J.J. Bustillos-Guzmán
Instituto Politécnico Nacional
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Featured researches published by J.J. Bustillos-Guzmán.
Toxins | 2016
Lorena M. Durán-Riveroll; Allan Cembella; Christine J. Band-Schmidt; J.J. Bustillos-Guzmán; José Correa-Basurto
Saxitoxin (STX) and its analogs are paralytic alkaloid neurotoxins that block the voltage-gated sodium channel pore (Nav), impeding passage of Na+ ions into the intracellular space, and thereby preventing the action potential in the peripheral nervous system and skeletal muscle. The marine dinoflagellate Gymnodinium catenatum produces an array of such toxins, including the recently discovered benzoyl analogs, for which the mammalian toxicities are essentially unknown. We subjected STX and its analogs to a theoretical docking simulation based upon two alternative tri-dimensional models of the Nav1.4 to find a relationship between the binding properties and the known mammalian toxicity of selected STX analogs. We inferred hypothetical toxicities for the benzoyl analogs from the modeled values. We demonstrate that these toxins exhibit different binding modes with similar free binding energies and that these alternative binding modes are equally probable. We propose that the principal binding that governs ligand recognition is mediated by electrostatic interactions. Our simulation constitutes the first in silico modeling study on benzoyl-type paralytic toxins and provides an approach towards a better understanding of the mode of action of STX and its analogs.
Hidrobiologica | 2015
D.J. López-Cortés; E.J. Nuñez-Vázquez; Christine J. Band-Schmidt; Ismael Gárate-Lizárraga; Francisco Eduardo Hernández-Sandoval; J.J. Bustillos-Guzmán
Hidrobiologica | 2015
D.J. López-Cortés; E.J. Nuñez-Vázquez; Christine J. Band-Schmidt; Ismael Gárate-Lizárraga; Francisco Eduardo Hernández-Sandoval; J.J. Bustillos-Guzmán
Hidrobiologica | 2015
D.J. López-Cortés; E.J. Nuñez-Vázquez; Christine Johanna Band Schmidt; Ismael Gárate-Lizárraga; Franciso E. Hernández-Sandoval; J.J. Bustillos-Guzmán
XVII Reunión Nacional de la Sociedad Mexicana de Planctología y X International Meeting of the Mexican Society of Planktology | 2012
Lorena M. Durán-Riveroll; Christine Johanna Band Schmidt; J.J. Bustillos-Guzmán
XVII Reunión Nacional de la Sociedad Mexicana de Planctología y X International Meeting of the Mexican Society of Planktology | 2012
Fernando E. Hernández-Sandoval; Christine Johanna Band Schmidt; E.J. Nuñez-Vázquez; D.J. López-Cortés; J.J. Bustillos-Guzmán; M. Félix-Virgen
XVII Reunión Nacional de la Sociedad Mexicana de Planctología y X International Meeting of the Mexican Society of Planktology | 2012
Christine Johanna Band Schmidt; Aida Martinez Lopez; J.J. Bustillos-Guzmán; Laura Carreón-Palau; Lourdes Morquecho; N.O. Olguín-Monroy; T. Zenteno-Savín; F.H. Hernández-Sandoval; C. Tomas
1er Congreso Nacional de la Sociedad Mexicana para el Estudio de los Florecimientos Algales Nocivos (SOMEFAN, A. C.) | 2011
Christine Johanna Band Schmidt; J.J. Bustillos-Guzmán; D.J. López-Cortés; E.J. Nuñez-Vázquez; Francisco Eduardo Hernández-Sandoval
1er Congreso Nacional de la Sociedad Mexicana para el Estudio de los Florecimientos Algales Nocivos (SOMEFAN, A. C.) | 2011
E.J. Nuñez-Vázquez; A. Cordero-Tapia; J.L. Ochoa; J.J. Bustillos-Guzmán; D.J. López-Cortés; Christine Johanna Band Schmidt; Francisco Eduardo Hernández-Sandoval; M. Ramírez-Orozco; D. Ceseña Arce; C. Ramírez Camarena
1er Congreso Nacional de la Sociedad Mexicana para el Estudio de los Florecimientos Algales Nocivos (SOMEFAN, A. C.) | 2011
J.J. Bustillos-Guzmán; Christine Johanna Band Schmidt; D.J. López-Cortés; E.J. Nuñez-Vázquez; Francisco Eduardo Hernández-Sandoval