Isao Kawakita

Leukocyte adherence inhibition microtest for the detection of cell-mediated immunity to tumor in gastric cancer patients.

The reactivities of leukocytes from gastric cancer and noncancer patients to gastric tumor and normal tissue extracts were tested by the leukocyte adherence inhibition (LAI) microtest, assessing cell-mediated immunoreactivity to adenocarcinoma of the stomach. The reactivities were expressed with the LAI index. All leukocyte preparations showed low reactivities, a LAI index of less than 20%, to normal tissue extracts and only the preparations of leukocytes from cancer patients displayed high reactivities, a LAI index of more than 20%, to tumor extracts. Assuming that a patient is sensitized to gastric tumor antigen if his leukocytes respond to at least one tumor extract with a LAI index of more than 20%, approximately half of the cancer tumor antigen. Thus, the LAI microtest appears to be a simple, rapid and specific method for demonstrating cell-mediated immunity to tumor.

CLINICAL EFFICIENCY IN COLOSTOMY EXAMINATION USING A NEWLY DEVISED BARIUM ENEMA APPLIANCE

人工肛門より明瞭な注腸造影を得るために, 内外2筒からなる陰圧型の人工肛門注腸補助器を開発した.これとgyroscopeとの併用により, 直腸癌術後などの人工肛門保有者30例に注腸X線検査を行い, つぎのような利点が判明した.すなわち (1) 残存結腸の完全な二重造影像が得られ,(2) 人工肛門周囲を汚すことなく検査が終了し,(3) 腸管穿孔の心配が全くないことなどである.これらの検査でわれわれの補助器が有用であった症例を紹介し, さらに人工肛門からの高圧浣腸にも応用しているのでその実際について説明した.

A new device for barium-enema examination following colostomy.

The authors developed a colostomy appliance for use during barium-enema examinations. It is 8 cm in diameter and 4 cm in height, and is made of acrylic resins. With the use of this device, 21 patients were fluoroscopically examined through the stoma; good contrast views of the lower intestinal tract were obtained in all cases without leakage of barium or air.