J. Minguez

Endometrial blood flow mapping using transvaginal power Doppler sonography in women with postmenopausal bleeding and thickened endometrium

To evaluate the role of transvaginal power Doppler sonography to discriminate between benign and malignant endometrial conditions in women presenting with postmenopausal bleeding and thickened endometrium at baseline sonography.

Accuracy of transvaginal ultrasound for diagnosis of deep endometriosis in uterosacral ligaments, rectovaginal septum, vagina and bladder: systematic review and meta‐analysis

To review the diagnostic accuracy of transvaginal ultrasound (TVS) in the preoperative detection of endometriosis in the uterosacral ligaments (USL), rectovaginal septum (RVS), vagina and bladder in patients with clinical suspicion of deep infiltrating endometriosis (DIE).

Sonographic Features of Ovarian Cystadenofibromas Spectrum of Findings

To describe the sonographic characteristics of ovarian cystadenofibromas.

Three-dimensional power Doppler angiography in endometrial cancer: correlation with tumor characteristics

To assess the correlation between intratumoral vascularization using three‐dimensional power Doppler angiography (3D‐PDA) and several histological tumor characteristics in a series of patients with endometrial carcinoma.

Triage for surgical management of ovarian tumors in asymptomatic women: assessment of an ultrasound‐based scoring system

To prospectively evaluate an ultrasound‐based scoring system as a method for triaging asymptomatic women presenting with an adnexal mass for surgical treatment.

Transvaginal Color Doppler Sonography Versus Sonohysterography in the Diagnosis of Endometrial Polyps

Objective. To compare the diagnostic performance of transvaginal color Doppler sonography (TVCD) and sonohysterography (SHG) in the diagnosis of endometrial polyps. Methods. Fifty‐one women (mean age, 51 years; range, 27–75 years) with clinical or B‐mode sonographic suspicion of endometrial polyps were included in this prospective study. Transvaginal color Doppler sonography first and then SHG were performed in all patients. On TVCD, a polyp was suspected when a vascular pedicle penetrating the endometrium from the myometrium was identified. On SHG, a polyp was suspected when a focal polypoid lesion was seen within the endometrial cavity. All patients underwent hysteroscopy and endometrial biopsy, the findings of which were used as the criterion standard. Sensitivity and specificity for TVCD and SHG were calculated and compared by the McNemar test. Results. Hysteroscopy and endometrial biopsy findings were as follows: endometrial polyps, 41; endometrial hyperplasia, 3; cystic atrophy, 4; proliferative endometrium, 2; and endometritis, 1. Sensitivity and specificity for TVCD and SHG were 95% and 80% and 100% and 80%, respectively (McNemar test, P = .5) Conclusions. Transvaginal color Doppler sonography and SHG had similar performance for diagnosing endometrial polyps.

Transvaginal color Doppler ultrasonography and CA‐125 in suspicious adnexal masses

Objective: To compare diagnostic performance of color Doppler ultrasound and CA‐125 in suspicious adnexal masses on B‐mode sonography. Materials and methods: Data on 94 patients (mean age: 47.4 years, range: 17–79 years. Fifty‐two (55.3%) premenopausal and 42 (44.7%) postmenopausal women) managed in our institution because of a suspicious adnexal mass were reviewed. All patients were evaluated by transvaginal color Doppler ultrasonography (CD) and serum CA‐125 level determination prior to surgery. Definitive histopathological diagnosis was obtained in each case. Sonographic morphology evaluation was suspicious in all cases. CD was considered as suspicious when flow was detected and the lowest RI found was ≤0.45. CA‐125 cut‐off was ≥35 UI/ml. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for each method and compared. ROC analysis was performed for RI and CA‐125. Areas under curve (AUC) were calculated and compared. Results: Fifty‐six (59.6%) tumors were found to be malignant and 38 (40.4%) benign. Sensitivity, specificity, PPV and NPV for CD were 87.5% (95% CIs: 75.3–94.4), 84.2% (95% CIs: 68.7–94), 89.1% (95% CIs: 77.7–95.9) and 82.1% (95% CIs: 66.5–92.5), respectively. Sensitivity, specificity, PPV and NPV for CA‐125 were 83.9% (95% CIs: 71.7–92.4), 68.4% (95% CIs: 51.3–82.5), 79.7% (95% CIs: 66.2–89) and 74.3% (95% CIs: 56.7–87.5), respectively. Sensitivity, PPV and NPV were not statistically different. CD had higher specificity (P=0.01). AUC curve for Doppler (0.75) was significantly higher than for CA‐125 (0.61) (P=0.0002). Conclusions: Our results indicate that color Doppler ultrasound has a better diagnostic performance as compared with CA‐125, being significantly more specific.

Perinatal outcome and long-term follow-up of extremely low birth weight infants depending on the mode of delivery

Objective. To assess the effect of the mode of delivery (vaginal or cesarean section) on survival, morbidity, and long-term psychomotor development of extremely low birth weight (ELBW) infants. Methods. A longitudinal observational study including 138 ELBW infants (73 born by c-section and 65 vaginally) was conducted. We analyzed the survival and short-term morbidity. We also studied the long-term neurocognitive and motor development using the McCarthy Scales of Childrens Abilities (MSCA). Results. Mortality was significantly higher in newborns delivered vaginally (49.3%) than those delivered by c-section (23.1%). Newborns delivered vaginally had a higher incidence of retinopathy and peri-intraventricular hemorrhage (P-IVH). Children who died had lower gestational age at birth and lower birth weight. After multivariate analysis only birth weight, gestational age at birth and P-IVH were independently associated to mortality. Regarding the long-term evaluation (MSCA), we observed that children born by c-section had lower incidence of abnormal results. Conclusions. The mode of delivery does not affect survival. Cesarean section provides lower morbidity and better prognosis for neurodevelopment long-term outcome in ELBW infants

Transvaginal ultrasound for preoperative assessment of myometrial invasion in patients with endometrial cancer: a systematic review and meta-analysis.

To review the diagnostic accuracy of transvaginal ultrasound (TVS) in the preoperative detection of deep myometrial infiltration in patients with endometrial cancer, comparing subjective and objective methods.

Adding Cancer Antigen 125 Screening to Gray Scale Sonography for Predicting Specific Diagnosis of Benign Adnexal Masses in Premenopausal Women Is It Worthwhile

The purpose of this study was to assess whether a single determination of the serum cancer antigen 125 (CA‐125) level provides additional information to sonography for specific diagnosis of benign adnexal masses in premenopausal women.