J.C. Dykes
Stanford University
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Publication
Featured researches published by J.C. Dykes.
European Heart Journal | 2017
S. Chen; J.C. Dykes; Doff B. McElhinney; Robert J. Gajarski; Andrew Y. Shin; Seth A. Hollander; Melanie E Everitt; Jack F. Price; Ravi R. Thiagarajan; Steven J. Kindel; Joseph W. Rossano; Beth D. Kaufman; Lindsay J. May; Elizabeth Pruitt; David N. Rosenthal; Christopher S. Almond
Aims To evaluate associations between haemodynamic profiles and symptoms, end-organ function and outcome in children listed for heart transplantation. Methods and results Children <18 years listed for heart transplant between 1993 and 2013 with cardiac catheterization data [pulmonary capillary wedge pressure (PCWP), right atrial pressure (RAP), and cardiac index (CI)] in the Pediatric Heart Transplant Study database were included. Outcomes were New York Heart Association (NYHA)/Ross classification, renal and hepatic dysfunction, and death or clinical deterioration while on waitlist. Among 1059 children analysed, median age was 6.9 years and 46% had dilated cardiomyopathy. Overall, 58% had congestion (PCWP >15 mmHg), 28% had severe congestion (PCWP >22 mmHg), and 22% low cardiac output (CI < 2.2 L/min/m2). Twenty-one per cent met the primary outcome of death (9%) or clinical deterioration (12%). In multivariable analysis, worse NYHA/Ross classification was associated with increased PCWP [odds ratio (OR) 1.03, 95% confidence interval (95% CI) 1.01-1.07, P = 0.01], renal dysfunction with increased RAP (OR 1.04, 95% CI 1.01-1.08, P = 0.007), and hepatic dysfunction with both increased PCWP (OR 1.03, 95% CI 1.01-1.06, P < 0.001) and increased RAP (OR 1.09, 95% CI 1.06-1.12, P < 0.001). There were no associations with low output. Death or clinical deterioration was associated with severe congestion (OR 1.6, 95% CI 1.2-2.2, P = 0.002), but not with CI alone. However, children with both low output and severe congestion were at highest risk (OR 1.9, 95% CI 1.1-3.5, P = 0.03). Conclusion Congestion is more common than low cardiac output in children with end-stage heart failure and correlates with NYHA/Ross classification and end-organ dysfunction. Children with both congestion and low output have the highest risk of death or clinical deterioration.
The Annals of Thoracic Surgery | 2017
J.C. Dykes; Olaf Reinhartz; Christopher S. Almond; Vamsi Yarlagadda; J. Murray; David N. Rosenthal; Katsuhide Maeda
We report an infant with hypertrophic cardiomyopathy who underwent biventricular assist device placement with two 15-mL Berlin Heart EXCOR pediatric ventricular assist devices using an alternative atrial cannulation strategy. The systemic circulation was supported by left atrium (LA) to aorta cannulation. The LA was accessed through the right atrium by extending a 6-mm EXCOR cannula with a Gore-Tex graft connected to an atrial septal defect. The pulmonary circulation was supported with cannulation of the right atrium to pulmonary artery. This alternative cannulation strategy facilitated effective biventricular support and may be applicable to other patients with hypertrophic or restrictive physiology.
