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Issei Nitta

Mitsubishi

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Publication

Featured researches published by Issei Nitta.

Nucleosides, Nucleotides & Nucleic Acids | 1992

Synthesis of some analogues of 1-[(2-hydroxyethoxy)-methyl]-6-(phenylthio)thymine (hept) which have different types of acyclic structures

Hiromichi Tanaka; Tadashi Miyasaka; K Sekiya; Hideaki Takashima; Masaru Ubasawa; Issei Nitta; Masanori Baba; Richard T. Walker; E. De Clercq

Analogues of a recently developed specific anti-HIV-1 agent HEPT, 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine, having different types of acyclic moieties were synthesized based on lithiation chemistry. Anti-HIV-1 activity of these analogues is also described.

Nucleosides, Nucleotides & Nucleic Acids | 1991

Lithiation of Uracilnucleosides and its Application to the Synthesis of a New Class of Anti-HIV-1 Acyclonucleosides

Hiromichi Tanaka; Masanori Baba; Hiroyuki Hayakawa; Kazuhiro Haraguchi; Tadashi Miyasaka; Masaru Ubasawa; Hideaki Takashima; K Sekiya; Issei Nitta; Richard T. Walker; Erik De Clercq

Abstract A highly general and regioselective modification of the base moiety of uracilnucleosides can be accomplished based on lithiation chemistry. An application of this approach to the synthesis of various acyclouridine derivatives, in which both C-5 and C-6 positions were substituted, was carried out to improve the HIV-1 specific inhibitory activity of a new lead compound, l-[(2-hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT).

Journal of Medicinal Chemistry | 1992

Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues : effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity

Hiromichi Tanaka; Hideaki Takashima; Masaru Ubasawa; Kouichi Sekiya; Issei Nitta; Masanori Baba; Shiro Shigeta; Richard T. Walker; Erik De Clercq; Tadashi Miyasaka

Journal of Medicinal Chemistry | 1991

Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17.alpha.-esters containing a functional group

Hiroaki Ueno; Akira Maruyama; Motoyoshi Miyake; Etsuko Nakao; Kenichiro Nakao; Kohei Umezu; Issei Nitta

Bulletin of the Chemical Society of Japan | 1985

The syntheses of the corticoid side chain. I: An improved method for the preparation of 17α-hydroxyprogesterone from androst-4-ene-3,17-dione

Issei Nitta; Shinichiro Fujimori; Hiroaki Ueno

Archive | 1988

9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient

Shuji Morita; Ken-Ichi Saito; Kunihiro Ninomiya; Akihiro Tobe; Issei Nitta; Mamoru Sugano

Archive | 1984

Thieno[2,3-d]pyrimidine derivatives and salts thereof

Kunihiro Ninomiya; Issei Nitta; Akihiro Tobe; Mitsuo Egawa; Ryoji Kikumoto

Archive | 1985

Piperazine derivatives and their acid addition salts

Harukazu Fukami; Shinya Inoue; Issei Nitta; Kenichiro Nakao; Ryoji Kikumoto

Bulletin of the Chemical Society of Japan | 1985

The Syntheses of the Corticoid Side Chain. III. A New Synthesis of 17α,21-Dihydroxypregna-1,4-diene-3,20-dione 17,21-Diacetate from Androsta-1,4-diene-3,17-dione

Issei Nitta; Shinichiro Fujimori; Toshio Haruyama; Shinya Inoue; Hiroaki Ueno

Archive | 1988

4-Aminopyridine derivatives and their acid addition salts

Kunihiro Ninomiya; Ken-Ichi Saito; Shuji Morita; Akihiro B Mitsubishi Tobe; Issei Nitta

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Akihiro Tobe

Mitsubishi

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Kunihiro Ninomiya

Mitsubishi

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Ryoji Kikumoto

Mitsubishi

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Shinya Inoue

Mitsubishi

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Kenichiro Nakao

Mitsubishi

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Shinichiro Fujimori

Mitsubishi

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Shuji Morita

Mitsubishi Chemical Corporation

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Hiroaki Ueno

Mitsubishi

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Mamoru Sugano

Mitsubishi

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Harukazu Fukami

Mitsubishi

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