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Dive into the research topics where Ivan Sobolev is active.

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Featured researches published by Ivan Sobolev.


Emerging Infectious Diseases | 2017

Novel Reassortant Clade 2.3.4.4 Avian Influenza A(H5N8) Virus in Wild Aquatic Birds, Russia, 2016

Dong-Hun Lee; Kirill Sharshov; David E. Swayne; Olga Kurskaya; Ivan Sobolev; Marsel R. Kabilov; Alexander Alekseev; Victor Irza; Shestopalov Am

The emergence of novel avian influenza viruses in migratory birds is of concern because of the potential for virus dissemination during fall migration. We report the identification of novel highly pathogenic avian influenza viruses of subtype H5N8, clade 2.3.4.4, and their reassortment with other avian influenza viruses in waterfowl and shorebirds of Siberia.


Infection, Genetics and Evolution | 2013

Monitoring of influenza viruses in Western Siberia in 2008–2012

T. Ilyicheva; Ivan Sobolev; Ivan M. Susloparov; O. Kurskaya; A. Durymanov; K. Sharshov; Shestopalov Am

Western Siberia is of great importance in ecology and epidemiology of influenza. This territory is nesting area for great amount of bird species. Territorial relations of Western Siberian birds that are established during seasonal migration are extremely wide since this region is an intersection point of bird migration flows wintering in different regions of the world: Europe, Africa, Middle East, Central Asia, Hindustan, and South East Asia. Reassortant influenza viruses that can cause outbreak among population may emerge in Western Siberia with high probability. Thus, it is extremely important to carry out widespread study of circulated viruses, their molecular biological properties, phylogenetic links in this region, as well as herd immunity to influenza virus serotypes with epidemic potential.


Virology | 2017

Five distinct reassortants of H5N6 highly pathogenic avian influenza A viruses affected Japan during the winter of 2016–2017

Nobuhiro Takemae; Ryota Tsunekuni; Kirill Sharshov; Taichiro Tanikawa; Yuko Uchida; Hiroshi Ito; Kosuke Soda; Tatsufumi Usui; Ivan Sobolev; Shestopalov Am; Tsuyoshi Yamaguchi; Junki Mine; Toshihiro Ito; Takehiko Saito

To elucidate the evolutionary pathway, we sequenced the entire genomes of 89 H5N6 highly pathogenic avian influenza viruses (HPAIVs) isolated in Japan during winter 2016-2017 and 117 AIV/HPAIVs isolated in Japan and Russia. Phylogenetic analysis showed that at least 5 distinct genotypes of H5N6 HPAIVs affected poultry and wild birds during that period. Japanese H5N6 isolates shared a common genetic ancestor in 6 of 8 genomic segments, and the PA and NS genes demonstrated 4 and 2 genetic origins, respectively. Six gene segments originated from a putative ancestral clade 2.3.4.4 H5N6 virus that was a possible genetic reassortant among Chinese clade 2.3.4.4 H5N6 HPAIVs. In addition, 2 NS clusters and a PA cluster in Japanese H5N6 HPAIVs originated from Chinese HPAIVs, whereas 3 distinct AIV-derived PA clusters were evident. These results suggest that migratory birds were important in the spread and genetic diversification of clade 2.3.4.4 H5 HPAIVs.


Infection, Genetics and Evolution | 2012

Molecular genetic analysis of influenza A/H3N2 virus strains isolated in Western Siberia in the 2010-2011 epidemic season.

Ivan Sobolev; Olga Kurskaya; Ivan M. Susloparov; T. Ilyicheva; Shestopalov Am

Molecular genetic and antigenic features of influenza A/H3N2 virus strains isolated in Western Siberia in 2011 are similar to those of the vaccine strain A/Perth/16/2009 despite a number of unique amino-acid changes. The strains lack specific amino-acid changes in NA protein providing decrease of sensibility to NA inhibitors activity that used in medical practice. Based on phylogenic analysis of HA protein amino-acid sequences examined strains are similar to influenza A/H3N2 virus strains circulating at the moment in Eurasia.


