Isham Kimbell

Comparison of acetophenazine with perphenazine in schizophrenics: Demonstration of differential effects based on computer‐derived diagnostic models

Acetophenazine was compared with a closely related phenothiazine tranquilizer, perphenazine, under controlled conditions in 98 schizophrenic men newly admitted to five Veterans Administration hospitals. Clinical response was evaluated by two separate rating scales, the Inpatient Multidimensional Psychiatric Scale (IMPS) and the Brief Psychiatric Rating Scale (BPRS).

Specific therapeutic actions of acetophenazine, perphenazine, and benzquinamide in newly admitted schizophrenic patients

One hundred newly admitted schizophrenic men were treated with either acetophenazine, perphenazine, or benzquinamide in a controlled study. Each drug produced substantial and essentially equal improvement according to most criteria examined. Classification of patients according to standard nomenclature‐derived prototypes, as paranoid and nonparanoid, revealed no significant differences between drugs, all being somewhat more effective in paranoid patients. Regression analysis revealed a similar trend. The different response to antipsychotic drugs of paranoid as compared with nonparanoid schizophrenic patients provides still further evidence for a difference between these two schizophrenic clinical subtypes.