J. J. Arias León

Simultaneous determination of amitriptyline, imipramine and perphenazine in pharmaceutical preparations and blood serum by multi-wavelength spectrophotometry

Abstract Several methods were developed for the simultaneous determination of the binary mixtures amitriptyline—imipramine (1.00–10 μg ml−1), amitriptyline—perphenazine (1.00–30.00 and 1.00–8.00 μg ml−1) and imipramine—perphenazine (1.00–30.00 and 1.00–8.00 μg ml−1) and the ternary mixture amitriptyline—perphenazine—imipramine using a diode-array spectrophotometer and a multi-component analysis program. The methods were applied to the determination of the components of synthetic perphenazine—imipramine mixtures, real amitriptyline—imipramine and amitriptyline—imipramine—perphenazine mixtures in blood serum and real amitriptyline—perphenazine mixtures in pharmaceutical preparations.

Simultaneous determination of imipramine and amitryptiline by derivative spectrophotometry

Abstract Three methods are proposed for the simultaneous determination of imipramine and amitryptiline by derivative spectrophotometry, one of them using both first- and second-derivative spectra, and the others using the first- and second-derivative spectra, respectively, obtained from a “diode array” spectrophotometer. The methods allow the determination of 0.62–10.14 μg ml−1 of imipramine, and 0.63–10.04 μg ml−1 of amitryptiline, and have been applied to their determination in blood serum.

Quantity of K, Ca, Na, Mg, Fe, Cu, Pb, Zn and ashes in DOC Tacoronte-Acentejo (Canary Islands, Spain) musts and wines

This study determines ash, K, Ca, Na, Mg, Fe, Cu, Pb, and Zn content in musts and wines of the DOC Tacoronte-Acentejo (Tenerife, Canary Islands) from two consecutive harvests. Samples were treated with HNO3 and H2O2. Na and K were determined by flame photometry and the remaining metals by air/acetilene flame atomic absorption spectrophotometry. Significant differences were observed in Na, Ca and Mg contents between both harvests, possibly due to climate conditions.This study determines ash, K, Ca, Na, Mg, Fe, Cu, Pb, and Zn content in musts and wines of the DOC Tacoronte-Acentejo (Tenerife, Canary Islands) from two consecutive harvests. Samples were treated with HNO3 and H2O2. Na and K were determined by flame photometry and the remaining metals by air/acetilene flame atomic absorption spectrophotometry. Significant differences were observed in Na, Ca and Mg contents between both harvests, possibly due to climate conditions.

Use of an azo derivative immobilized on an anionic resin for the determination of aluminium in water and dialysis fluids

Abstract We studied the retention of aluminium on Chromotrope-2R immobilized on Amberlite IRA-400 resin with a view to the subsequent atomic spectrometric determination of the metal. The determinative method thus developed allows the determination of aluminium in water and dialysis fluids over the concentration ranges 0.92–19.46 and 0.37–0.74 μmol/l, respectively.