Genome Announcements | 2015

Complete Genome Sequence of Genotype Ib Newcastle Disease Virus Isolated from a Mallard (Anas platyrhynchos) in Russia

Kseniya S. Yurchenko; Ivan Sobolev; Alexandra V. Glushchenko; Alexander M. Shestopalov

ABSTRACT We report here the complete genome sequence of a Newcastle disease virus isolate, NDV/Yakutiya/mallard/852/2011, isolated from a mallard in Russia. On the basis of phylogenetic analysis, this strain was clustered into class II genotype Ib.


Infection, Genetics and Evolution | 2016

Adaptation of influenza A(H1N1)pdm09 virus in experimental mouse models

Elena A. Prokopyeva; Ivan Sobolev; M.V. Prokopyev; Alexander M. Shestopalov

In the present study, three mouse-adapted variants of influenza A(H1N1)pdm09 virus were obtained by lung-to-lung passages of BALB/c, C57BL/6z and CD1 mice. The significantly increased virulence and pathogenicity of all of the mouse-adapted variants induced 100% mortality in the adapted mice. Genetic analysis indicated that the increased virulence of all of the mouse-adapted variants reflected the incremental acquisition of several mutations in PB2, PB1, HA, NP, NA, and NS2 proteins. Identical amino acid substitutions were also detected in all of the mouse-adapted variants of A(H1N1)pdm09 virus, including PB2 (K251R), PB1 (V652A), NP (I353V), NA (I106V, N248D) and NS1 (G159E). Apparently, influenza A(H1N1)pdm09 virus easily adapted to the host after serial passages in the lungs, inducing 100% lethality in the last experimental group. However, cross-challenge revealed that not all adapted variants are pathogenic for different laboratory mice. Such important results should be considered when using the influenza mice model.


Journal of Veterinary Medical Science | 2017

Genetic characterization of an H2N2 influenza virus isolated from a muskrat in Western Siberia

Marina A. Gulyaeva; Kirill Sharshov; Mizuho Suzuki; Ivan Sobolev; Yoshihiro Sakoda; Alexander Alekseev; Mariya V. Sivay; Lidia V. Shestopalova; Michael Shchelkanov; Shestopalov Am

Thirty-two muskrats (Ondatra zibethicus) were captured for surveillance of avian influenza virus in wild waterfowl and mammals near Lake Chany, Western Siberia, Russia. A/muskrat/Russia/63/2014 (H2N2) was isolated from an apparently healthy muskrat using chicken embryos. Based on phylogenetic analysis, the hemagglutinin and neuraminidase genes of this isolate were classified into the Eurasian avian-like influenza virus clade and closely related to low pathogenic avian influenza viruses (LPAIVs) isolated from wild water birds in Italy and Sweden, respectively. Other internal genes were also closely related to LPAIVs isolated from Eurasian wild water birds. Results suggest that interspecies transmission of LPAIVs from wild water birds to semiaquatic mammals occurs, facilitating the spread and evolution of LPAIVs in wetland areas of Western Siberia.


Archives of Virology | 2016

Characterization of avian paramyxovirus type 6 isolated from a Eurasian teal in the intersection of migratory flyways in Russia.

Ivan Sobolev; Kirill Sharshov; Kseniya S. Yurchenko; Denis Korneev; Alexandra V. Glushchenko; Tatyana Y. Alikina; Marsel R. Kabilov; Yuhai Bi; Wenjun Liu; Natalia Gubanova; Shestopalov Am

The complete genome sequence was determined for avian paramyxovirus (APMV-6) serotype 6 strain teal/Chany/455/2009, isolated from a teal (Anas crecca) in Siberia. Siberia is crossed by four major migration flyways and represents the major breeding area for many wild bird species in the Palearctic. Strain teal/Chany/455/2009 is genetically closely related to Kazakh and Chinese strains and belongs to the genetic group of duck/Hong Kong/18/199/77-like APMV-6 viruses. We show that the virus has low pathogenic potential according to genetic markers and animal model experiments.


