J.Ch. Piette

Hypertension artérielle maligne par lésion de l'artère rénale au cours du syndrome des antiphospholipides associé au lupus

We report on 5 patients with antiphospholipid syndrome secondary to systemic lupus erythematosus, that developed malignant systemic hypertension and renal insufficiency due to unilateral renal artery lesion such as stenosis (n = 3) or thrombosis (n = 2), in absence of overt diffuse lupus nephritis.

Atteinte cardiaque au cours du syndrome hyperéosinophilique: l'association avec les anticorps anticardiolipine est-elle forfuite?

Hypereosinophilic syndrom (HES) with cardiac involvement and anticardiolipin antibodies (ACL). Report of 4 cases. The relation between ACL and HES is discussed.

Immunoglobulines intra-veineuses de première intention dans les polymyosites et dermatomyosites de l'adulte

Eleven patients with active recent inflammatory myopathy (6DM/5PM) were treated by IVIG in first choice. Significant clinical improvement was noted in 3 out of the 11 patients. IVIG therapy in first intention can be discussed especially in patients with contra-indication of steroids.

Anticorps anti-phospholipides et anti-β2 glycoprotéine dans le syndrome de Sneddon. À propos de 16 cas

16 patients with Sneddons syndrome (SNS) were prospectively studied. All patients had at least one of the following antibodies: lupus anticoagulant (5), anticardiolipin (7), mixed anionic phospholipids (7), phosphatidyl ethanolamine (1) and anti-β2 glycoprotein I antibodies (11). SNS is closely related to the antiphospholipid syndrome.

Activité procoagulante des cellules endothéliales humaines en présence d'anticorps antiphospholipides

We studied endothelial cell (EC) procoagulant activity (PCA) after their incubation with antiphospholipid antibodies (aPL). PCA was increased when EC were incubated with serum containing anionic aPL such as anticardiolipin, while it was not modified after incubation with serum containing zwitterionic aPL. Mechanisms of aPL induced thrombosis are dependent upon the charge of phospholipids against which they are directed.

Valvulopathies opérées au cours du lupus et du syndrome des antiphospholipides: aspects cliniques et évolutifs à propos de sept observations

We report seven cases of valvular heart replacement in patients with systemic lupus erythematosus or primary antiphospholipid syndrome. All patients were alive with a mean follow-up of 60 months; the post-operative period was uncomplicated in 5 patients; mediastinum infection was observed in two patients and hemorrhagic complications in one chronically hemodialyzed patient.

Granulomatose de Wegener à évolution prolongée. Possible association avec une polychondrite atrophiante

We report a case of prolonged Wegeners granulomatosis a lasting more than 30 years. Associated symptoms consistent with a relapsing polychondritis recall possible overlap between both diseases.

Hémorragies filiformes sous-unguéales multiples et syndrome des antiphospholipides

We report 5 patients with multiple subungual splinter haemorrhages (MSSH) and antiphospholipid syndrome (APS). APS was secondary to systemic lupus in three, to distomatosis in one and was considered as « primaryin one. MSSH are a new feature of APS but further studies are needed to determine its significance in APS and its prevalence in other diseases.

Les lymphocytes T sont « naïfsdans le syndrome primaire des antiphospholipides

T lymphocyte subsets were studied in the peripheral blood from patients with primary antiphospholipid syndrome (PAPS) by double-labelling immunofluorescence. The proportion of CD4 + CD45 RA + cells was higher (p

Perforation de la cloison nasale: un nouveau symptôme associé aux anticorps anti-phospholipides et au syndrome de Sneddon

Nasal septum perforation (NSP) is a rare complication of lupus. We report on NSP in 3 patients with antiphospholipid (APL) antibodies associated (n = 2) or not (n = 1) with lupus, and in one patient with Sneddons syndrome whose serum was negative for APL antibodies but positive for anti-s2 glycoprotein 1 antibodies. NSP could be caused by a thrombotic phenomenon and then belong to APL syndrome.