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Featured researches published by J.B. Szender.


International Journal of Gynecological Cancer | 2015

Oral Contraceptive Use and Reproductive Characteristics Affect Survival in Patients With Epithelial Ovarian Cancer: A Cohort Study.

Nonna Kolomeyevskaya; J.B. Szender; Gary Zirpoli; Albina N. Minlikeeva; Grace Friel; Rikki Cannioto; R. Brightwell; K.S. Grzankowski; Kirsten B. Moysich

Objectives Prognostic risk factors influencing survival in patients with epithelial ovarian cancer (EOC) include tumor stage, grade, histologic subtype, debulking, and platinum status. Little is known about the impact of hormonal milieu and reproductive factors before cancer diagnosis on clinical outcome. We sought to evaluate whether oral contraceptive (OC) use carries any prognostic significance on overall survival (OS) in patients with EOC. Methods Newly diagnosed patients with EOC, fallopian tube, and primary peritoneal cancers between 1982 and 1998 were prospectively evaluated with a comprehensive epidemiologic questionnaire. A retrospective chart review was performed to abstract clinicopathologic data, including OS. A Kaplan-Meier analysis was performed to compare survival across various exposures. A Cox regression model was used to compute adjusted hazards ratios (aHRs) and 95% confidence intervals (CIs). Results We identified 387 newly diagnosed cancers with evaluable information in this cohort. Decreased risk of death was observed in women who reported prior use of OC (aHR, 0.79; 95% CI, 0.58–1.09), previous pregnancy (aHR, 0.77; 95% CI, 0.57–1.04), or a live birth (aHR, 0.81; 95% CI, 0.60–1.08) after adjusting for age at diagnosis, stage, and histologic subtype. Oral contraceptive use was associated with a crude reduced risk of death (HR, 0.55; 95% CI, 0.42–0.72), with reported median OS of 81 months in OC users versus 46 months in nonusers. Patients who reported a single live birth experienced the largest potential survival advantage (aHR, 0.61; 95% CI, 0.39–0.94). Oral contraceptive use and prior pregnancy were associated with improved survival across all strata. Conclusions Oral contraceptive use may have lasting effects on epithelial ovarian tumor characteristics conferring favorable prognosis. Putative mechanisms that affect tumor biology include complex interactions between ovarian cells, host immune cells, and hormonal microenvironment during carcinogenesis. Future efforts should be directed to determine the role of reproductive factors in antitumor immunity.


Journal of Lower Genital Tract Disease | 2016

Impact of Physical Inactivity on Risk of Developing Cancer of the Uterine Cervix: A Case-Control Study.

J.B. Szender; Rikki Cannioto; Nicolas R. Gulati; Kristina Schmitt; Grace Friel; Albina N. Minlikeeva; A. Platek; Emily H. Gower; Ryan Nagy; Edgar Khachatryan; P.C. Mayor; Karin A. Kasza; Shashikant Lele; Kunle Odunsi; Kirsten B. Moysich

Objective In this study, we investigated whether physical inactivity was associated with risk of cervical cancer in women treated at an American cancer hospital. Methods This case-control study included 128 patients with cervical cancer and 512 controls matched on age. Controls were women suspected of having but not ultimately diagnosed with a neoplasm. Physical inactivity was defined in accordance with the 2008 Physical Activity Guidelines for Americans. Thus, participants reporting, on average, no moderate or vigorous recreational physical activity were classified as inactive. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results Compared with noncancer controls, those with cervical cancer had significantly increased odds of reporting abstinence from recreational physical activity (OR, 2.43; 95% CI, 1.56–3.80). No association was noted between occupational-related physical inactivity and cervical cancer (OR, 0.88; 95% CI, 0.58–1.36). Conclusions Our findings suggest that abstinence from regular recreational physical activity is associated with increased odds of cervical cancer. To our knowledge, this is the first US-based study examining these associations. Given the 2008 Physical Activity Guidelines for Americans, this study has identified yet another potential public health benefit to regular physical activity. Further investigation is needed using a larger sample and prospectively collected data to characterize dose of activity to mitigate risk and the optimal window of susceptibility.


