Itsuo Uchida

Yasuki Yamada; Koji Ando; Kazuya Komiyama; Saizo Shibata; Ikuro Nakamura; Yoshiharu Hayashi; Kiyoteru Ikegami; Itsuo Uchida

A series of low molecular renin inhibitors (molecular weight ∗< 600) were prepared and their biological activities were evaluated. The inhibitors containing indole-2-carbonyl moieties at the P3 position and 2-amino-3,5-anti-diol fragment at the P1-P1′ position showed renin inhibitory activities with IC50 of 10−8 M order and good blood pressure lowering effects after oral administration to sodium-depleted marmosets.

Yasuki Yamada; Eiji Shirakawa; Koji Ando; Saizo Shibata; Itsuo Uchida

Abstract The aldol reaction of optically active α-alkoxycarbonylamino aldehydes with a silyl enol ether in the presence of a Lewis acid afforded γ-amino-β-hydroxyketones diastereoselectively. The effect of the α-amide proton on the diastereoselectivity is discussed.

Hisashi Shinkai; Takao Ito; Tetsuya Iida; Yuki Kitao; Hideki Yamada; Itsuo Uchida

Hisashi Shinkai; Syoji Onogi; Masahiro Tanaka; Tsutomu Shibata; Megumi Iwao; Korekiyo Wakitani; Itsuo Uchida

Hisashi Shinkai; Kimiya Maeda; Takahiro Yamasaki; Hiroshi Okamoto; Itsuo Uchida

Hidetsura Cho; Susumu Katoh; Shinsuke Sayama; Kengo Murakami; Hiroyuki Nakanishi; Yasuyuki Kajimoto; Hiroshi Ueno; Hisashi Kawasaki; Kazuo Aisaka; Itsuo Uchida

Hidetsura Cho; Kengo Murakami; Hiroyuki Nakanishi; Akitaka Fujisawa; Hirotaka Isoshima; Misako Niwa; Kazuhide Hayakawa; Yasunori Hase; Itsuo Uchida; Hidenori Watanabe; Korekiyo Wakitani; Kazuo Aisaka

Takashi Inaba; Angela G. Birchler; Yasuki Yamada; Shoichi Sagawa; Katsuyuki Yokota; and Koji Ando; Itsuo Uchida

Hiroshi Ueno; Katsuyuki Yokota; Jun-ichi Hoshi; Katsutaka Yasue; Mikio Hayashi; Yasunori Hase; Itsuo Uchida; Kazuo Aisaka; Susumu Katoh; Hidetsura Cho

Hidetsura Cho; Shinsuke Sayama; Susumu Katoh; Kazuo Aisaka; Itsuo Uchida