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American Journal of Cardiology | 1986

Comparative efficacy of high-dose versus low-dose nicorandil therapy for chronic stable angina pectoris

Masahiko Kinoshita; Shunsuke Nishikawa; Matsuhiko Sawamura; Shinichiro Yamaguchi; Kenichi Mitsunami; Makoto Itoh; Masakazu Motomura; Keizo Bito; Iwao Mashiro; Seiichi Kawakita

Nicorandil therapy was compared with placebo therapy in 11 patients with chronic stable angina pectoris. A computer-assisted treadmill exercise test was performed after administration of either 10 or 30 mg of nicorandil. Analysis of variance showed a significant difference among placebo and nicorandil treatments (p less than 0.01). Ten milligrams of nicorandil prolonged time to onset of ischemia 36% (p less than 0.05) but increased the exercise duration only 15%. Thirty milligrams of nicorandil prolonged time to onset of ischemia 82% (p less than 0.01) and exercise duration 45% (p less than 0.01). Both time to onset of ischemia and exercise duration increased progressively from the 10-mg to the 30-mg dose (p less than 0.05). Heart rate at rest was significantly higher and systolic pressure at rest significantly lower with 30 mg of nicorandil than with placebo. After administration of 30 mg of nicorandil there was a significant reduction in ST depression associated with a slight decrease in the double product at the end of Bruce stage 2 exercise. The peak double product was greater after administration of 30 mg of nicorandil than after placebo, indicating an increased myocardial oxygen supply to the ischemic area. The plasma concentration of nicorandil averaged 78 +/- 83 ng/ml with the 10 mg and 313 +/- 142 ng/ml with 30 mg. There was an increase in exercise duration of more than 1 minute in 8 of 9 patients who had plasma nicorandil concentrations greater than 100 ng/ml.(ABSTRACT TRUNCATED AT 250 WORDS)


Circulation | 1976

THE CHARACTERISTICS OF DIASTOLIC PRESSURE-VOLUME RELATIONSHIPS IN PRIMARY MYOCARDIAL DISEASE

Reizo Kusukawa; Tsuneo Hoshino; Go Tomonaga; Iwao Mashiro; Yukio Shimono; Masahiko Kinoshita


American Journal of Physiology-heart and Circulatory Physiology | 1978

Left and right ventricular dimensions during ventricular fibrillation in the dog

Iwao Mashiro; Jay N. Cohn; Richard Heckel; Richard R. Nelson; Joseph A. Franciosa


Clinical Cardiology | 1988

Clinicopharmacological studies of a newly synthesized cardiotonic agent (TA‐064) in patients with congestive heart failure

Keizo Bito; Masahiko Kinoshita; Iwao Mashiro; Nobuyuki Ozaki; Sakoda S; Tsutamoto T; Masakazu Motomura; Kenichi Mitsunami; Takehisa Fukuhara; Seiichi Kawakita


Japanese Circulation Journal-english Edition | 1975

COMPARISON OF MEASUREMENTS OF LEFT VENTRICLE BY ECHOGRAPHY AND CINEANGIOGRAPHY

Iwao Mashiro; Masahiko Kinoshita; Tomonaga G; Tsuneo Hoshino; Reizo Kusukawa


Japanese Circulation Journal-english Edition | 1980

PROTECTION OF CORONARY REPERFUSION INJURY BY A CALCIUM ANTAGONIST

Masahiko Kinoshita; Yukio Takayama; Shotaro Kato; Iwao Mashiro; Kenichi Mitsunami; Masakazu Motomura; Seiichi Kawakita; Atsumi Mori; Jun Sono; Yoshio Okada; Mizuo Miyazaki; Hideki Okunishi; Noboru Toda


Japanese Circulation Journal-english Edition | 1975

Echocardiographic observations in hypertension.

Iwao Mashiro; Masahiko Kinoshita; Tomonaga G; Tsuneo Hoshino; Yukio Shimono


Japanese Circulation Journal-english Edition | 1981

Site of premature ventricular contractions demonstrated by echocardiography.

Iwao Mashiro; Richard Heckel; Richard R. Nelson; Jay N. Cohn; Joseph A. Franciosa


Japanese Circulation Journal-english Edition | 1985

BENEFICIAL EFFECT OF DILTIAZEM ON ISCHEMIA-REPERFUSION INJURY IN THE DOG

Masahiko Kinoshita; Keizo Bito; Iwao Mashiro; Kenichi Mitsunami; Takehisa Fukuhara; Seiichi Kawaketa


Japanese Circulation Journal-english Edition | 1982

Left and right ventricular pressure diameter relationships during ventricular standstill in the dog.

Iwao Mashiro; Kenichi Mitsunami; Masahiko Kinoshita; Seiichi Kawakita; Gyozan Yamazaki; Richard Heckel; Jaseph A. Franciosa; Jay N. Cohn

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Masahiko Kinoshita

Shiga University of Medical Science

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Kenichi Mitsunami

Shiga University of Medical Science

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Seiichi Kawakita

Shiga University of Medical Science

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Masakazu Motomura

Shiga University of Medical Science

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Keizo Bito

Shiga University of Medical Science

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Takehisa Fukuhara

Shiga University of Medical Science

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Nobuyuki Ozaki

Shiga University of Medical Science

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Makoto Itoh

Shiga University of Medical Science

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