Virologica Sinica | 2018

Characterization of Avian-like Influenza A (H4N6) Virus Isolated from Caspian Seal in 2012

Marina A. Gulyaeva; Ivan Sobolev; Kirill Sharshov; Olga G. Kurskaya; Alexander Alekseev; Lidia V. Shestopalova; Anna V. Kovner; Yuhai Bi; Weifeng Shi; Michael Shchelkanov; Shestopalov Am

Marine mammals are widely distributed and can be found almost in all coastal waters and coastlines around the world. The interface areas between marine and terrestrial environments provide natural habitats for aquatic and semiaquatic mammals as well as for reservoir species of avian influenza viruses (AIV) (Runstadler et al. 2013). Previous studies showed that wild aquatic birds, the natural reservoir of AIV, are able to transmit the virus to various mammals, including seals, swine, horses, muskrats, and humans (Webster et al. 1992; Reperant et al. 2009; Gulyaeva et al. 2017). Close contacts between sea mammals and wild birds on breeding-grounds could promote both interspecies transmission of AIV and virus establishment in a new host (Fereidouni et al. 2014). Various AIV subtypes (A/seal/ Massachusetts/80(H7N7), A/Seal/MA/133/82(H4N5), A/Seal/MA/3807/91(H4N6), A/Seal/MA/3911/92(H3N3), A/harbour seal/Mass/1/2011(H3N8) and A/harbor seal/NL/ PV14-221_ThS/2015(H10N7) etc.) have been isolated from different species of marine mammals during the last 30 years. AIV isolated from marine mammals and wild birds are closely related, which suggests that wild birds are the major source of AIV infection (Fereidouni et al. 2014; Bodewes et al. 2015). In addition, AIV can cross species barrier and replicate well in experimental mammals without prior adaptation (Driskell et al. 2012).


PLOS ONE | 2018

Viral etiology of acute respiratory infections in hospitalized children in Novosibirsk City, Russia (2013 – 2017)

Olga G. Kurskaya; Tatyana Ryabichenko; Natalya Leonova; Weifeng Shi; Hongtao Bi; Kirill Sharshov; Eugenia Kazachkova; Ivan Sobolev; Elena A. Prokopyeva; Tatiana Kartseva; Alexander Alekseev; Shestopalov Am

Background Acute respiratory infections (ARIs) cause a considerable morbidity and mortality worldwide especially in children. However, there are few studies of the etiological structure of ARIs in Russia. In this work, we analyzed the etiology of ARIs in children (0–15 years old) admitted to Novosibirsk Children’s Municipal Clinical Hospital in 2013–2017. Methods We tested nasal and throat swabs of 1560 children with upper or lower respiratory infection for main respiratory viruses (influenza viruses A and B, parainfluenza virus types 1–4, respiratory syncytial virus, metapneumovirus, four human coronaviruses, rhinovirus, adenovirus and bocavirus) using a RT-PCR Kit. Results We detected 1128 (72.3%) samples were positive for at least one virus. The most frequently detected pathogens were respiratory syncytial virus (358/1560, 23.0%), influenza virus (344/1560, 22.1%), and rhinovirus (235/1560, 15.1%). Viral co-infections were found in 163 out of the 1128 (14.5%) positive samples. We detected significant decrease of the respiratory syncytial virus-infection incidence in children with increasing age, while the reverse relationship was observed for influenza viruses. Conclusions We evaluated the distribution of respiratory viruses in children with ARIs and showed the prevalence of respiratory syncytial virus and influenza virus in the etiological structure of infections. This study is important for the improvement and optimization of diagnostic tactics, control and prevention of the respiratory viral infections.

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Shestopalov Am

State Research Center of Virology and Biotechnology VECTOR

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Elena A. Prokopyeva

Novosibirsk State University

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Ivan M. Susloparov

State Research Center of Virology and Biotechnology VECTOR

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Marsel R. Kabilov

Russian Academy of Sciences

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T. Ilyicheva

Novosibirsk State University

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Alexander G. Durymanov

State Research Center of Virology and Biotechnology VECTOR

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Marina A. Gulyaeva

Novosibirsk State University

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