J. Manetta

Testosterone Is Significantly Reduced in Endurance Athletes without Impact on Bone Mineral Density

Aims: To compare the basal plasma reproductive hormonal profile in three groups of athletes involved in different training programs, and to define the relationship between androgen level and bone mineral density (BMD) in male athletes. Methods: Basal serum total testosterone (TT), free androgen index (FAI), sex hormone-binding globulin (SHBG), cortisol, cortisol to TT ratio, luteinizing hormone (LH), estrogen and BMD were evaluated in cyclists (CY; n = 11), triathletes (TR; n = 14) and swimmers (SW; n = 13) and compared with less active controls (n = 10). Results: TT and FAI levels were lower (p < 0.05) in CY and TR, whereas the ratio of cortisol to TT was increased in CY only (p < 0.05). No alteration in serum LH, SHBG, estrogen or cortisol concentration was observed. BMD was higher in the proximal femur in TR (p < 0.05). No BMD or hormonal differences were found in SW. Conclusion: Only the endurance training of CY and TR induced androgen deficiency without apparent alteration of BMD.

Effects of physical activities that induce moderate external loading on bone metabolism in male athletes

Sports characterized by little or moderate weight bearing or impact have a low osteogenic effect. However, the action of such sports on bone turnover remains unclear. The objective of this study was to determine the effect on bone remodelling of physical activities that induce moderate external loading on the skeleton. Thirty-eight male athletes aged 18–39 years (cyclists, n = 11; swimmers, n = 13; triathletes, n = 14) and 10 age-matched sedentary controls aged 22–35 years participated in the study. The study combined measurement of bone mineral density by dual-energy X-ray absorptiometry and bone turnover assessment from specific biochemical markers: serum bone-specific alkaline phosphatase, osteocalcin, urinary type I collagen C-telopeptide and calcium. Compared with the controls and swimmers, adjusted bone mineral density was higher (P < 0.05) in triathletes at the total proximal femur and lower limbs. No differences in bone mineral density were found between cyclists, swimmers and controls. Compared with controls, osteocalcin was higher (P < 0.05) in triathletes and swimmers and urinary type I collagen C-telopeptide was higher in swimmers only. Serum bone-specific alkaline phosphatase was lower (P < 0.05) in cyclists than in all other groups. In conclusion, an osteogenic effect was found only in triathletes, mainly at bone sites under high mechanical stress. Bone turnover differed in athletes compared with controls, suggesting that bone turnover may be sport-practice dependent. Despite some encouraging observations, it was not possible to show that changes in the bone remodelling process were sport-discipline dependent.

Fuel oxidation during exercise in middle-aged men: role of training and glucose disposal.

PURPOSE The purpose of this study was to test the hypothesis that carbohydrate (CHO) utilization in middle-aged trained men is increased during hard-intensity exercise and decreased during moderate-intensity exercise in comparison with age-matched sedentary men. We also investigated whether a relationship between CHO utilization and glucose disposal exists. METHODS Seven trained cyclists (Tr) and seven age-matched sedentary men (Sed) underwent an intravenous glucose tolerance test after an overnight fast (minimal model method) to determine their glucose disposal; they also performed two 1-h trials on a cycle ergometer below and above their individual ventilatory threshold (VT). Substrate oxidation was evaluated by indirect calorimetry. Hormonal responses were investigated during exercise. RESULTS Insulin sensitivity (SI) and glucose effectiveness (Sg) were significantly higher in the Tr group than in the Sed group (P < 0.001, P < 0.03). CHO oxidation was significantly higher in the Tr group than in the Sed group when exercise was performed above VT, whereas CHO oxidation was higher in the Sed group when exercise was performed below VT (P < 0.05). Epinephrine (Epi) response during hard-intensity exercise was higher in the Tr group than in the Sed group (P < 0.01). SI was negatively correlated to CHO oxidation in the Tr group (r = -0.743, P < 0.05). CONCLUSION Endurance training results in increased CHO utilization during hard-intensity exercise and reduced CHO oxidation during moderate-intensity exercise in middle-aged men. During hard-intensity exercise, the increased CHO utilization in middle-aged trained men is associated with a greater response in Epi and is inversely related with SI.

