Isabelle Soutrel
École Normale Supérieure
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Featured researches published by Isabelle Soutrel.
Journal of Hazardous Materials | 2014
I. Saidi; Isabelle Soutrel; Didier Floner; Florence Fourcade; Nizar Bellakhal; Abdeltif Amrane; Florence Geneste
The removal of metronidazole, a biorecalcitrant antibiotic, by coupling an electrochemical reduction with a biological treatment was examined. Electroreduction was performed in a home-made flow cell at -1.2V/SCE on graphite felt. After only one pass through the cell, analysis of the electrolyzed solution showed a total degradation of metronidazole. The biodegradability estimated from the BOD5/COD ratio increased from 0.07 to 0.2, namely below the value usually considered as the limit of biodegradability (0.4). In order to improve these results, indirect electrolysis of metronidazole was performed with a titanium complex known to reduce selectively nitro compounds into amine. The catalytic activity of the titanium complex towards electroreduction of metronidazole was shown by cyclic voltammetry analyses. Indirect electrolysis led to an improvement of the biodegradability from 0.07 to 0.42. To confirm the interest of indirect electroreduction to improve the electrochemical pretreatment, biological treatment was then carried out on activated sludge after direct and indirect electrolyses; different parameters were followed during the culture such as pH, TOC and metronidazole concentration. Both electrochemical processes led to a more efficient biodegradation of metronidazole compared with the single biological treatment, leading to an overall mineralization yield for the coupling process of 85%.
Environmental Technology | 2013
Nicolas Cimetiere; Isabelle Soutrel; Marguerite Lemasle; Alain Laplanche; André Crocq
The study of the occurrence and fate of pharmaceutical compounds in drinking or waste water processes has become very popular in recent years. Liquid chromatography with tandem mass spectrometry is a powerful analytical tool often used to determine pharmaceutical residues at trace level in water. However, many steps may disrupt the analytical procedure and bias the results. A list of 27 environmentally relevant molecules, including various therapeutic classes and (cardiovascular, veterinary and human antibiotics, neuroleptics, non-steroidal anti-inflammatory drugs, hormones and other miscellaneous pharmaceutical compounds), was selected. In this work, a method was developed using ultra performance liquid chromatography coupled to tandem mass spectrometry (UPLC–MS/MS) and solid-phase extraction to determine the concentration of the 27 targeted pharmaceutical compounds at the nanogram per litre level. The matrix effect was evaluated from water sampled at different treatment stages. Conventional methods with external calibration and internal standard correction were compared with the standard addition method (SAM). An accurate determination of pharmaceutical compounds in drinking water was obtained by the SAM associated with UPLC–MS/MS. The developed method was used to evaluate the occurrence and fate of pharmaceutical compounds in some drinking water treatment plants in the west of France.
Australian Journal of Chemistry | 2015
Maha Dendeni; Nicolas Cimetiere; Isabelle Soutrel; Jean Paul Guégan; Najib Ben Hamida; Abdeltif Amrane
Quinapril and quinaprilat are two angiotensin-converting enzyme inhibitors (ACEIs) characterized by a peak broadening and splitting when they were analyzed by ultra-performance liquid chromatography (UPLC). This phenomenon is due to the existence of the two isomers cis and trans around the amide band. In order to confirm the existence of the two conformers and allow identification of the predominant form, NMR studies of quinapril, involving 1H, 13C, 1H-1HCOSY, Impact-HMBC, JMOD, HSQC, and ROESY have been conducted in this work. The analyses allowed us to identify the predominant form of quinapril; the conformer trans is the predominant form (75 %). In addition, this study highlights the important benefits of UPLC to separate quinapril and quinaprilat isomers due to its high resolving power. The effect of various operating conditions on the retention peak, namely, splitting and band broadening of quinaprilat and quinapril, has been qualitatively examined in this study. Several practical experimental conditions have been tested, allowing both the elution of the two ACEIs as single peaks, while keeping at the same time an acceptable separation. The effect of various factors on the conformational s-cis–s-trans equilibrium of quinapril and quinaprilat, namely, the composition of the mobile phase, column temperature, flow rate, pH, and type and amount of organic modifier was investigated by UPLC–DAD (diode array detector) with a BEH C18 column (100 mm, 2.1 mm internal diameter × 1.7 µm particle diameter). Several deconvolution models were used to model overlapped peaks and to determine resolution. Results obtained showed that a mobile phase consisting of ammonium buffer (10 mM; pH 8) and acetonitrile allows the separation of the quinapril and quinaprilat conformers. Maximum resolution was obtained for a composition of mobile phase (55/45) and (65/35) (ammonium buffer/acetonitrile, v/v) for quinapril and quinaprilat, respectively at 45°C and flow rates of 0.4 and 0.5 mL min–1.
Applied Catalysis B-environmental | 2016
Samia Ben Hammouda; Florence Fourcade; Aymen Amine Assadi; Isabelle Soutrel; Nafaa Adhoum; Abdeltif Amrane; Lotfi Monser
Journal of The Taiwan Institute of Chemical Engineers | 2015
Dorsaf Mansour; Florence Fourcade; Isabelle Soutrel; Didier Hauchard; Nizar Bellakhal; Abdeltif Amrane
European Journal of Organic Chemistry | 2005
Myriam Roussel; Thierry Benvegnu; Vincent Lognoné; Hervé Le Deit; Isabelle Soutrel; Isabelle Laurent; Daniel Plusquellec
Journal of Electroanalytical Chemistry | 2013
I. Saidi; Isabelle Soutrel; Florence Fourcade; Abdelatif Amrane; Didier Floner; Nizar Bellakhal; Florence Geneste
Electrochimica Acta | 2016
I. Saidi; Isabelle Soutrel; Florence Fourcade; Abdeltif Amrane; Nizar Bellakhal; Florence Geneste
Chemical Engineering Journal | 2016
Pierre-François Biard; Baraa Werghi; Isabelle Soutrel; Romain Orhand; Annabelle Couvert; Audrey Denicourt-Nowicki; Alain Roucoux
Arabian Journal of Chemistry | 2015
Yassine Kadmi; Lidia Favier; Tania Yehya; Isabelle Soutrel; Andrei Ionuţ Simion; Christophe Vial; Dominique Wolbert