J A Rudbach

A quantitative estimation of sodium deoxycholate remaining in reassociated, hybrid endotoxins.

Summary Endotoxins which had been dissociated by sodium deoxycholate (NaD) and reassociated into hybrids still contained 1.5 to 7% surfactant. Control mixtures which were treated separately with NaD and did not form hybrids contained 2.2 to 8.5% NaD after two extractions with ethanol. When the amount of NaD remaining in the sample was calculated as percentage of that originally added, the ethanol extractions removed all but 0.2 to 0.5%.

Use of Monophosphoryl Lipid A as a Prophylactic for Sepsis and Shock

Of patients who ultimately develop gram-negative sepsis and shock, many can be identified for inclusion into high-risk groups [1–3]. These groups include patients subjected to certain types of surgeries, some with traumatic injuries, and those with depressed immune systems. Appropriate immunomodulation of patients in these groups should be able to prevent or ameliorate septic shock.