J. IJzermans

Body composition and outcome in patients undergoing resection of colorectal liver metastases.

Recent evidence suggests that depletion of skeletal muscle mass (sarcopenia) and an increased amount of intra‐abdominal fat (central obesity) influence cancer statistics. This study investigated the impact of sarcopenia and central obesity on survival in patients undergoing liver resection for colorectal liver metastases (CLM).

Stereotactic body radiation therapy for colorectal liver metastases

Stereotactic body radiation therapy (SBRT) is a treatment option for colorectal liver metastases. Local control, patient survival and toxicity were assessed in an experience of SBRT for colorectal liver metastases.

Trends in incidence, treatment and survival of patients with stage IV colorectal cancer: a population‐based series

Aim  The incidence, patterns of care and survival were determined in patients with stage IV colorectal cancer (CRC) in a population‐based series.

Systematic review of haemorrhage and rupture of hepatocellular adenomas.

Although benign in itself, hepatocellular adenoma (HCA) can be complicated by hormone‐induced growth, and subsequent haemorrhage and rupture. The exact risk of haemorrhage and rupture is not known. This systematic review of the literature was carried out with the aim of estimating the risk of haemorrhage and rupture in HCA.

Optimizing the outcome of surgery in patients with rectal cancer and synchronous liver metastases

This study evaluated the outcome of patients treated for rectal cancer and synchronous hepatic metastases in the era of effective induction radiotherapy and chemotherapy.

Case-orientated approach to the management of hepatocellular adenoma

Treatment of suspected hepatocellular adenoma (HA) remains controversial. The aim of this study was to evaluate the management of HA at a time when magnetic resonance imaging (MRI) and computed tomography (CT) are highly sensitive methods for diagnosing HA.

Systematic review of sarcopenia in patients operated on for gastrointestinal and hepatopancreatobiliary malignancies

Preoperative risk assessment in cancer surgery is of importance to improve treatment and outcome. The aim of this study was to assess the impact of CT‐assessed sarcopenia on short‐ and long‐term outcomes in patients undergoing surgical resection of gastrointestinal and hepatopancreatobiliary malignancies.

Heat-resistant cylindrical diffuser for interstitial laser coagulation: comparison with the bare-tip fiber in a porcine liver model.

Interstitial laser coagulation is an experimental treatment to eliminate solid tumors such as hepatic metastases. The pattern of light emission from the fiber tip is probably an important factor in determining the size and shape of a lesion. A heat‐resistant cylindrical light diffusing tip of 2 cm length was developed for this application. We performed an in vitro study to compare this diffusing‐tip with a bare‐tip fiber.

Critical temperature and heating time for coagulation damage: implications for interstitial laser coagulation (ILC) of tumors.

Interstitial laser coagulation (ILC) is a method of local tissue destruction for solid tumors such as irresectable hepatic metastases from colorectal cancer. With the availability of new magnetic resonance (MR) techniques, which allow real time tissue temperature mapping, it is essential to know the critical temperature and exposure times leading to cell death.

Metabolic activity and DNA integrity in human hepatic metastases after interstitial laser coagulation (ILC).

For investigations into interstitial laser coagulation (ILC) of solid tumors, tissue whitening is used as a parameter for the extent of coagulation. This obvious demarcation is associated with global thermal denaturation, but it is not clear whether this finding is a good indicator of the exact outer boundary of the lethal tissue effect.