Cancer Epidemiology | 2017

The association of lifetime physical inactivity with bladder and renal cancer risk: A hospital-based case-control analysis

Rikki Cannioto; John Lewis Etter; Lauren Beryl Guterman; Janine M. Joseph; Nicholas R. Gulati; Kristina L. Schmitt; Michael J. LaMonte; Ryan Nagy; Albina N. Minlikeeva; J.B. Szender; Kirsten B. Moysich

OBJECTIVES Recreational physical inactivity has been gaining recognition as an independent epidemiological exposure of interest in relation to cancer endpoints due to evidence suggesting that it may associate with cancer independent of obesity. In the current analyses, we examined the associations of lifetime recreational physical inactivity with renal and bladder cancer risk. METHODS In this hospital-based case-control study, we identified N=160 renal cancer patients, N=208 bladder cancer patients, and N=766 age frequency-matched controls without cancer. Participants self-reporting never participating in any regular/weekly recreational physical activity throughout their lifetime were classified as physically inactive. Utilizing unconditional multivariable logistic regression analyses, we estimated odds ratios and 95% confidence intervals to represent the associations between lifetime physical inactivity and renal and bladder cancer risk. RESULTS In multivariable logistic regression models, we observed significant positive associations between lifetime recreational physical inactivity and renal cancer and bladder cancer risk: odds ratio=1.77 (95% CI: 1.10-2.85) and odds ratio=1.73 (95% CI: 1.13-2.63), respectively. Similar associations also persisted among individuals who were not obese for both renal and bladder cancer: odds ratio=1.75 (95% CI: 1.03-2.98) and odds ratio=1.70 (95% CI: 1.08-2.69), respectively. CONCLUSIONS In this case-control study, we observed evidence of a positive association between renal and bladder cancer with lifetime recreational physical inactivity. These data add to the growing body of evidence suggesting that physical inactivity may be an important independent risk factor for cancer. However, additional studies using a larger sample and prospectively collected data are needed to substantiate the current findings.


Gynecologic Oncology | 2018

Variability in body mass index (BMI) during adjuvant chemotherapy is associated with clinical outcomes among invasive ovarian cancer patients

Kristen Starbuck; Rikki Cannioto; John Lewis Etter; Kirsten B. Moysich; W. Duncan; K. Morrell; H. Almohanna; J.M. Joseph; J.B. Szender; Emese Zsiros; Kunle Odunsi; P.J. Frederick; S.B. Lele; S.N. Akers; Kevin H. Eng


Gynecologic Oncology | 2018

Joint exposure to smoking, excessive weight, and physical inactivity affects survival of ovarian cancer patients: Evidence from the Ovarian Cancer Association Consortium

A.N. Minlikeeva; Rikki Cannioto; J.B. Szender; P.C. Mayor; Allan Jensen; Susanne K. Kjaer; Penelope M. Webb; Kirsten B. Moysich


Gynecologic Oncology | 2018

Prognostic impact of adjuvant chemotherapy treatment delays for ovarian cancer: A cohort study

Kristen Starbuck; Kevin H. Eng; K. Morrell; W. Duncan; John Lewis Etter; Kirsten B. Moysich; Kunle Odunsi; Emese Zsiros; P.J. Frederick; S.N. Akers; S.B. Lele; J.B. Szender


Gynecologic Oncology | 2018

Performing combined breast and gynecologic surgery does not increase the rate of postoperative morbidity

P.C. Mayor; K. Fan; John Lewis Etter; K. Morrell; Kevin H. Eng; J.B. Szender; S.N. Akers; P.J. Frederick; S.B. Lele; Kunle Odunsi; Emese Zsiros


Gynecologic Oncology | 2018

TIGIT ligands CD155, CD112, and galectin-9 are associated with immune infiltration and increased overall survival in ovarian cancer

Kristen Starbuck; K. Morrell; Kunle Odunsi; Emese Zsiros; J.B. Szender; P.J. Frederick; S.B. Lele; S.N. Akers; Kevin H. Eng


Gynecologic Oncology | 2018

Operative time is a major modifiable risk factor impacting surgical outcomes in patients undergoing pelvic exenteration for gynecologic malignancy

P.C. Mayor; K. Fan; John Lewis Etter; J.B. Szender; K. Morrell; Kevin H. Eng; S.N. Akers; P.J. Frederick; Kunle Odunsi; S.B. Lele; Emese Zsiros


Journal of Clinical Oncology | 2017

Performing combined breast and gynecologic surgery does not increase the rate of surgical site infections: A NSQIP database analysis.

P.C. Mayor; John Lewis Etter; J.B. Szender; Emese Zsiros; P.J. Frederick; Shashikant Lele

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Kunle Odunsi

Roswell Park Cancer Institute

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S.B. Lele

Roswell Park Cancer Institute

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P.J. Frederick

Roswell Park Cancer Institute

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Emese Zsiros

Roswell Park Cancer Institute

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K.S. Grzankowski

Roswell Park Cancer Institute

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P.C. Mayor

Roswell Park Cancer Institute

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Kevin H. Eng

Roswell Park Cancer Institute

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Kirsten B. Moysich

Roswell Park Cancer Institute

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S.N. Akers

Roswell Park Cancer Institute

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John Lewis Etter

Roswell Park Cancer Institute

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