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Featured researches published by Iva Topić.


Leukemia Research | 2013

Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells

Iva Topić; Marina Ikić; Sanja Ivčević; Nataša Kovačić; Ana Marušić; Rajko Kusec; Danka Grčević

We investigated the role of bone morphogenetic proteins (BMPs) in suppression of all-trans retinoic acid (ATRA)-mediated differentiation of leukemic promyelocytes. In NB4 and HL60 cell lines, BMPs reduced the percentage of differentiated cells, and suppressed PU.1 and C/EBPε gene expression induced by ATRA. BMP and ATRA synergized in the induction of ID genes, causing suppression of differentiation. In primary acute promyelocytic leukemia bone-marrow samples, positive correlation of PML/RARα and negative of RARα with the expression of BMP-4, BMP-6 and ID genes were found. We concluded that BMPs may have oncogenic properties and mediate ATRA resistance by a mechanism that involves ID genes.


World Journal of Surgical Oncology | 2011

Extracranial propagation of glioblastoma with extension to pterygomaxillar fossa

Damir Tomac; Darko Chudy; Smiljka Lambaša; Iva Topić; Gordan Grahovac; Arijana Zoric

BackgroundGlioblastoma multiforme is a highly malignant primary brain tumor that shows marked local aggressiveness, but extracranial spread is not a common occurrence. We present an unusual case of recurrent glioblastoma in 54-year old male that spread through the scull base to the ethmoid and sphenoid sinuses, to the orbita, pterygomaxillar fossa, and to the neck.MethodsA 54-year old male underwent left temporal resection because of brain tumor of his left temporal lobe. Operation was followed by external beam radiation combined with temozolomide. The tumor recurred eight months after first surgery. The patient developed swelling of left temporal region, difficult swallowing and headache. MRI of head showed recurrent tumor, which invaded orbita, ethmoid and sphenoid sinuses, nasal cavity, pterygomaxillar fossa.ResultsThe patient died ten months after initial diagnosis of glioblastoma multiforme, and two months after his second operation.ConclusionsThe aggressive surgical operation helped to downsize the tumor mass as much as possible, but did not prolonged significantly the life or improved the life quality of the patient. The current literature is reviewed, and the diagnostic approaches as well as therapeutic options are discussed.


American Journal of Forensic Medicine and Pathology | 2008

Chronic unreduced anterior shoulder dislocation: application of anatomy to forensic identification.

Vedrana Petrovečki; Daniela Salopek; Iva Topić; Ana Marušić

The uniqueness of anatomic structures and their variations provide the basis for forensic identification. During the identification process of 1991-1995 Croatian war victims, forensic pathologists and forensic anthropologists were faced with the problem of incomplete skeletal remains and insufficient premortem medical data. Here we present a case of anterior shoulder dislocation, which was a key confirmation in the identification of a war victim. In our case, anterior shoulder dislocation was not medically treated for 15 years, and the changes in the glenoid cavity and coracoid process indicated morphologic adaptation of anatomic structures to the new mechanical and physiological demands.


Annals of Anatomy-anatomischer Anzeiger | 2007

Bilateral arterial and nervous variations in the human upper limb: a case report.

Daniela Salopek; Ana Dujmovic; Julijana Hadjina; Iva Topić


American Journal of Obstetrics and Gynecology | 2011

An unexpected obstacle

Gordan Grahovac; Milorad Vilendecic; Mirjana Vukelić-Marković; Iva Topić; Smiljka Lambaša


Dialysis & Transplantation | 2006

Survey of medical students about attitudes toward organ donation

Iva Topić; Tihana Brkljacic; Gordan Grahovac


International Conference on Bone Morphogenetic Proteins (6 ; 2006) | 2006

BMP-2, BMP-4, AND BMP-6 Inhibit the Differentiation of Leukemic NB-4 Cell Line Induced by All-trans-retinoic Acid Treatmet

Iva Topić; Sanja Ivčević; Rajko Kušec; Maruška Marušić Vrsalović; Daniela Salopek; Ana Marušić; Danka Grčević


6th International Conference on Bone Morphogenetic Proteins : Abstract Book | 2006

Patients with rheumatoid arthritis have higher expression of BMP-6 in the peripheral blood mononuclear cells compared with patients with spondyloarthritis

Danka Grčević; Iva Topić; Nataša Kovačić; Zrinka Jajić; Sanja Ivčević; Fran Grubišić; Vedran Katavić; Ana Marušić


5th International Congress of Spondyloathropaties | 2006

Decresed expression of bone morphogenetic proteins 2 and 6 in the peripheral blood mononuclear cells of patients with spondyloarhritis

Zrinka Jajić; Nataša Kovačić; Fran Grubišić; Iva Topić; Danka Grčević; Ana Marušić


The Fourth European-American School in Forensic Genetics and Mayo Clinic Course in Advanced Molecular and Cellular Medicine | 2005

Bone phenotype of IL-7 transgenic mice

Daniela Salopek; Iva Topić; Vedran Katavić; Ana Marušić

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Gordan Grahovac

Clinical Hospital Dubrava

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