Isao Tatekawa
Kyorin University
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Publication
Featured researches published by Isao Tatekawa.
Journal of Drug Targeting | 1996
Kazuo Akima; Hisashi Ito; Yuhei Iwata; Kayoko Matsuo; Nobutoshi Watari; Mitsuo Yanagi; Hiroo Hagi; Kazumi Oshima; Akikuni Yagita; Yutaka Atomi; Isao Tatekawa
To enhance the selective delivery of antitumor drugs into regional lymph nodes and cancerous tissues via a hyaluronate (HA) receptor (CD44), we synthesized HA-mitomycin C complex and HA-epirubicin complex. To investigate the specific distribution of HA into regional lymph nodes and to evaluate the HA receptor on lewis lung carcinoma cells, we also synthesized 14C-labelled HA and fluorescent HA (FR-HA). The metabolic studies of 14C-HA and HA-epirubicin complex were performed in rats. The specific distribution of both compounds to the lymph nodes were observed after sc treatment. Internalization mechanisms of HA into carcinoma cells (lewis lung carcinoma) via HA receptor was investigated using fluorescent HA (FR-HA) in vitro. Internalization of FR-HA following binding to the cell surfaces was observed. HA-Mitomycin C (MMC) exhibited potent anti-metastatic effects against lewis lung carcinoma implanted in mice at an extremely low dose (0.01 mg/kg) whereas free MMC had no effects.
Gastroenterologia Japonica | 1988
Hidenori Nakama; Hiroshi Saito; Ryosuke Kakizaki; Toshitaka Takeshita; Pei-Chin Chen; Masahiro Asaka; Masao Saitoh; Tokiaki Toyohara; Taihei Murakami; Masahide Fujita; Taguchi T; Masahiro Tada; Nozomi Yamaguchi; N. Yoshikawa; Makoto Hoshino; Tatsuyuki Satoh; Tadashi Kodama; Kenji Yamao; Yasuo Naito; Tadasu Fuji; Tsuyoshi Aibe; Yoshiyuki Wada; Wataru Kimura; Kanenari Uchiyama; Isao Tatekawa; Toshimichi Nakayama; Tadashi Yoshida; Takukazu Nagakawa; Tadashi Miyashita; Kotaro Uchida
S OF SELECTED PAPERS PRESENTED AT THE 73RD GENERAL MEETING OF THE JAPANESE SOCIETY OF GASTROENTEROLOGY Tokyo, Japan, April 7-9, 1987 Chairman : Shinroku ASHIZAWA, M. D.
Japanese Journal of Cancer Research | 1996
Hisashi Ito; Akikuni Yagita; Mitsuharu Fujitsuka; Yutaka Atomi; Isao Tatekawa
Jpn J Gastroenterol Surg | 1982
Masaki Kitajima; Fumitaka Kaga; Yoshitake Ikeda; Hiroki Kenmizaki; Mitsuhisa Ueda; Akikuni Yagita; Mikiko Ono; Isao Tatekawa; Satoru Sohma; Naoyoshi Fukuzumi
Acta Gastro-Enterologica Belgica | 1974
Satoru Sohma; Isao Tatekawa; Y Okamoto; T Matsuda; M Ono; T Aoyagi; R Fujita
Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1993
Isao Tatekawa; 浜野 恭一
Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1991
Hisaki Fukushima; Minoru Matsuda; Noboru Suzuki; Tateo Hanaoka; Kin-ichi Nabeya; Masaki Kitajima; Isao Tatekawa
Nippon Daicho Komonbyo Gakkai Zasshi | 1990
K. Fukushima; Akikuni Yagita; I. Orima; Isao Tatekawa; T. Kumakawa; M. Mori
Journal of the Kyorin Medical Society | 1990
Naoki Komori; Yoshikazu Yamaguchi; Hideaki Mori; Toshio Muraki; Atsushi Manabe; Masami Nakano; Masataka Ito; Takashi Abe; Shin'ichi Takahashi; Shozo Saito; Toshio Aoyagi; Hiroki Kenmizaki; Yasuaki Han; Kenichi Fukushima; Masaki Kitajima; Isao Tatekawa; Naoyoshi Fukuzumi
Nippon Daicho Komonbyo Gakkai Zasshi | 1989
K. Fukushima; Akikuni Yagita; H Matsumoto; Hisashi Ito; Isao Tatekawa
