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Dive into the research topics where Ivana Likic is active.

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Featured researches published by Ivana Likic.


American Journal of Obstetrics and Gynecology | 2008

Analysis of urologic complications after radical hysterectomy

Ivana Likic; Sasa Kadija; Nebojsa Ladjevic; Aleksandar Stefanovic; Katarina Jeremic; Spasoje Petkovic; Zoran Dzamic

OBJECTIVE Injuries of the ureter or bladder or development of vesicovaginal and ureterovaginal fistulas are the most serious complications in gynecological surgery. STUDY DESIGN This study included 536 women who underwent radical hysterectomy because of invasive cancer of the cervix uteri. RESULTS During the surgery the ureter was injured in 1.32% of cases, whereas the percentage of bladder injuries was 1.49. In the early postoperative period vesicovaginal or ureterovaginal fistulas appeared in 2.61% and 2.43% of cases, respectively. CONCLUSION The stage of the disease, obesity, diabetes, and postoperative surgical infection acted as predisposing factors of the urinary tract complications.


Vojnosanitetski Pregled | 2011

EVALUATION OF ADNEXAL MASSES: CORRELATION BETWEEN CLINICAL, ULTRASOUND AND HISTOPATHOLOGICAL FINDINGS

Jelena Dotlic; Milan Terzic; Ivana Likic; Jasmina Atanackovic; Nebojsa Ladjevic

BACKGROUND/AIM Concerning the growth of ovarian carcinoma incidence and bad prognosis for malignant forms, early and precise diagnostics is gaining in importance as a condition for precise and appropriate therapy for ovarian tumor masses. The aim of this study was to analyze pre- and postoperative findings of patients with adnexal masses in order to identify factors which could predict the nature and stage of the tumor prior to surgery. METHODS All patients with adnexal masses who were treated in a 6-month period in the Institute of Obstetrics and Gynecology, Clinical Center of Serbia, (IOG, CCS), Belgrade, had their epidemiologic and gynecologic anamnesis and standard laboratory analyses taken prior to surgery. Also, clinical and ultrasonographic check up of pelvic organs was performed, as well as calculation of body mass index (BMI) and risk of malignancy index (RMI). After surgery we analyzed histopathological (HP) findings of tumors as a mean of final diagnosis and staging. For statistical analysis, we used SPSS 15 program. RESULTS Throughout a 6-month period, we examined 81 patients with adnexal masses treated in the IOG CCS. HP findings showed that there were significantly more benign (n = 51) than malignant (n = 30) tumors in all the patients (Chi2 = 5.512). The patients with malignant HP findings were significantly older than those with benign adnexal masses (t = 3.362; p = 0.001). Significantly more patients with malignant HP findings were in menopause (p = 0.034). BMI values were highly significantly higher in the patients with malignant adnexal tumors (t = 3.421; p = 0.001). There was a statistically significant positive correlation between HP categories (benign, malignant) and RMI categories (low, intermediate and high risk) of all the patients (high risk, more malignant HP) (Ro(xy) = 0.428; df = 78; p = 0.000). CONCLUSION . Patients in menopause, especially older ones, with high BMI and RMI should immediately be referred to a tertiary level institution, where appropriate surgery could be performed.


Taiwanese Journal of Obstetrics & Gynecology | 2013

Risk of malignancy index validity assessment in premenopausal and postmenopausal women with adnexal tumors

Milan Terzic; Jelena Dotlic; Ivana Likic; Natasa Brndusic; Igor Pilic; Nebojsa Ladjevic; Sanja Maricic; Nebojsa Arsenovic; Zoran Maricic

OBJECTIVE The aim of this study was to investigate the validity of the risk of malignancy index (RMI) in premenopausal and postmenopausal patients with adnexal masses. MATERIALS AND METHODS The study involved all women treated for adnexal tumors throughout an 18-month period in the Clinic for Gynecology and Obstetrics, Clinical Center of Serbia (Belgrade, Serbia). On admission, detailed anamnestic and laboratory data were obtained and an expert ultrasound scan was performed. The RMI was calculated for all patients and the obtained data were related to histopathological findings of the tumors. For statistical analysis, we used descriptive and analytical statistics methods and an SPSS computer program. RESULTS From a total number of 540 women, 85 women had malignant tumors; 20 women, borderline tumors; and 435 women, benign adnexal tumors. The RMI was reliable in 84.6% of all patients; in 77% of premenopausal patients, and in 81.1% of postmenopausal patients. The sensitivity of the RMI in the overall population was 83.81%; the specificity was 77.24%; the positive predictive value (PPV) was 47.06%, and the negative predictive value (NPV) was 95.18%. In premenopausal women, the RMI sensitivity was 83.87%; specificity, 80.31%; PPV, 28.89%; and NPV, 98.12%. In postmenopausal women the RMI sensitivity was 83.78%; specificity, 68.18%; PPV, 63.92%; and NPV, 74.71%. CONCLUSION The RMI was a reliable factor for differentiating benign from malignant adnexal masses in premenopausal and postmenopausal patients.


Chinese Journal of Cancer Research | 2013

Current diagnostic approach to patients with adnexal masses: which tools are relevant in routine praxis?

