J.H Helderman

Renal Function in Primary Liver Transplant Recipients Receiving Neoral (Cyclosporine) Versus Prograf (Tacrolimus)

Immunosuppressive efficacy of Neoral and Prograf following primary hepatic transplantation was comparable. Incidence of rejection episodes, infectious complications, hypertension, and postoperative diabetes mellitus was comparable. Although clinical use of both immunosuppressants was associated with early compromise in renal function, no progressive renal dysfunction was observed.

Impact of sandimmune, neoral, and prograf on rejection incidence and renal function in primary liver transplant recipients

Following primary liver transplantation, immunosuppressive efficacy of Neoral and Prograf was similar and superior to that of Sandimmune. Rejection incidence was statistically increased with Sandimmune therapy. Incidence of hypertension, posttransplant diabetes mellitus, and infectious complications was not statistically different. Although early compromise in renal function was associated with Sandimmune, Neoral, and Prograf immunosuppression, no progressive renal dysfunction was identified.

Contemporary dialysis: as good as transplantation?

Kidney transplantation is well known to increase survival and improve quality of life over conventional dialysis therapies. But are contemporary, intensive dialysis therapies, such as nocturnal home hemodialysis, associated with outcomes as good as those obtained with deceased donor transplantation?