Ivan D. Baronofsky

Right atrial myxoma. Diagnosis during life: successful surgical removal.

Abstract A case of right atrial myxoma is reported which was diagnosed clinically, proved by angiocardiography, and successfully removed by open heart surgery. The clinical manifestations of benign left and right atrial tumors are reviewed.

Obstruction of Splenic Vein Increases Weight of Stomach and Predisposes to Erosion or Ulcer.

Conclusions 1. Partial obstruction to the venous outflow from the stomach increases its weight in rabbits and dogs. 2. Esophageal varices can be produced by portal or splenic vien obstruction and, when histamine-inbeeswax is given to such animals, esophageal and gastric erosions and bleeding are produced. 3. Portal or splenic vien obstruction abets the ulcer diathesis.

Cardiac Function in Experimental Mitral Stenosis

The results of 85 combined right and left heart catheterizations in normal dogs and dogs with experimental mitral stenosis are presented. Animals lived as long as 10 months with elevated pulmonary vein pressures. Pulmonary vein pressures in excess of 15 mm. Hg were associated with mitral orifice areas which were smaller than those found in normal animals. Elevation of pulmonary vein pressure was associated with a decrease in the pulmonary vascular pressure gradient, with no change in cardiac index as measured and with a decrease in calculated pulmonary vascular resistance.

Pulmonary valvular stenosis with intact ventricular septum: Results of the brock type valvulotomy

Abstract 1.1. In a group of twenty patients studied before and after the Brock valvulotomy, the average preoperative right ventricular systolic pressure was 116 mm. Hg, the average postoperative value 56 mm. Hg. Excluding five cases in which no significant change occurred, the average preoperative value was 123 and the postoperative value 43 mm. Hg. The five failures might be ascribed to the presence of undetected infundibular pulmonary stenosis or to the possibility that the valvulotome slipped through a fibrous valve without making an incision. 2.2. In a group of seven patients with right to left shunt at the atrial level, the average preoperative right ventricular systolic pressure was 143 mm. Hg and the postoperative 45 mm. Hg. In addition the hemoglobin dropped from 20.0 to 15.3 gm. per cent and the arterial oxygen saturation rose from 75 to 89 per cent. 3.3. Vigorous dilatation of the valve following incision with the valvulotome is deemed to be an important determinant of a successful operative procedure.

Fate of Intravenously Injected Fat Its Role in the Production of Ulcer

Conclusios Fat emboli may cause gastric and/or duodenal erosions or ulcers. The presence of fat emboli after intravenous injection of fat may be demonstrated in the lung, brain, kidney and stomach. Its rate of disappearance in experimental animals is such that after 4 days it is found in sections of lung tissue in 41%, brain 11.1%, kidney 34.4% and the stomach of 3.7% of the sections examined. On the contrary, in sections of those animals sacrificed within one to four days after the intravenous injection of fat, the incidence of demonstrable fat emboli in the same tissues was: lung 91%, brain 61%, kidney 73.9% and stomach 47.8%.

An Evaluation of Wedge Pressures in Dogs under Conditions of Normal and Elevated Pulmonary Vascular Pressures

Fifty-six combined right and left heart catheterizations in normal dogs and dogs with experimental mitral stenosis failed to show a significant positive correlation between pulmonary artery wedge pressure and pulmonary vein pressure when the latter was below approximately 17 mm. Hg. Evidence is presented which suggests that the wedged catheter outlets are totally occluded in many instances in the dog. Pulmonary vein wedge pressure reflected a pressure nearer the pulmonary artery pressure than the expected capillary pressure. One instance of mitral regurgitation revealed large pulmonary vein and pulmonary artery wedge pulse pressures.

Benadryl fails to protect against the histamine-provoked ulcer.

Conclusions 1. Benadryl fails to alter the gastric secretory response to histamine stimulation in pouch dogs. 2. Benadryl (given in 100 mg doses in beeswax mixture intramuscularly) fails to protect against the histamine-provoked ulcer in dogs.

Effects of benadryl on anaphylactic and histamine shock in rabbits and guinea pigs.

Summary 1. Benadryl offers effective protection against histamine shock in rabbits. 2. Benadryl did not protect against anaphylactic shock in rabbits sensitized to egg white. 3. Benadryl did not protect guinea pigs actively sensitized to egg white against anaphylaxis induced by intraperitoneal administration of the antigen under the dosage conditions employed.

Vagotomy Fails to Protect Against Histamine-Provoked Ulcer.

Conclusions 1. Bilateral vagotomy (infra- and supradiaphragmatic) failed to protect against ulcer or erosion (gastric and/or duodenal) produced by chronic histamine action in the dog, cat and rabbit.

II. Length of Afferent Duodenojejunal Loop in Gastric Resection, a Factor in Stomal Ulcer.

Conclusions Extensive gastric resection (75%) in dogs when accompanied by a long afferent duodenojejunal loop is followed by a high incidence of spontaneous gastrojejunal ulcer. When histamine in beeswax is administered to such dogs, stomal ulcer occurs regularly. When gastro-intestinal continuity is reestablished by a short afferent duodenal loop in the Billroth II plan of operation, stomal ulcer after extensive gastric resection (75%) can not be provoked even when histamine in beeswax is administered. It is obvious that a short afferent duodenal loop is an important component of a satisfactory operation when gastric resection on the Billroth II plan of operation is invoked in the surgical treatment of ulcer.