Isabelle Loeb

Bisphosphonate-related osteonecrosis of the jaw and its associated risk factors: a Belgian case series.

Bisphosphonate‐related osteonecrosis of the jaw (BROJ) is a serious oral complication of bisphosphonate (BP) treatment involving the exposure of necrotic maxillary or mandibular bone. Our purpose is to describe the clinical presentation of 34 cases of BROJ and to identify potential risk factors.

Régression spontanée d’un lymphome B à grandes cellules du palais

INTRODUCTION Non-Hodgkin lymphomas are common cancers that can develop in the upper aero-digestive tract. We describe a case of a large B-cell palatine lymphoma with spontaneous clinical regression. CASE A 58-year-old female patient presented with a sub-mucosal lesion of the hard palate. CT scan and magnetic resonance imaging revealed a lesion invading the right posterior palatine canal. At the second consultation, 15 days after performing the biopsy, the lesion had disappeared. PET scan proved the absence of lesion. Lymph node biopsy supported the diagnosis of large B-cell lymphoma. DISCUSSION Large B-cell lymphoma of the hard palate is a rare disease. Only 27 cases have been described in the international literature. The anatomopathological analysis is often difficult to perform. The final diagnosis is often made by immunochemistry. The usual treatment is R-CHOP chemotherapy (cyclophosphamide, adriamycin, vincristine, prednisone combined to rituximab) with a 5-year survival rate at 55%.

Lichen plan buccal érosif et onguent de tacrolimus

Immunomodulateur non stéroïdien, le tacrolimus administré par voie systémique est bien connu pour son efficacité dans la prévention et le traitement des rejets de greffes d’organes [1]. Sous forme d’onguent, le tacrolimus est une alternative utile dans la prise en charge des dermatites atopiques [2-3]. Cette substance semble également active dans le traitement d’autres affections de type inflammatoire telles que le lichen plan buccal ou le psoriasis [4]. L’application locale de l’onguent de tacrolimus à faible concentration, de 0,03 % à 0,1 % (Protopic®), dans les lésions de lichen plan buccal érosif donne des résultats très encourageants [5-8].

L'histoplasmose buccale.

Histoplasmosis is an endemic mycosis. Histoplasma capsulatum, and duboisii are the pathogenic agents in humans. The disease is reported as endemic in more than 30 countries. Three clinical forms are distinguished; acute, chronic and disseminated. Oral lesions may take on different clinical aspects which are often associated with disseminated histoplasmosis. Disseminated histoplasmosis is frequently diagnosed in immunocompromised hosts. High risk of mortality dictates rapid diagnosis and treatment.

Fibro-odontome ameloblastique mandibulaire

Le fibro-odontome ameloblastique est une tumeur odontogenique rare et benigne qui affecte generalement les patients jeunes. Nous exposons ici le cas d’une enfant de 10 ans ayant presente un gonflement asymptomatique et lent de la region posterieure de la mandibule. Apres enucleation simple de la tumeur, l’evolution a ete favorable, sans recidive.

Bisphosphonates et osteonecrose maxillomandibulaire

Today, bisphosphonates are very frequently used to relieve patients suffering from various bone diseases, mainly bone metastases and osteoporosis. They have been associated with numerous cases of maxillar and mandibullar osteonecrosis, a severe affection characterized by a high morbidity and for which no consensual treatment has been found yet. After a short update, the authors reviewed indications for bisphosphonates and its pharmacological properties. The pathogenesis, predisposing factors, symptoms, and clinical evaluation of this particular necrosis are described. Preventive and therapeutic managements are suggested.