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Synthetic Communications | 1978

Oxygenated γ-Butyrolactones

T. A. Eggelte; J. J. J. De Boer; H. De Koning; H. O. Huisman

Abstract In connection with other studies we needed 2-(carboxymethyl)-3-hydroxycyclohexanone lactone 3a. We reasoned that 3a might be obtained from 2-(carboxymethyl)-1,3-cyclohexanedione la via conversion into enol lactone 2a followed by catalytic hydrogenation. Survey of the literature revealed that this approach had already been attempted by Rosenmund et al.2 While their reaction sequence was successful in case of the dimedone derivative lb, which was converted into 2b and 3b, the synthesis failed for la because lactonization with acetyl chloride resulted in the formation of a complex mixture of acylated compounds, which could not be characterized with certainty.


Recueil des Travaux Chimiques des Pays-Bas | 2010

Cationic heterocyclisation One-step synthesis of condensed heterocyclics†

J.B.P.A. Wijnberg; J. J. J. De Boer; W.N. Speckamp


Tetrahedron Letters | 1975

ω-Carbinollactams in regioselective olefinsynthesis

J. J. J. De Boer; W.N. Speckamp


Recueil des Travaux Chimiques des Pays-Bas | 2010

Carbon‐carbon bond forming reactions of ω‐oxylactams in acid and neutral medium

W.N. Speckamp; J. J. J. De Boer


Tetrahedron Letters | 1974

Cationic heterocyclization One step synthesis of condensed heterocyclics

J.B.P.A. Wijnberg; W.N. Speckamp; J. J. J. De Boer


Recueil des Travaux Chimiques des Pays-Bas | 2010

Base-catalyzed carbon-carbon bond formation reactions of ω-hydroxylactams

W.N. Speckamp; J. J. J. De Boer


ChemInform | 1984

BASE-CATALYZED CARBON-CARBON BOND FORMATION REACTIONS OF Ω-HYDROXY LACTAMS

W.N. Speckamp; J. J. J. De Boer


ChemInform | 1984

CARBON-CARBON BOND FORMING REACTIONS OF Ω-HYDROXY LACTAMS IN ACID AND NEUTRAL MEDIUM

W.N. Speckamp; J. J. J. De Boer


ChemInform | 1983

TWO CLONIDINE-LIKE COMPOUNDS WITH SUBSTITUENTS AT THE 2-, 3-, AND 6-POSITION OF THE PHENYL RING POSSESSING PRONOUNCED HYPOTENSIVE POTENCIES

P. B. M. W. M. Timmermans; A. de Jonge; P. A. van Zwieten; J. J. J. De Boer; N. W. Speckamp


ChemInform | 1981

REDUCTIVE METHYLATION OF Ω-CARBINOLLACTAMS VIA ANOMALOUS WITTIG REACTION

J. J. J. De Boer; W.N. Speckamp

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H. De Koning

University of Amsterdam

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A. de Jonge

University of Amsterdam

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I. E. Maxwell

University of Canterbury

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