J.J. Huang

Safflower yellow inhibits the inflammatory response and regulates microglial polarization in LPS-stimulated bv2 cells

myositis (2) indirect effects due to metabolic complications resulting in encephalopathy and cerebrovascular complications due to thrombocytopenia and platelet dysfunction and (3) postinfectious immunemediated acute disseminated encephalomyelitis, Guillain Barre syndrome and optic neuritis. Material and methods: This was a descriptive cross sectional study including seropositive patients diagnosed with Dengue fever (DF), Dengue with warning signs and Severe Dengue with neurological manifestations presenting to Medicine Department of LLR Hospital, Kanpur. Results: 10 (2.6%) patients had neurological manifestations out of 383 seropositive patients. Out of ten, nine patients were male and only one patient was female. Among them 10% patients come under category of classical dengue fever, 10% patients suffered from dengue with warning signs and 80% with severe dengue .4 patients had encephalopathy,3 other patients had encephalitis, 2 patients presented with single episode of symptomatic generalized seizure and 1 patient presented as having an intra cranial hemorrhage. Conclusions: Neurological manifestations of dengue are manifold and it is necessary to consider dengue as a cause for the above neurological presentations in endemic zones of the disease.