J. H. Boss

Naturally occurring antibodies to bovine serum albumin in the parotid saliva of rats.

Abstract Antibodies to bovine serum albumin were detected in the parotid saliva of untreated rats and rats, the glands of which had been repeatedly instilled with saline via their ducts. The incidence and titre of antibodies were higher after ductal instillation of saline. It is suggested that local sensitization occurs, probably due to bovine milk components which are present in the food pellets, gaining access to immunocompetent cells within the gland. No antibodies to bovine serum albumin were found in the serum.

Experimental arthritis in the rabbit induced by group a streptococcal products

Intraartikuläre Injektion von Streptolysin-S-freien extrazellulären Produkten der Streptokokken Gruppe A verursacht eine zunächst akute, in der Folge aber subkutane Synovitis. Die Veränderungen gleichen denjenigen nach Injektion von Streptolollensonikaten, so dass angenommen wird, ausser Streptolysin S bedingen auch andere streptokokkale Faktoren eine Arthritis.

Urinary excretion of placenta specific antigens in rats with normal and pathological pregnancy.

Abstract Organ specific antisera were used to search for placental antigens in the urine of rats. The urine of male and virgin female rats was devoid of placental antigens. The antigens were detected in three of 150 urine specimens obtained from 30 presumably normal pregnant rats. When nephrotoxic serum or endotoxin were administered in order to intervene in the normal course of gestation, placental antigens were found in urine samples obtained during 30 of 40, and eight of 32 pregnancies, respectively. Demonstration of placenta specific antigens in the urine may be of aid in the diagnosis of pathological processes involving the placenta.

Reappearance of α-Fetoprotein in Spontaneous Hepatitis in the Rat

Reappearance of AFP was demonstrated in a single rat out of a large control population. At autopsy, this DOCA-hypertensive rat was found to have a form of hepatitis associated with proliferative activity, i.e., cellular unrest, mitotic figures and oval cell hyperplasia. It is submitted that increased AFP synthesis in this animal with spontaneous hepatitis is causally related to hepatocellular regeneration.

Excretion ofα-M-fetoprotein in the urine of rats

Nachweis von α-M-Fetoprotein im Harn trächtiger Ratten, die an Masugi-Nephritis litten. Da dieses hochmolekulare Eiweiss im Harn normaler trächtiger Tiere nicht vorkommt, beweist sein Auftreten bei den Nephritis-Ratten eine nicht selektive Proteinurie.

Proteinuria in the rat: A comparison of tissue components in the voided and renal pelvic urine

Es wird gezeigt, dass bei gesunden männlichen Ratten nur Urin, der die unteren Harnwege passiert, Bestandteile der Geschlechtsdrüsen enthält. Somit ist die normale Proteinurie zum Teil auf die Ausscheidung extrarenaler Gewebskomponenten zurück-zuführen.

Autograft rejection, temporary transplantation of autografts to allogeneic and xenogeneic hosts within and without diffusion chambers

Des autogreffes transférées à des hôtes allogéniques, sensibilisés auparavant pendant 24 h, ont été rejetées après une retransplantation orthotopique au donneur original. Les greffes qui ont été transférées dans des chambres millipores ont été acceptées. Des autogreffes qui ont été transférées à des animaux xénogéniques possesseurs ou non de chambres à diffusion ont été rejetées dans la plupart des cas.