J. Choiński

Electromagnetic structure of 98Mo

Abstract The nucleus 98 Mo was multiply Coulomb excited using 20 Ne, 84 Kr and 136 Xe beams. Eighteen E2 and M1 reduced matrix elements connecting 7 low-lying levels have been determined using the least-squares code GOSIA. The results are compared with the predictions of an extended version of the IBM1 model. The quadrupole sum rules approach was used to determine the shape parameters in two 0 + (ground and first excited) states. The rotational invariants 〈Q 2 〉 and 〈 cos 3δ〉 obtained show the shape coexistence in 98 Mo nucleus: the triaxial ground state and the prolate first excited state.

Production of medical Sc radioisotopes with an alpha particle beam

The internal α-particle beam of the Warsaw Heavy Ion Cyclotron was used to produce research quantities of the medically interesting Sc radioisotopes from natural Ca and K and isotopically enriched 42Ca targets. The targets were made of metallic calcium, calcium carbonate and potassium chloride. New data on the production yields and impurities generated during the target irradiations are presented for the positron emitters 43Sc, 44gSc and 44mSc. The different paths for the production of the long lived 44mSc/44gSc in vivo generator, proposed by the ARRONAX team, using proton and deuteron beams as well as alpha-particle beams are discussed. Due to the larger angular momentum transfer in the formation of the compound nucleus in the case of the alpha particle induced reactions, the isomeric ratio of 44mSc/44gSc at a bombarding energy of 29MeV is five times larger than previously determined for a deuteron beam and twenty times larger than for proton induced reactions on enriched CaCO3 targets. Therefore, formation of this generator via the alpha-particle route seems a very attractive way to form these isotopes. The experimental data presented here are compared with theoretical predictions made using the EMPIRE evaporation code. Reasonable agreement is generally observed.

Biological effectiveness of 12 C and 20 Ne ions with very high LET

Purpose: To determine the relationship between the relative biological effectiveness (RBE) for cell inactivation and linear energy transfer (LET) in the Bragg peak region of 12C and 20Ne ions. Materials and methods: Chinese hamster ovary (CHO-K1) cells were exposed to high LET 12C (33.2 MeV, 20.3 MeV, 9.1 MeV at cell entrance) and 20Ne ions (56.2 MeV, 34.7 MeV, 15 MeV at cell entrance) and to low LET x-rays. Technical details of the irradiation facility are presented which is based on the Monte Carlo simulation of the lateral spread of heavy ions as a result of the multiscattering small-angle process in physical conditions of the experimental set-up. Results: RBE has been measured for LET values close to the Bragg peak maximum, i.e., 440–830 keV/μm for 12C and for 1020–1600 keV/μm for 20Ne ions. RBE values at several levels of survival were estimated and were found to decrease with increasing LET. The inactivation cross sections were calculated from the final slope of dose-response curves and were found to increase with increasing LET. Conclusions: The RBE decreases with increasing LET in the range between 440 and 1600 keV/μm for the two types of radiations forming a single line when plotted together, pointing towards LET as the single determinant of RBE. The inactivation cross section describing the killing efficiency of a single particle at the end of particle range comes close to the size of the cell nucleus.

Cell survival and chromosomal aberrations in CHO-K1 cells irradiated by carbon ions

Chinese hamster ovary CHO-K1 cells were exposed to high LET (12)C-beam (LET: 830 keV/microm) in the dose range of 0-6 Gy and to (60)Co irradiation and the RBE value was obtained. Effects of (12)C-beam exposure on cell survival and chromosomal aberrations were calculated. The chromosomal aberration data were fitted with linear equation. The distribution of aberration in cells was examined with a standard u-test and used to evaluate the data according to Poisson probabilities. The variance to the mean ratio sigma(2)/Y and the dispersion index (u) were determined. Overdispersion was significant (p<0.05) when the value of u exceeded 1.96.

Manufacturing and characterization of molybdenum pellets used as targets for 99mTc production in cyclotron

The method of 100Mo metallic target preparation for production of 99mTc by proton irradiation in 100Mo(p,2n)99mTc reaction was demonstrated. For this purpose, pressing of molybdenum powder into pellets and their subsequent sintering in reductive atmosphere were applied. The influence of parameters such as molybdenum mass and time of both pressing and sintering on the 100Mo target durability was investigated. Under the optimized conditions, 100Mo metallic pellet targets with density of 9.95±0.06g/cm3 were obtained. Morphology and structure of pressed pellets before and after sintering were studied by using standard optical microscope and Scanning Electron Microscope (SEM). Nanoindentation technique was used to investigate the mechanical properties such as nanohardness and Young modulus. Prepared 100Mo pellets were successfully irradiated with protons and 99mTc was efficiently isolated.