Milan Terzic; Jelena Dotlic; Ivana Likic; Nebojsa Ladjevic; Natasa Brndusic; Nebojsa Arsenovic; Sanja Maricic; Tihomir Mihailovic; Sasa Andrijasevic

OBJECTIVE The aim of the study was to investigate which anamnestic, laboratory and ultrasound parameters used in routine practice could predict the nature of adnexal mass, thus enabling referral to relevant specialist. METHODS Study involved the women treated for adnexal tumors throughout a period of 2 years. On admission, detailed anamnestic and laboratory data were obtained, expert ultrasound scan was performed, and power Doppler index (PDI), risk of malignancy index (RMI) and body mass index (BMI) were calculated for all patients. Obtained data were related to histopathological findings, and statistically analyzed. RESULTS The study included 689 women (112 malignant, 544 benignant, and 33 borderline tumors). Malignant and borderline tumors were more frequent in postmenopausal women (P=0.000). Women who had benignant tumors had the lowest BMI (P=0.000). There were significant (P<0.05) differences among tumor types regarding erythrocyte sedimentation rate, CA125 and carcinoembryonic antigen (CEA) levels. Among ultrasound findings, larger tumor diameter and ascites were more frequent in malignant tumors (P=0.000). Women with malignant tumors had highest values of RMI and PDI (P=0.000). CONCLUSIONS Anamnestic data, ultrasound parameters and laboratory analyses were all found to be good discriminating factors among malignant, benignant and borderline tumors.


Open Medicine | 2014

Diagnostic value of serum tumor markers for adnexal masses

Milan Terzic; Jelena Dotlic; Ivana Likic; Branka Nikolic; Natasa Brndusic; Igor Pilic; Jovan Bila; Sanja Maricic; Nebojsa Arsenovic

ObjectiveThe study aim was to investigate the diagnostic value of measuring preoperative serum tumor markers in patients with adnexal masses.MethodsThe study included all (358) consecutive patients treated for adnexal tumors at the Clinic of Obstetrics and Gynecology, Clinical Center of Serbia during 12 months. Tumor-marker levels (Ca 125, CEA, HE 4, Ca 19.9 and Ca 15.3) obtained from all women on admission were compared with histopathological findings in cases in which tumors were removed.ResultsWomen with malignant tumors had the highest levels of Ca 125, CEA and HE 4 (p<0.01). Mucinous adenocarcinoma produced the highest amounts of Ca 19.9 and CEA. Ca 15.3 was the highest in women with endometrioid carcinoma. There were no significant differences in the levels of all serum tumor markers between women with benign and borderline tumors (p>0.05). Malignant forms of tumors were well indicated by Ca 125, HE 4 and Ca 15.3 levels. The combination of Ca 125 and HE 4 resulted in the highest sensitivity, specificity, and positive or negative predictive value (91.04%, 87.6%, 67.9%, 77.2%, respectively).ConclusionsBlood levels of tumor markers can be effective? predictors of the nature of adnexal masses. For the most precise evaluation, a combination of serum tumor markers should be used.


Open Medicine | 2013

Diagnostic value of serum tumor markers evaluation for adnexal masses

Milan Terzic; Jelena Dotlic; Ivana Likic; Branka Nikolic; Natasa Brndusic; Igor Pilic; Jovan Bila; Sanja Maricic; Nebojsa Arsenovic

ObjectiveThe study aim was to investigate the diagnostic value of preoperative serum tumor markers in patients with adnexal masses.MethodsStudy included all (358) consecutive patients treated for adnexal tumors at the Clinic of Ob/Gyn, Clinical Center of Serbia in 12 months. Tumor marker levels (Ca 125, CEA, HE 4, Ca 19.9, and Ca 15.3), taken from all women on admission, were compared with postoperative histopathological findings of extracted tumors. Results. Women with malignant tumors had the highest levels of Ca 125, CEA, and HE 4 (p<0.01). Mucinous adenocarcinoma produced the highest amounts of Ca 19.9 and CEA. Ca 15.3 was the highest in women with endometrioid carcinoma. There were no significant differences in the levels of all examined tumor markers (p>0.05) between women with benign and borderline tumors. Ca 125, HE 4, and Ca 15.3 can discriminate the malignant from other tumor types well. The highest sensitivity, specificity, positive and negative predictive values (91.04%, 87.6%, 67.9%, 77.2%, respectively) were achieved for the combination of Ca 125 and HE 4.ConclusionsBlood levels of examined tumor markers can be good predictors of the adnexal masses nature. For the most precise evaluation the combination of serum tumor markers should be used.


Clinical and Experimental Obstetrics & Gynecology | 2012

Conservative management of massive hematoperitoneum caused by ovulation in a patient with severe form of von Willebrand disease--a case report.

Milan Terzic; Ivana Likic; Igor Pilic; Jovan Bila; N. Knezevic


European Journal of Gynaecological Oncology | 2009

Radical abdominal trachelectomy in managing early cervical invasion.

Jeremić K; Petković S; Stefanović A; Stojnic J; Maksimović M; Ivana Likic; Atanacković J


Ginekologia Polska | 2013

Histopathological diagnoses of adnexal masses: which parameters are relevant in preoperative assessment?

Milan Terzic; Jelena Dotlic; Natasa Brndusic; Ivana Likic; Sasa Andrijasevic; Nebojsa Arsenovic; Nebojsa Ladjevic; Sanja Maricic


European Journal of Gynaecological Oncology | 2013

Predictive factors of malignancy in patients with adnexal masses.

Milan Terzic; Jelena Dotlic; Ivana Likic; Nebojsa Ladjevic; Natasa Brndusic; Tihomir Mihailovic; Sasa Andrijasevic; Igor Pilic; Jovan Bila

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Jovan Bila

University of Belgrade

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Sasa Kadija

University of Belgrade

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