Ivan Vukovic
University of Belgrade
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Featured researches published by Ivan Vukovic.
Urologic Oncology-seminars and Original Investigations | 2013
Bogomir Milojevic; Milan Djokic; Sandra Sipetic-Grujicic; Isidora Grozdic Milojevic; Aleksandar Vuksanovic; Predrag Nikic; Ivan Vukovic; Dejan Djordjevic; Uros Bumbasirevic; Cane Tulic
OBJECTIVE To evaluate the prognostic factors for survival and disease recurrence in patients treated surgically for upper tract urothelial carcinoma (UTUC), focusing especially on the impact of history of non-muscle-invasive bladder cancer. PATIENTS AND METHODS A single-center series of 221 consecutive patients who were treated surgically for UTUC between January 1999 and December 2010 was evaluated. Patients who had a history of bladder tumor at a higher stage than the upper tract disease, preoperative chemotherapy, or previous contralateral UTUC were excluded. None of the patients included in this study had distant metastasis at diagnosis of UTUC. In total, 183 patients (mean age 66 years, range 36-88) were then available for evaluation. Tumor multifocality was defined as the synchronous presence of 2 or more pathologically confirmed tumors in any upper urinary tract location (renal pelvis or ureter). All patients were treated with either open radical nephroureterectomy (RNU) or open conservative surgery. Recurrence-free probabilities and cancer-specific survival were estimated using the Kaplan-Meier method and Cox regression analyses. RESULTS Fifty-one patients (28%) had previous carcinoma not invading bladder muscle. Previous history of non-muscle-invasive bladder cancer was significantly associated with tumor multifocality (P < 0.001), concomitant bladder cancer (P < 0.001), higher tumor stage (P = 0.020), and lymphovascular invasion (P = 0.026). Using univariate analyses, history of non-muscle-invasive bladder cancer was significantly associated with an increased risk of both any recurrence (HR = 2.17; P = 0.003) and bladder-only recurrence (HR = 3.17; P = 0.001). Previous carcinoma not invading bladder muscle (HR = 2.58; P = 0.042) was an independent predictor of bladder-only recurrence. Overall 5-year disease recurrence-free (any recurrence and bladder-only recurrence) survival rates were 66.7% and 77%, respectively. Previous history of non-muscle-invasive bladder cancer was not associated with cancer-specific survival. Our results are subject to the inherent biases associated with high-volume tertiary care centers. CONCLUSIONS Patients with previous history of non-muscle-invasive bladder cancer had a higher risk of having multifocal and UTUC with higher tumor stages (pT3 or greater). History of bladder tumor was an independent predictor of bladder cancer recurrence but had no effect on non-bladder recurrence, and cancer-specific survival in patients who underwent surgical treatment of UTUC.
BJUI | 2012
Bogomir Milojevic; Milan Djokic; Sandra Sipetic-Grujicic; Dragica Milenkovic-Petronic; Aleksandar Vuksanovic; Uros Bumbasirevic; Ivan Vukovic; Dejan Dragicevic; Cane Tulic
Study Type – Therapy (case series)
Journal of Surgical Oncology | 2015
Nebojsa Bojanic; Uros Bumbasirevic; Ivan Vukovic; Gordana Bojanic; Bogomir Milojevic; Djordje Nale; Otas Durutovic; Dejan Djordjevic; Predrag Nikic; Aleksandar Vuksanovic; Cane Tulic; Sava Micic
To assess the oncologic and functional outcomes of testicular sparing surgery (TSS) based on a single institution experience.
Journal of Surgical Oncology | 2017
Nebojsa Bojanic; Uros Bumbasirevic; Gordana Bojanic; Ivan Vukovic; Bogomir Milojevic; Tatjana Pekmezovic
To evaluate the results of testis‐sparing surgery (TSS) in patients, with small testicular lesions and a normal contralateral testicle.
Vojnosanitetski Pregled | 2006
Djordje Nale; Sava Micic; Ivan Vukovic; Radoslav Radosavljevic
BACKGROUND/AIM The part of the tunica albuginea that is not affected by localized pathological fibrosis is excised by the Nesbit contralateral excisional corporalplasty in patients with induratio penis plastica (IPP). The aim of this study was to find out if there were any histological changes of the macroscopically normal tunica albuginea excised during the Nesbit corporalplasty. METHODS A total of 31 patients, mean age 45 +/- 7.65 years, were surgical treated for extensive penile curvature (impossible or difficult penile imission in the vagina), using the Nesbit surgical technique. The tunica albuginea tissue was manipulated by Alliss clamps and excised in the shape of a diamond and placed in the 4% formaldehyde solution for histological analysis. The excised tunica albuginea was not wider than 1 cm, while the histological preparations were 3 to 5 microm thick, and they were stained with hematoxylin-eosin. The excised tunica albuginea tissue appeared macroscopically (anatomically) normal in all of the operated patients. In 28 (90.3%) patients opperated for dorsal curvature of the penis, the tissue of the tunica albuginea was excised from the urethral ridge, while in 3 (9.7%) patients operated for lateral curvature, the tissue was excised from the lateral corpus cavernosum. RESULTS The histological results were normal in 12 (38.7%) patients, while in 19 (61.3%) cases the findings indicated fibrosis of tunica albuginea. No significant difference in the patients age was found between these two groups (p = 0.09). The analysis of a total number of histological results of the patients with tunica albuginea fibrosis in relation to the patients with normal results showed that there was no significant difference (chi2 = 1,2; df = 1; p > 0.05), suggesting that the macroscopically normal tunica albuginea is not always expected to yield normal histological result. CONCLUSION Significantly more reported histological results of tunica albuginea fibrosis in the location that appeared normal macroscopically (chi2 = 27.5; df = 1; p < 0.01) indicated that, in the majority of IPP patients (61.3%), pathological lesion was diffusive with localized phenotypic expression plaque in the tunica albuginea, showing that, in the majority of cases noxa acted diffusely.
International Braz J Urol | 2017
Ivan Vukovic; Dejan Djordjevic; Nebojsa Bojanic; U. Babic; I. Soldatovic
Vojnosanitetski Pregled | 2009
Nebojsa Bojanic; Sava Micic; Aleksandar Vuksanovic; Ivan Vukovic; Aleksandar Janjic
Vojnosanitetski Pregled | 2017
Uros Babic; Ivan Soldatovic; Ivan Vukovic; S. Dragicevic; Dejan Djordjevic; Miodrag Acimovic; Veljko Santric; Zoran Dzamic; Aleksandar Vuksanovic
Vojnosanitetski Pregled | 2011
Nebojsa Bojanic; Djordje Nale; Sava Micic; Aleksandar Janicic; Aleksandar Vuksanovic; Ivan Vukovic
Urotoday International Journal | 2010
Sava Micic; Nebojsa Bojanic; Djordje Nale; Otas Durutovic; Ivan Vukovic; Natasa Lalic