Iva Topić
University of Zagreb
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Publication
Featured researches published by Iva Topić.
Leukemia Research | 2013
Iva Topić; Marina Ikić; Sanja Ivčević; Nataša Kovačić; Ana Marušić; Rajko Kusec; Danka Grčević
We investigated the role of bone morphogenetic proteins (BMPs) in suppression of all-trans retinoic acid (ATRA)-mediated differentiation of leukemic promyelocytes. In NB4 and HL60 cell lines, BMPs reduced the percentage of differentiated cells, and suppressed PU.1 and C/EBPε gene expression induced by ATRA. BMP and ATRA synergized in the induction of ID genes, causing suppression of differentiation. In primary acute promyelocytic leukemia bone-marrow samples, positive correlation of PML/RARα and negative of RARα with the expression of BMP-4, BMP-6 and ID genes were found. We concluded that BMPs may have oncogenic properties and mediate ATRA resistance by a mechanism that involves ID genes.
World Journal of Surgical Oncology | 2011
Damir Tomac; Darko Chudy; Smiljka Lambaša; Iva Topić; Gordan Grahovac; Arijana Zoric
BackgroundGlioblastoma multiforme is a highly malignant primary brain tumor that shows marked local aggressiveness, but extracranial spread is not a common occurrence. We present an unusual case of recurrent glioblastoma in 54-year old male that spread through the scull base to the ethmoid and sphenoid sinuses, to the orbita, pterygomaxillar fossa, and to the neck.MethodsA 54-year old male underwent left temporal resection because of brain tumor of his left temporal lobe. Operation was followed by external beam radiation combined with temozolomide. The tumor recurred eight months after first surgery. The patient developed swelling of left temporal region, difficult swallowing and headache. MRI of head showed recurrent tumor, which invaded orbita, ethmoid and sphenoid sinuses, nasal cavity, pterygomaxillar fossa.ResultsThe patient died ten months after initial diagnosis of glioblastoma multiforme, and two months after his second operation.ConclusionsThe aggressive surgical operation helped to downsize the tumor mass as much as possible, but did not prolonged significantly the life or improved the life quality of the patient. The current literature is reviewed, and the diagnostic approaches as well as therapeutic options are discussed.
American Journal of Forensic Medicine and Pathology | 2008
Vedrana Petrovečki; Daniela Salopek; Iva Topić; Ana Marušić
The uniqueness of anatomic structures and their variations provide the basis for forensic identification. During the identification process of 1991-1995 Croatian war victims, forensic pathologists and forensic anthropologists were faced with the problem of incomplete skeletal remains and insufficient premortem medical data. Here we present a case of anterior shoulder dislocation, which was a key confirmation in the identification of a war victim. In our case, anterior shoulder dislocation was not medically treated for 15 years, and the changes in the glenoid cavity and coracoid process indicated morphologic adaptation of anatomic structures to the new mechanical and physiological demands.
Annals of Anatomy-anatomischer Anzeiger | 2007
Daniela Salopek; Ana Dujmovic; Julijana Hadjina; Iva Topić
American Journal of Obstetrics and Gynecology | 2011
Gordan Grahovac; Milorad Vilendecic; Mirjana Vukelić-Marković; Iva Topić; Smiljka Lambaša
Dialysis & Transplantation | 2006
Iva Topić; Tihana Brkljacic; Gordan Grahovac
International Conference on Bone Morphogenetic Proteins (6 ; 2006) | 2006
Iva Topić; Sanja Ivčević; Rajko Kušec; Maruška Marušić Vrsalović; Daniela Salopek; Ana Marušić; Danka Grčević
6th International Conference on Bone Morphogenetic Proteins : Abstract Book | 2006
Danka Grčević; Iva Topić; Nataša Kovačić; Zrinka Jajić; Sanja Ivčević; Fran Grubišić; Vedran Katavić; Ana Marušić
5th International Congress of Spondyloathropaties | 2006
Zrinka Jajić; Nataša Kovačić; Fran Grubišić; Iva Topić; Danka Grčević; Ana Marušić
The Fourth European-American School in Forensic Genetics and Mayo Clinic Course in Advanced Molecular and Cellular Medicine | 2005
Daniela Salopek; Iva Topić; Vedran Katavić; Ana Marušić