Targets for production of the medical radioisotopes with alpha and proton or deuteron beams

The research quantities of some medical radioisotopes were produced in reactions induced by 32 MeV internal alpha beam (211At, Sc isotopes), 16 MeV and 28 MeV proton beams (Sc isotopes) and 8 MeV deuteron beam (Sc isotopes).The frame-less targets used for irradiation with internal alpha beam were prepared from elemental (Bi for 211At) and compound (CaCO3 for Sc radioisotopes) materials. The CaCO3 powder targets were also used for production of Sc radioisotopes with proton or deuteron external beams. Methods developed for preparation of the targets suitable for the irradiating beam type are described in this work.The research quantities of some medical radioisotopes were produced in reactions induced by 32 MeV internal alpha beam (211At, Sc isotopes), 16 MeV and 28 MeV proton beams (Sc isotopes) and 8 MeV deuteron beam (Sc isotopes).The frame-less targets used for irradiation with internal alpha beam were prepared from elemental (Bi for 211At) and compound (CaCO3 for Sc radioisotopes) materials. The CaCO3 powder targets were also used for production of Sc radioisotopes with proton or deuteron external beams. Methods developed for preparation of the targets suitable for the irradiating beam type are described in this work.

Separation of 44Sc from Natural Calcium Carbonate Targets for Synthesis of 44Sc-DOTATATE

The rapid increase in applications of scandium isotopes in nuclear medicine requires new efficient production routes for these radioisotopes. Recently, irradiations of calcium in cyclotrons by α, deuteron, and proton beams have been used. Therefore, effective post-irradiation separation and preconcentration of the radioactive scandium from the calcium matrix are important to obtain the pure final product in a relatively small volume. Nobias resin was used as a sorbent for effective separation of 44Sc from calcium targets. Separation was performed at pH 3 using a column containing 10 mg of resin. Scandium was eluted with 100 μL of 2 mol L−1 HCl. Particular attention was paid to the reduction of calcium concentration, presence of metallic impurities, robustness and simple automation. 44Sc was separated with 94.9 ± 2.8% yield, with results in the range of 91.7–99.0%. Purity of the eluate was confirmed with ICP-OES determination of metallic impurities and >99% chelation efficiency with DOTATATE, followed by >36 h radiochemical stability of the complex. A wide range of optimal conditions and robustness to target variability and suspended matter facilitates the proposed method in automatic systems for scandium isotope separation and synthesis of scandium-labeled radiopharmaceuticals.

Production of Sc medical radioisotopes with proton and deuteron beams

Proton and deuteron beams (15.3 and 6.8 MeV, respectively) extracted from the PETtrace medical cyclotron at the Radiopharmaceuticals Production and Research Centre in the University of Warsaw, Heavy Ion Laboratory, 28 MeV protons from the C30 cyclotron at the National Centre for Nuclear Research, Świerk, near Warsaw and 33 MeV protons from the ARRONAX accelerator, Nantes were used to produce and investigate the medically interesting Sc radioisotopes. Both natural and isotopically enriched CaCO3 and TiO2 targets were used (42Ca, 43Ca, 44Ca, 48Ca, 48Ti). The production efficiency and isotopic purity were determined and are reported here for the highest commercially available enrichments of the target material. The Thick Target Yield, Activities at the End of Bombardment (EOB) and the relative activities of produced impurities at EOB are reported for 43Sc, 44gSc, 44mSc and 47Sc produced with particle energies below 33 MeV.

Production efficiency and radioisotopic purity of 99mTc formed using the (p,2n) reaction on a highly enriched 100Mo target

The 99mTc isomer was produced using the (p, 2n) reaction on highly enriched 100Mo samples. The Thick Target Yields were determined in the energy range from 16 MeV to 26 MeV and compared with the values calculated using the most recent cross-section recommendations from the literature. The generated impurities were also determined. It was shown that for 99.815 ± 0.010% enriched samples, only reactions induced on 100Mo are of importance. The ratio of the number of atoms of 99mTc to all produced Tc nuclei was studied as a function of irradiation time and bombarding energy.

Comparison of the {sup 7}Li({sup 18}O,{sup 17}N){sup 8}Be and {sup 18}O(d,{sup 3}He){sup 17}N reactions

New angular distributions for the {sup 7}Li({sup 18}O,{sup 17}N){sup 8}Be reaction at an energy of E{sub lab}({sup 18}O)=114 MeV for the ground states of {sup 8}Be and {sup 17}N and the excited states of {sup 17}N were measured. These data and {sup 18}O(d,{sup 3}He){sup 17}N reaction data taken at E{sub d}=52 MeV were analyzed within the coupled-reaction-channels method using {sup 7}Li+{sup 18}O and {sup 18}O + d optical potentials deduced from previous elastic and inelastic scattering results. Shell-model spectroscopic amplitudes were used in the analysis. Both reactions are dominated by single proton transfer. Calculations show that heavy-ion reactions of the type studied in this work can be used to identify final-state spins when measurements are carried to small angles.