Ivan Fiore de Carvalho

Kinin-forming enzyme (kininogenin) in homogenates of rat kidney

Abstract An enzyme has been found in rat-kidney homogenates with the ability to release bradykinin or related peptides from plasma globulin. The system is normally inactive but can easily be activated in hypotonic media at pH 5.0. Centrifugation studies have shown that most of the enzymatic activity is concentrated in particles with the sedimentation characteristics of lysosomes or droplets. The sediment is inactive and can be activated by procedures used to release phosphate from lysosomes. The kidney enzyme has many properties of the urinary kallikrein found in rat urine.

Superoxide anion production by neutrophils is associated with prevalent clinical manifestations in systemic lupus erythematosus

To determine the relation between neutrophil function and the clinical characteristics of systemic lupus erythematosus (SLE), the superoxide anion (

THE BRADYKININOGEN CONTENT OF PLASMA FROM WOMEN IN LABOUR

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Systemic lupus erythematosus patients under immunosuppressive treatment express high levels of the immunoglobulin lambda variable IGLV8S1 gene with silent somatic mutations

) production by neutrophils, mediated by FcγR and FcγR/CR cooperation, was studied in 64 SLE patients classified according to their prevalent clinical manifestations. Three clinically distinct patterns were designated: (1) manifestations associated with the occurrence of cytotoxic antibodies (SLE-I group); (2) manifestations associated with circulating immune complexes (IC; SLE-II group), and (3) manifestations associated with IC and cytotoxic antibodies (SLE-III group).

A micromethod for determination of bradykininogen under several conditions.

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Evaluation of the role of complement and Fcγ receptors in the oxidative burst of neutrophils from the patients with active systemic lupus erythematosus

production was evaluated by a lucigenin-dependent chemiluminescent assay in neutrophils stimulated with IC-IgG opsonized or not with complement. No difference in