J.K. Cooper | Researchain

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Xenobiotica | 1979

Metabolic O-demethylation of 3,4-dimethoxy-amphetamine in vivo in dog and monkey

K.K. Midha; K. Bailey; J.K. Cooper; J. W. Hubbard

1. The disposition of the hallucinogen 3,4-dimethoxyamphetamine in vivo was examined in dogs and monkeys. 2. O-Demethylation is important since 3-O-methyl-alpha-methyldopamine (3-methoxy-alpha-methyltyramine) was found in the urine of both species, and traces of alpha-methyldopamine were found in the urine of dogs. 3. Also found in the urine of dogs were 1-(3,4-dihydroxyphenyl)propan-2-one and 3,4-dihydroxybenzoic acid, which are side-chain modified metabolites of alpha-methyldopamine. 4. 1-(3-Methoxy-4-hydroxyphenyl)propan-2-one, a side-chain modified metabolite of 3-O-methyl-alpha-methyldopamine, was present in the urine of both dogs and monkeys. 5. The 3-O-demethylated isomers 4-O-methyldopamine and 1-(3-hydroxy-4-methoxyphenyl)propan-2-one were not detected.

Journal of Pharmaceutical Sciences | 1978

Radioimmunoassay for psychotropic drugs I: Synthesis and properties of haptens for chlorpromazine

J. W. Hubbard; K.K. Midha; I.J. McGilveray; J.K. Cooper

Journal of Pharmaceutical Sciences | 1978

Radioimmunoassay for Psychotropic Drugs II: Synthesis and Properties of Haptens for Tricyclic Antidepressants

J. W. Hubbard; K.K. Midha; J.K. Cooper; C. Charette

Journal of Pharmaceutical Sciences | 1979

Simple and Specific Electron-Capture GLC Assay for Plasma and Urine Ephedrine Concentrations following Single Doses

Kamal K. Midha; J.K. Cooper; I.J. McGilveray

Journal of Pharmaceutical Sciences | 1977

Identification of Urinary Catechol and Methylated Catechol Metabolites of Phenytoin in Humans, Monkeys, and Dogs by GLC and GLC-Mass Spectrometry

K.K. Midha; K.W. Hindmarsh; I.J. McGilveray; J.K. Cooper

Journal of Analytical Toxicology | 1979

Detection of Nanogram Levels of Various Ring-Substituted Phenylisopropylamines in Urine and Plasma by GLC-ECD

K.K. Midha; J.K. Cooper; D. Gagné; K. Bailey

Journal of Analytical Toxicology | 1980

Comparison of a New GLC-AFID Method With a GLC-MS Selected Ion Monitoring Technique and a Radioimmunoassay for the Determination of Plasma Concentrations of Imipramine and Desipramine

K.K. Midha; C. Charette; J.K. Cooper; I.J. McGilveray

Journal of Pharmaceutical Sciences | 1976

GLC Determination of Plasma Concentrations of Phenprocoumon

K.K. Midha; J.K. Cooper; I.J. McGilveray; J. W. Hubbard

Journal of Pharmaceutical Sciences | 1977

GLC Determinations of Plasma Acenocoumarol Levels

K.K. Midha; J.K. Cooper

Journal of Pharmaceutical Sciences | 1976

GLC identification and determination of 3,4-methylenedioxyamphetamine (MDA) from plasma and urine

K.K. Midha; I.J. McGilveray; S.P. Bhatnagar; J.K. Cooper

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