The effects of intensive training on insulin-like growth factor I (IGF-I) and IGF binding proteins 1 and 3 in competitive cyclists: relationships with glucose disposal.

Abstract The aim of the present study was to determine whether 4 months of intensified training would result in modified plasma insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein 1 (IGFBP-1) or IGFBP-3 in eight competitive cyclists and eight sedentary individuals and to define the relationships of these factors with glucose disposal. Insulin sensitivity and glucose effectiveness — that is, the fractional disappearance of glucose independent of any change in insulinaemia — were measured with the minimal model (mathematical analysis of frequently sampled intravenous glucose tolerance test). Both glucose effectiveness and insulin sensitivity were higher in the cyclists than in the sedentary individuals, but did not increase further with training. IGF-I was higher in the cyclists than in the sedentary group only after training (P<0.05). Plasma IGFBP-1 and IGFBP-3 increased after training (38 and 20%, respectively; P<0.05) in the cyclists and were higher than in the sedentary individuals (P<0.05). IGF-I was negatively correlated with insulin sensitivity before and after training (r=−0.66 and −0.67, respectively; P<0.05) and IGFBP-1 was negatively correlated with glucose effectiveness before and after training (r=−0.68 and −0.77, respectively; P<0.05). Our results show that strenuous endurance training improves the somatotrope axis (growth hormone—IGF) and that IGFBP-1 may be involved in glucose homeostasis, possibly by limiting the exercise-induced increase in glucose disposal, in competitive cyclists.

Serum levels of insulin-like growth factor-I (IGF-I), and IGF-binding proteins-1 and -3 in middle-aged and young athletes versus sedentary men: Relationship with glucose disposal

The goal of this study was to characterize the respective effects of aging and endurance training on serum insulin-like growth factor I (IGF-I), as well as IGF-binding proteins (IGFBP)-1 and -3 in relationship with glucose disposal. Thirty-two subjects (16 middle-aged men: 8 cyclists and 8 sedentary men; and 16 young men: 8 cyclists and 8 sedentary men) were compared in this study. Insulin sensitivity (SI) and glucose effectiveness (Sg) were assessed by the minimal model. Endurance training increased SI, Sg, and IGFBP-1 and -3 in both age groups (P<.05), but the older group showed a greater increase in SI and IGFBP-1 than the younger group (P<.05). IGF-I was increased only in the middle-aged trained men (P<.05). An effect of aging was found in the sedentary subjects, who presented lower IGF-I and SI (P<.05) when older. This effect disappeared with training since IGF-I and SI were nearly identical in young and middle-aged trained subjects. SI was correlated with IGFBP-1 (P<.01). These data suggest that (1) endurance training increases SI, Sg, and IGFBP-1 and -3 in men and, for SI and IGFBP-1, this increase becomes more pronounced with age; (2) endurance training may attenuate the aged-related decline in SI and IGF-I; and (3) IGFBP-1 may protect against the risk of hypoglycemia by counteracting the hypoglycemic effect of IGF-I in such situations of high SI.

Maximal oxygen uptake and power of lower limbs during a competitive season in triathletes

Background: In order to study the effect of a competitive triathlon season on maximal oxygen uptake (VO2max), aerobic power (AeP) and anaerobic performance (AnP) of the lower limbs, eight triathletes performed exercise tests after: (1) a pre‐competition period (Pre‐COMP) (2) a competitive period (COMP), and (3) a low (volume and intensity) training period (Post‐COMP). The tests were a vertical jump‐and‐reach test and an incremental exercise test on a cycle ergometer. Ventilatory data were collected every minute during the incremental test with an automated breath‐by‐breath system and the heart‐rate was monitored using a telemetric system.