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Publication
Featured researches published by Ivan Čundrle.
Journal of Neurology | 2005
Josef Bednarik; Petr Vondráček; Ladislav Dušek; Eva Moravcová; Ivan Čundrle
AbstractAlthough numerous clinical, laboratory, and pharmacological variables have been reported as significant risk factors for critical illness polyneuromyopathy (CIPM), there is still no consensus on the aetiology of this condition.Objectives of the study were to assess the clinical and electrophysiological incidence and risk factors for CIPM.A cohort of critically ill patients was observed prospectively for a one–month period and the association between neuromuscular involvement and various potential risk factors was evaluated. Sixty one critically ill patients completed the follow–up (30 women, 31 men, median age 59 years).CIPM development was detected clinically in 17 patients (27.9 %) and electrophysiologically in 35 patients (57.4 %). CIPM was significantly associated with the presence and duration of systemic inflammatory response syndrome and the severity of multiple, respiratory, central nervous, and cardiovascular organ failures. The median duration of mechanical ventilation was significantly longer in patients with CIPM than in those without (16 vs 3 days, p < 0.001). Independent predictors of CIPM obtainable within the 1st week of critical illness were the admission sequential organ failure assessment score (odds ratio [OR], 1.15; 95% confidence interval [CI], 1.02–1.36), the 1st week total sequential organ failure assessment scores (OR, 1.14; 95 % CI, 1.06–1.46) and the 1st week duration of systemic inflammatory response syndrome (OR, 1.05; 95% CI, 1.01–1.15). They were able to correctly predict the development of CIPM at the end of the 1st week in about 80% of critically ill cases.In conclusion, the presence and duration of systemic inflammatory response syndrome and the severity of multiple and several organ failures are associated with increased risk of the development of CIPM.
Clinical Neurology and Neurosurgery | 2002
Roman Gál; Ivan Čundrle; Iveta Zimová; Martin Smrčka
The authors present a group of patients with severe head injuries in which deliberate mild hypothermia was carried out together with the standard treatment protocol according to the European Brain Injury Consortium. Thirty patients with severe head injuries with Glasgow Coma Scale (GCS) score of 3-8 were enrolled into the study. The subjects were divided into two groups. The average age in the hypothermic group of 15 patients was 35 years. The average GCS was 4.5 at the site of accident. Eight patients (53%) sustained associated severe injuries of other organs. The average age of the 15 patients in the normothermic control group was 39 years with an average GCS of 4.3. All the patients in the normothermic group and 11 patients in the hypothermic group underwent neurosurgery, five of them also decompressive craniotomy. Artificial ventilation with continuous monitoring of intracranial pressure (ICP), cerebral perfusion pressure (CPP), arterial blood pressure, jugular bulb oximetry and urinary bladder temperature were instituted in the ICU. Cooling to a core temperature of 34 degrees C in the hypothermic group was achieved by forced air cooling in combination with circulating-water mattress cooling (Blanketrol II, Cincinnati Sub-Zero) and maintained for 72 h. The difference in the Glasgow Outcome Scale (GOS) between the hypothermic and normothermic groups of patients after 6 months was not statistically significant (P value 0.0843). In the hypothermic group, however, good neurological outcome (GOS 4 and 5) was reached in 13 patients (87%), which represents a 40% increase compared with the normothermic control group in which good neurological outcome was reached in 7 patients (47%). Mean normothermia ICP value of 18+/-2 mmHg was significantly (P value 0.0007) reduced during mild hypothermia therapy to 12+/-2 mmHg. Mean normothermia CPP value of 72+/-3 mmHg significantly increased (P value 0.0007) during this time to 80+/-4 mmHg with unchanged systolic arterial pressure (P value 0.9013). There were no cardiac or coagulopathy-related complications. Our results showed that mild therapeutic hypothermia could be useful in improving the outcome and neurological recovery in patients with severe head injuries.
Bratislavské lekárske listy | 2009
Roman Gál; Martin Slezák; Iveta Zimová; Ivan Čundrle; Helena Ondrášková; Dagmar Seidlová
Bratislavské lekárske listy | 2003
Roman Gál; Ivan Čundrle; Seidlova J; Zdeněk Kala; Prochazka
Archive | 1999
Pavel Ševčík; Ivan Čundrle
Anaesthesist | 1990
Dastych M; Ivan Čundrle; Otto Vlach
Archive | 2012
Ivan Čundrle; Helena Ondrášková; Hana Horálková
Archive | 2012
Ivan Čundrle; Martina Mokrá; Hana Horálková; Helena Ondrášková; R. Čumlivski
Archive | 2011
Ivan Čundrle; Helena Ondrášková; Petra Minarčíková; Iveta Zimová; Roman Gál; Hana Horálková; Martina Mokrá
Archive | 2010
Ivan Čundrle