Journal of Heart and Lung Transplantation | 2017
Anica Bulic; Katsuhide Maeda; Yulin Zhang; Sharon Chen; Doff B. McElhinney; J.C. Dykes; Amanda M. Hollander; Seth A. Hollander; J. Murray; Olaf Reinhartz; Mary Alice Gowan; David N. Rosenthal; Christopher S. Almond
BACKGROUND As survival with pediatric left ventricular assist devices (LVADs) has improved, decisions regarding the optimal support strategy may depend more on quality of life and functional status (FS) rather than mortality alone. Limited data are available regarding the FS of children supported with LVADs. We sought to compare the FS of children supported with LVADs vs vasoactive infusions to inform decision making around support strategies. METHODS Organ Procurement and Transplant Network data were used to identify all United States children aged between 1 and 21 years at heart transplant (HT) between 2006 and 2015 for dilated cardiomyopathy and supported with an LVAD or vasoactive infusions alone at HT. FS was measured using the 10-point Karnofsky and Lansky scale. RESULTS Of 701 children who met the inclusion criteria, 430 (61%) were supported with vasoactive infusions, and 271 (39%) were supported with an LVAD at HT. Children in the LVAD group had higher median FS scores at HT than children in the vasoactive infusion group (6 vs 5, p < 0.001) but lower FS scores at listing (4 vs 6, p < 0.001). The effect persisted regardless of patient location at HT (home, hospital, intensive care) or device type. Discharge by HT occurred in 46% of children in the LVAD group compared with 26% of children in the vasoactive infusion cohort (p = 0.001). Stroke was reported at HT in 3% of children in the LVAD cohort and in 1% in the vasoactive infusion cohort (p = 0.04). CONCLUSIONS Among children with dilated cardiomyopathy undergoing HT, children supported with LVADs at HT have higher FS than children supported with vasoactive infusions at HT, regardless of device type or hospitalization status. Children supported with LVADs at HT were more likely to be discharged from the hospital but had a higher prevalence of stroke at HT.
The Annals of Thoracic Surgery | 2018
Katsuhide Maeda; Teimour Nasirov; David N. Rosenthal; J.C. Dykes
Hypertrophic cardiomyopathy is known to be difficult to support by left ventricular assist device because of the small ventricular cavity and inadequate drainage. Therefore, instead of cannulating on the left ventricular apex, a HeartWare ventricular assist device (HeartWare, Framingham, MA) was connected to the left atrium through right atrium onto atrial septum using ringed Gore-Tex (W.L. Gore & Associates, Flagstaff, AZ) interposition graft. The patient has been discharged home after ventricular assist device implant and underwent successful heart transplant after 111 days of support without any complications including any thromboembolic events. This new transatrial left atrial cannulation technique can be an alternative approach for ventricular assist device cannulation in hypertrophic cardiomyopathy. It can be safely performed with the HeartWare ventricular assist device.
Journal of the American College of Cardiology | 2017
Vamsi Yarlagadda; Katsuhide Maeda; Yulin Zhang; S. Chen; J.C. Dykes; Mary Alice Gowen; P. Shuttleworth; J. Murray; Andrew Y. Shin; Olaf Reinhartz; David N. Rosenthal; Doff B. McElhinney; Christopher S. Almond
Journal of Heart and Lung Transplantation | 2016
J.C. Dykes; David M. Peng; Christopher S. Almond; L.M. Barkoff; Beth D. Kaufman; Daniel Bernstein; David N. Rosenthal; Seth A. Hollander
Journal of Heart and Lung Transplantation | 2018
J.C. Dykes; M.S. Bleiweis; Katsuhide Maeda; S. Chen; David N. Rosenthal; C. Tjossem; J. Murray; Christopher S. Almond
Journal of Heart and Lung Transplantation | 2018
L.M. Barkoff; Katsuhide Maeda; David N. Rosenthal; Yulin Zhang; Seth A. Hollander; J.C. Dykes; S. Chen; Nancy McDonald; S.J. Wilkens; Christopher S. Almond
Journal of Heart and Lung Transplantation | 2018
S.J. Wilkens; Christopher S. Almond; S. Chen; Scott R. Ceresnak; J. Murray; J.C. Dykes; Kara S. Motonaga; David N. Rosenthal; C. Tjossem; Anne M. Dubin
Journal of Heart and Lung Transplantation | 2018
C. Knoll; J.C. Dykes; R. Shetty; E. Liu; David N. Rosenthal; S. Chen; Doff B. McElhinney; Christopher S. Almond