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Ivan Kompis

Hoffmann-La Roche

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Featured researches published by Ivan Kompis.

Advances in Experimental Medicine and Biology | 1993

Selective Inhibition of Dihydrofolate Reductase from Problem Human Pathogens

Rudolf L. Then; Peter Hartman; Ivan Kompis; D. Santi

Considerable changes in the prevalence and epidemiology of human pathogenic microorganisms have occurred over the last decade. Two main factors are responsible: 1 Resistance development, which is a particular concern among grampositive cocci, e.g. staphylococci1 2 The increased number of patients with impaired immuneresponse, highlighted by the spread of HIV, who suffer infections with opportunistic pathogens such as Pneumocystis carinii, Toxoplasma gondii, Mycobacterium avium and others.

Journal of Molecular Biology | 1997

A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance

Glenn E. Dale; Clemens Broger; Allan D’Arcy; Peter Hartman; Ronald DeHoogt; Synese Jolidon; Ivan Kompis; Alexander M. Labhardt; Hanno Langen; Hans Locher; Malcolm G. P. Page; Dietrich Stüber; Rudolf L. Then; Beat Wipf; Christian Oefner

Journal of Medicinal Chemistry | 1992

Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors

Christian Hubschwerlen; P. Pflieger; Jean-Luc Specklin; Klaus Gubernator; H. Gmuender; Peter Angehrn; Ivan Kompis

Helvetica Chimica Acta | 1980

15N-NMR. Studies of Aminopyridines, Aminopyrimidines and of Some Diazine N-Oxides†

Werner Städeli; Wolfgang von Philipsborn; Alexander E. Wick; Ivan Kompis

Helvetica Chimica Acta | 1977

Synthese von 4-halogensubstituierten Analogen von Trimethoprim

Ivan Kompis; Alexander E. Wick

Helvetica Chimica Acta | 1973

Chaenorhin, ein macrocyclisches Spermin-Alkaloid. 149. Mitteilung über Alkaloide†‡

Heinz O. Bernhard; Ivan Kompis; Siegfried Johne; Detlef Groöger; Manfred Hesse; Hans Schmid

Journal of Medicinal Chemistry | 1996

Synthesis and Structure−Activity Relationship of (Lactamylvinyl)cephalosporins Exhibiting Activity against Staphylococci, Pneumococci, and Enterococci

Ingrid Heinze-Krauss; Peter Angehrn; Philippe Guerry; Paul Hebeisen; Christian Hubschwerlen; Ivan Kompis; Malcolm G. P. Page; Hans Richter; Valerie Runtz; Henri Stalder; Urs Weiss; Chung-Chen Wei

Archive | 1981

2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines

Ivan Kompis; Gerald Rey-Bellet; Guido Zanetti

Helvetica Chimica Acta | 1972

Nachweis von Desacetylakuammilin und 10-Methoxy-desacetylakuammilin in Vinca minor L. 147. Mitteilung über Alkaloide†‡

Sabri Savaskan; Ivan Kompis; Manfred Hesse; Hans Schmid

Helvetica Chimica Acta | 1986

5‐(N‐Arylnortropan‐3‐yl)‐ and 5‐(N‐Arylpiperidin‐4‐yl)‐2,4‐diaminopyrimidines. Novel Inhibitors of Dihydrofolate Reductase

Hans Maag; Rita Locher; John J. Daly; Ivan Kompis

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Alexander E. Wick

Hoffmann-La Roche

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Rita Locher

Hoffmann-La Roche

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Ekkehard Weiss

Hoffmann-La Roche

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Hans Maag

Hoffmann-La Roche

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Christian Hubschwerlen

Hoffmann-La Roche

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Guido Zanetti

Hoffmann-La Roche

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Synese Jolidon

Hoffmann-La Roche

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Gerald Rey-Bellet

Hoffmann-La Roche

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Jean-Luc Specklin

Hoffmann-La Roche

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Alfredo Guerrato

Hoffmann-La Roche

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