von über 100% bezüglich der Steifigkeit zwischen den auf den ersten Blick weitgehend ähnlich erscheinenden winkelstabilen Implantaten. Zusätzlich erfolgte die Auswertung der in der Literatur beschriebenen Ergebnisse von biomechanischen Untersuchungen bei der distalen Radiusfraktur. Abstract Five different palmar fixation plate designs were compared in a distal radial osteotomy cadaver model with regard to their biomechanical properties. A metaphyseal osteotomy gap of 1 cm was performed and the osteosynthesis was plated according to the manufacturers instructions. Axial load was applied to the construct by a pneumatic material testing machine. Five implant groups with eight cadavers each were tested concerning stiffness. None of the constructs developed deformity and movement of the fracture gap larger than 2 mm with a load of 100 N. Increasing the load to 250 N revealed significant differences in stiffness and failure load between the different plates. The mean stiffness under axial load (mean±standard deviation) was 356.4± 138.6 N/mm for the radius correction plate without lateral tongue, 299.7±86.3 N/mm for the radius correction plate with lateral tongue, 132.8±41.5 N/mm for the distal volar radius plate, 112.5±40.2 N/mm for the 3.5 mm titanium locking compression plate and 91.9±29.2 N/mm for the standard stainless steel 3.5 mm T-Plate. The non-angular stable implant (STP plate) had the lowest stiffness. Unexpectedly, there were differences over 100% concerning the stiffness between the at first glance nearly similar angular stable implants. Additionally, a review of the literature concerning biomechanical investigations of the distal radial fracture was performed.

Are there any differences in various polyaxial locking systems? A mechanical study of different locking screws in multidirectional angular stable distal radius plates.

Abstract Numerous angular stable plates for the distal radius exist, and technically based comparisons of the polyaxial locking interfaces are lacking. The aim of this mechanical study was to investigate three different locking interfaces of angular stable volar plates by cantilever bending: VA-LCP Two-Column Distal Radius Plates 2.4 mm (Synthes® GmbH, Oberdorf, Switzerland), IXOS® P4 (Martin, Tuttlingen, Germany) and VariAX™ (Stryker®, Duisburg, Germany). We assessed the strength of 0°, 5°, 10° and 15° screw locking angles and tested the bending strength from 10° to 5° angles by cyclic loading until breakage. The final setup repeated the above assessments by inclusion of four locking screws. The single screw-plate interfaces of the VA-LCP showed the highest bending moment at an angle of 0° and 5°, the IXOS® P4 at an angle of 10° and 15° and the VariAX™ when changing the insertion angle from 10° into 5°. The strength of polyaxial locking interfaces and mechanism of failure proved to be different among the examined plates.

Volar fixed-angle plating of distal radius fractures: screws versus pegs--a biomechanical study in a cadaveric model.

Objectives: The purpose of this biomechanical study was to determine whether a multidirectional fixed-angle plate with locking screws or with locking pegs in the distal fragment would optimize fixation of Orthopaedic Trauma Association (OTA) type A3 distal radius fractures. Methods: Eight pairs of fresh–frozen human distal radii were used. Extra-articular distal radius fractures were created and stabilized with a multidirectional volar fixed-angle plate. The radii were randomized into 2 matched-paired groups. The distal fragment in Group I was stabilized with 7 locking screws. The distal fragment in Group II was fixed with 7 locking pegs. The proximal fragment in both groups was fixed with 3 screws. The specimens were tested under torsion and axial compression during static and cyclic tests. Finally, load-to-failure tests were performed under torsion. Results: After 1000 cycles, 99% of the median torsional stiffness remained in the group using screws, whereas only 76% of the median stiffness under torsion remained in the group using pegs (P = 0.018). Under axial compression, median stiffness remained at 93% in the group using screws after 1000 cycles compared with a median of 0% in the group using pegs (P = 0.018). Conclusions: This biomechanical study showed a statistically significant difference between the locking screw and locking smooth peg configuration with regard to stiffness of the constructs after 1000 cycles. The use of locking screws as opposed to smooth locking pegs for OTA type A3 extra-articular distal radius fractures optimizes construct stability.

Locking reconstruction double plating of distal humeral fractures: how many screws in the distal ulnar column segment in A3 fracture provide superior stability? A comparative biomechanical in vitro study.

