Ivana Karmelić
University of Zagreb
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Featured researches published by Ivana Karmelić.
Archives of Medical Research | 2012
Ivana Karmelić; Jasna Lovrić; Tamara Božina; Hana Ljubić; Željka Vogrinc; Nada Božina; Jadranka Sertić
BACKGROUND AND AIMS Human obesity is accepted as an important risk factor for development of MetS. Adiponectin is linked to central obesity and ADIPOQ variants are promising markers for understanding the genetic base of obesity-related disorders. We performed analyses of adiponectin concentrations and ADIPOQ variants and tested their associations with obesity and MetS in young subjects of Croatian origin. METHODS Biochemical and anthropometric parameters of MetS were obtained for 149 unrelated subjects. Adiponectin levels were measured by ELISA assay. ADIPOQ -11391G>A and -11377C>G were genotyped by real-time PCR. RESULTS BMI and WC, TG and GLUC showed inverse correlation, whereas HDL-C showed a positive correlation with adiponectin concentrations. For central obesity, we found association with -11377C>G and with -11391G>A polymorphisms. ADIPOQ -11377GG and -11391GA significantly increased the risk for the development of central obesity (OR 5.57 and OR 3.37, respectively). Significant association was found between -11391A, -11377G allele and haplotype and increased TG. -11377C>G and -11391G>A variant were significantly associated with the incidence of MetS. C>G mutation at position -11377 significantly increased the risk of MetS development (OR = 2.93). Compared with the -11391G homozygotes, carriers of the A allele had a significantly increased risk for the development of MetS (OR = 3.15). The test of overall association showed a statistically significant correlation of MetS with -11377C>G and -11391G>A haplotypes (p = 0.008). CONCLUSIONS Analysis of adiponectin concentration and ADIPOQ -11391G>A and -11377C>G gene variants may be clinically meaningful for estimation of MetS risk in a young population.
Annals of Human Biology | 2017
Ivana Karmelić; Jasna Lovrić; Tamara Božina; Ana Merkler; Nada Božina; Jadranka Sertić
Abstract Background: Apolipoprotein E has an important role in lipid metabolism and adipocyte activity and apo E gene (APOE) might serve as a potential determinant of metabolic syndrome (MetS). Aim: The aim of the presented study was to investigate the association between APOE polymorphism and MetS in young adult subjects of Croatian origin. Methods: This study measured biochemical and anthropometric parameters of 149 young (aged 20–33) subjects. The APOE was genotyped by real-time PCR. Results: No APOE genotype significantly increased the risk for development of MetS. Significant association was found between APOE polymorphism and elevated blood pressure (EBP) (p = .019). The carriers of the ɛ4 allele had decreased risk for EBP (OR = 0.28, 95% CI) compared to ɛ3 allele carriers (ɛ3 allele vs others, χ2 = 7.08; p = .005). APOE alleles were significantly associated with the concentration of TC and LDL-C (χ2 = 12.11, p = .002 and χ2 = 15.76, p < .001, respectively). With diet as a modification covariate there was a significant correlation of APOE alleles with the concentrations of adiponectin and leptin (χ2 = 7.076; p = .029 and χ2 = 7.46; p = .024, respectively). Conclusion: Although APOE variants were not confirmed as the risk factor for development of MetS, the APOE alleles were associated with some of the metabolic parameters in young Croatian subjects. The relation of APOE alleles with a concentration of adiponectin and leptin depends on the diet intake.
Food Chemistry | 2007
Slavica Ribar; Lana Feher-Turković; Ivana Karmelić; Marko Mesarić
Food Research International | 2007
Slavica Ribar; Ivana Karmelić; Marko Mesarić
Mljekarstvo | 2006
Slavica Ribar; Ivana Karmelić; Marko Mesarić
Archive | 2017
Tamara Božina; Danijela Cvijanović; Vladimir Damjanović; Ivančica Delaš; Dragana Fabris; Blaženka Foretić; Svjetlana Kalanj Bognar; Ivana Karmelić; Jasna Lovrić; Kristina Mlinac Jerković; Daria Pašalić; Igor Picek; Slavica Potočki; Jadranka Sertić; Željka Vukelić
Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology on the Occasion of the 40th Anniversary (HDBMB 2016) | 2016
Ivana Karmelić; Tamara Božina; Nada Božina; Jasna Lovrić; Jadranka Sertić
16. Ružičkini dani DANAS ZNANOST-SUTRA INDUSTRIJA | 2016
Slavica Potočki; Ivana Karmelić
Archive | 2015
Jasna Lovrić; Ivana Karmelić
International Society for Applied Biological Sciences. Program and Abstracts. ISABS Conference on Forensic, Anthropologic Genetics and Mayo Clinic Lectures in Individualized Medicine/ Bol, Island of Brač, June 22-26, 2015. | 2015
Ivana Karmelić; Jasna Lovrić; Tamara Božina; Ana Merkler; Nada Božina; Jadranka Sertić