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J A Beavo

University of Washington

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Publication

Featured researches published by J A Beavo.

BMC Pharmacology | 2011

cGMP kinase I, cardiac hypertrophy and PDE inhibition

Enrico Patrucco; Robert Lukowski; Sergei D. Rybalkin; J A Beavo; Franz Hofmann

Background The heart responds to maladaptive pro-hypertrophic stimuli by stimulating intrinsic signals that contrast and dampen the onset and development of hypertrophy. Cyclic guanosine monophosphate (cGMP) and its downstream effector cGMP kinase I (cGKI) have been suggested to be an important anti-hypertrophic signalling pathway (1). Intracellular levels of cGMP can be raised by the action of nitric oxide (NO) and natriuretic peptides (ANP, BNP), or by inhibiting cGMP-degrading phosphodiesterases (PDE).

Journal of Biological Chemistry | 1982

Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues.

T J Martins; M C Mumby; J A Beavo

Proceedings of the National Academy of Sciences of the United States of America | 1998

Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase

Scott H. Soderling; Sharon J. Bayuga; J A Beavo

Journal of Biological Chemistry | 1988

Characterization of a Bovine Cone Photoreceptor Phosphodiesterase Purified by Cyclic GMP-Sepharose Chromatography*

Peter G. Gillespie; J A Beavo

Proceedings of the National Academy of Sciences of the United States of America | 1995

Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons

Chen Yan; Allan Z. Zhao; J. K. Bentley; K. Loughney; K. Ferguson; J A Beavo

Proceedings of the National Academy of Sciences of the United States of America | 2000

Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase

Joanna Hetman; Scott H. Soderling; Natalie Glavas; J A Beavo

Reviews of Physiology Biochemistry and Pharmacology | 1999

Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs)

D. M. Juilfs; Scott H. Soderling; F. Burns; J A Beavo

Proceedings of the National Academy of Sciences of the United States of America | 1989

cGMP is tightly bound to bovine retinal rod phosphodiesterase

Peter G. Gillespie; J A Beavo

Journal of Biological Chemistry | 1985

cGMP phosphodiesterase in rod and cone outer segments of the retina.

Richard L. Hurwitz; A H Bunt-Milam; M L Chang; J A Beavo

Journal of Biological Chemistry | 1995

An Essential Aspartic Acid at Each of Two Allosteric cGMP-binding Sites of a cGMP-specific Phosphodiesterase*

Linda M. McAllister-Lucas; Tamara L. Haik; Janet L. Colbran; William K. Sonnenburg; Dalia Seger; Illarion V. Turko; J A Beavo; Sharron H. Francis; Jackie D. Corbin

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Richard L. Hurwitz

Baylor College of Medicine

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William K. Sonnenburg

University of Washington

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Dalia Seger

University of Washington

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Peter G. Gillespie

Oregon Health

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Scott H. Soderling

Duke University

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Sergei D. Rybalkin

University of Washington

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A H Bunt-Milam

University of Washington

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Harry Charbonneau

Purdue University

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A Kadlecek

University of Washington

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Allan Z. Zhao

University of Pittsburgh

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