Objectives: Two 90-degree configurations of locking reconstruction plates with different numbers of screws in the distal ulnar column segment of distal extra-articular humeral fractures with metaphyseal comminution (A3) were biomechanically investigated. Methods: Eight pairs of fresh-frozen human humeri were used. For paired comparison, the humeri were divided into 2 randomized groups. In both groups, double-plate osteosyntheses with locking reconstruction plates were performed in 90-degree configurations. In group 1, the posteriorly placed radial column plate exceeded the capitellum and the ulnar column plate extended into the ulnar sulcus. The ulnar plate was molded around the medial epicondyle and fixed with 3 short angular stable screws distally. In group 2, the posteriorly placed radial column plate was applied analogous to group 1. The locking reconstruction plate placed on the ulnar column was used reaching to the ulnar epicondyle, fixed with 1 long, angular, stable screw in the distal fragment. Stiffness testing for axial load and bending in static and cyclic tests were performed. In static test mode, a load was applied with a frequency of 0.1 Hz. For cyclic loading conditions, a load was applied at 1 Hz for 5000 cycles. Results: All tested specimens adequately resisted simulated physiologic loading conditions with no failure. Comparable stiffness values for axial load (P = 0.161) and significant lower stiffness values for bending (P = 0.017) in group 2 under static bending conditions were found. Considering cyclic loading conditions, no significant alterations in stiffness in each group under axial load occurred. In bending conditions, stiffness values for group 2 were significantly lower than that for group 1 (P = 0.036). Conclusions: Under static and cyclic bending conditions, stiffness in group 2 was significantly lower than that in group 1. Nevertheless, both implant configurations showed no failure of the constructs. Based on these data, when applying locked plates in the clinical setting, more than 1 locked screw applied into the distal ulnar column of the articular segment is recommended.

Mobilization of CD34+-Progenitor Cells in Patients with Severe Trauma

Circulating CD34+ progenitor cells () gained importance in the field of regenerative medicine due to their potential to home in on injury sites and differentiate into cells of both endothelial and osteogenic lineages. In this study, we analyzed the mobilization kinetics and the numbers of CD34+, CD31+, CD45+, and CD133+ cells in twenty polytrauma patients (n = 13 male, n = 7 female, mean age 46.5±17.2 years, mean injury severity score (ISS) 35.8±12.5 points). In addition, the endothelial differentiation capacity of enriched CD34+cells was assessed by analyzing DiI-ac-LDL/lectin uptake, the expression of endothelial markers, and the morphological characteristics of these cells in Matrigel and spheroid cultures. We found that on days 1, 3, and 7 after a major trauma, the number of CD34+cells increased from 6- up to 12-fold (p<0.0001) over the number of CD34+cells from a control population of healthy, age-matched volunteers. The numbers of CD31+ cells were consistently higher on days 1 (1.4-fold, p<0.01) and 7 (1.3-fold, p<0.01), whereas the numbers of CD133+ cell did not change during the time course of investigation. Expression of endothelial marker molecules in CD34+cells was significantly induced in the polytrauma patients. In addition, we show that the CD34+ cell levels in severely injured patients were not correlated with clinical parameters, such as the ISS score, the acute physiology and chronic health evaluation II score (APACHE II), as well as the sequential organ failure assessment score (SOFA-2). Our results clearly indicate that pro-angiogenic cells are systemically mobilized after polytrauma and that their numbers are sufficient for the development of novel therapeutic models in regenerative medicine.

Intraoperative C-arm CT imaging in angular stable plate osteosynthesis of distal radius fractures

The purpose of this study was to analyze the practicability and benefit of intraoperative C-arm computed tomography (CT) imaging in volar plate osteosynthesis of unstable distal radius fractures. During a 1 year period, intraoperative three dimensional (3D) imaging with the ARCADIS Orbic 3D was performed in addition to standard fluoroscopy in 51 cases. The volar angular stable plate oesteosyntheses were analyzed intraoperatively and, if necessary, improved immediately. The duration of the scan and radiation exposure dose were measured. On average, performance of the scan and analysis of the CT dataset took 6.7 minutes. In 31.3% of the surgeries a misplacement of screws was detected and correction was done immediately. C-arm CT imaging can easily be integrated in the normal course of surgery. As a complement to the standard 2D-fluoroscopy, the C-arm CT is a useful tool to evaluate the quality of osteosynthesis.

Biomechanical Comparison of Dorsal Nail Plate Versus Screw and K-Wire Construct for Extra-Articular Distal Radius Fractures in a Cadaver Bone Model

PURPOSE The purpose of the study was to compare the biomechanical stability of distal radius fracture fixation with 2 new implants, the DNP (Hand Innovations LLC, Miami, FL), a dorsal locked hybrid of nail and plate, and the XSCREW (Zimmer, Freiburg, Germany), an implant combining a cannulated screw and K-wires, in a cadaver bone distal radius fracture model. METHODS Eight pairs of fresh-frozen cadaver radii were used. To simulate an extra-articular distal radius fracture, a 5-mm volar open wedge osteotomy was made. Axial loads of 10 to 100 N and torque loads of -1.5 to 1.5 Nm were applied by a testing machine to the intact radii and to the radii after each device was fixed as recommended by the manufacturer. One thousand cycles in torque and failure tests were performed. RESULTS With a median of 136.0 N/mm, the axial stiffness of XSCREW-fixed specimens was higher than that of DNP-fixed specimens, with a median of 69.5 N/mm, but differences were not statistically significant. With a median of 0.163 Nm/ degrees , the torque stiffness of XSCREW-fixed specimens was significantly higher than that of DNP-fixed specimens, with a median of 0.068 Nm/ degrees . The XSCREW-group reached 33% of the axial stiffness and 49% of the torque stiffness of the intact radii, and the DNP-group reached 14% of the axial stiffness and 20% of the torque stiffness of the intact radii. CONCLUSIONS In this human cadaver bone biomechanical study, the XSCREW provided more stability than the DNP in torque stiffness but not in axial stiffness.