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Featured researches published by J.N. Zanoni.


Autonomic Neuroscience: Basic and Clinical | 2003

Evaluation of the population of NADPH-diaphorase-stained and myosin-V myenteric neurons in the ileum of chronically streptozotocin-diabetic rats treated with ascorbic acid.

J.N. Zanoni; N.C Buttow; Roberto Barbosa Bazotte; M.H. Miranda Neto

We investigated the effect of the ascorbic acid on the nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d)-stained and myosin-V myenteric neurons in the ileum of chronically diabetic rats. The study was performed 4 months after inducing experimental diabetes with streptozotocin. Diabetic rats showed increased (p<0.05) glycaemia and glycated haemoglobin. Three groups were compared, i.e., nondiabetic rats, diabetic rats and diabetic rats treated with ascorbic acid. Myosin-V immunohistochemistry and NADPH-d histochemistry were employed. We investigated the areas of 500 cell bodies of myosin-V neurons and of 500 NADPH-d-stained neurons from all groups. The quantitative analysis was performed by using an area of 8.96 mm(2) from each ileum. The two groups of diabetic rats and diabetic rats treated with ascorbic acid showed reduction in the number and an increased area of the myosin-V-immunostained myenteric neurons. In addition, we observed increased relative proportion of NADPH-d-stained neurons in diabetic rats and diabetic rats treated with ascorbic acid. However, the area of these neurons in the diabetic rats group was larger than those evidenced in the nondiabetic rats and diabetic rats treated with ascorbic acid.


Anatomia Histologia Embryologia | 2005

Effects of Supplementation with Ascorbic Acid for a Period of 120 days on the Myosin-V and NADPHd Positive Myenteric Neurons of the Ileum of Rats

J.N. Zanoni; Priscila de Freitas; Reynaldo Pereira; M. A. Santos Pereira; M. H. Miranda Neto

We investigated the effect of ascorbic acid (AA) supplementation on the NADPH‐diaphorase (NADPHd) and myosin‐V myenteric neurons in the ileum of rats, after 4 months of treatment. Two groups were compared, i.e. controls rats (C) and AA‐treated rats (CA). Myosin‐V immunohistochemistry and NADPHd histochemistry were employed. We investigated the areas of 500 cell bodies of myosin‐V neurons and of 500 NADPHd stained neurons from all groups. The quantitative analysis was performed using an area of 8.96 mm2 from each ileum. There was an increase of 21.9% in the myosin‐V immunoreactive myenteric neurons (P > 0.05) and of 22.5% in the NADPHd in group CA when compared with C (P < 0.05). There were no significant differences when we compared the area of myosin‐V stained neurons between groups C and CA. However, we verified an area reduction of 7.5% in NADPHd neurons when comparing group C to group CA (P < 0.05).


Anatomia Histologia Embryologia | 2005

Morphoquantitative aspects of nitrergic myoenteric neurons from the stomach of diabetic rats supplemented with acetyl-L-carnitine.

Cept Fregonesi; S. L. Molinari; Amp Alves; Marli Aparecida Defani; J.N. Zanoni; Roberto Barbosa Bazotte; Mhd Neto

The NADPH‐diaphorase (NADPH‐d) positive myoenteric neurons from the body of the stomach of rats with streptozotocin‐induced diabetes with or without supplementation with acetyl‐L‐carnitine (ALC) were evaluated. At the age of 105 days the animals were divided into four groups: normoglycaemic (C), normoglycaemic supplemented with ALC (CC), diabetic (D) and diabetic supplemented with ALC (DC). The supplementation with ALC (200 mg/kg body weight/day) to groups CC and DC was made during 105 days. After this period the animals were killed and the stomach removed and subjected to the histochemical technique of NADPH‐d for the staining of the neurons of the myoenteric plexus. The area of 500 neurons of each group was investigated, as well as the neuronal density in an area of 23.84 mm2 in each stomach. ALC promoted reduction (P < 0.05) of fasting glycaemia, water ingestion and areas of the profiles of the cell bodies of the NADPH‐d neurons in the diabetic animals. The density of these neurons was not statistically different in the groups studied. It is suggested, therefore, a moderate neuroprotective effect of ALC, because the diminishment of the areas of the neuronal profiles in the supplemented diabetic animals, although being statistically significant relative to the non‐supplemented diabetics, was not sufficient to equal the values from the non‐diabetic controls.


Arquivos de Ciências da Saúde da UNIPAR | 2008

Avaliação quantitativa e morfométrica dos neurônios mioentéricos da região aglandular do estômago de ratos com diabetes mellitus induzido por estreptozootocina e suplementados com ácido ascórbico

Naianne Kelly Clebis; Sandra Regina Stabille; Carlos Eduardo Seyfert; Karina Martinez Gagliardo; Renata de Britto Mari; Juliana Plácido Guimarães; Sonia Lucy Molinari; Marcílio Hubner de Miranda Neto; J.N. Zanoni; Robson Marcelo Rossi; Vanderley Janeiro; Romeu Rodrigues de Souza


Arquivos de Ciências da Saúde da UNIPAR | 2015

EFEITOS DA SUPLEMENTAÇÃO COM ÁCIDO ASCÓRBICO SOBRE OS NEURÔNIOS MIOENTÉRICOS DO ESTÔMAGO DE RATOS DIABETICOS

Naianne Kelly Clebis; J.N. Zanoni; Sandra Regina Stabille; Marcelo José Santiago Lisboa; Marília Fabiana Pimentel de Oliveira; Sônia Luci Molinari; Marcílio Hubner de Miranda Neto; Karina Martinez Gagliardo; Romeu Rodrigues de Souza


Arq. ciências saúde UNIPAR | 2015

Efeitos da suplmmentação com ácido ascórbico sore os neurônios mioentéricos doo estômago de ratos diabeticos

Naianne Kelly Clebis; J.N. Zanoni; Sandra Regina Stabille; Marcelo José Santiago Lisboa; Marília Fabiana Pimentel de Oliveira; Sônia Luci Molinari; Marcílio Hubner de Miranda Neto; Karina Martinez Gagliardo; Romeu Rodrigues de Souza


Arquivos de Ciências da Saúde da UNIPAR | 2013

Effects of ascorbic acid supplementation on myenteric neurons in the stomach of diabetic rats.

Naianne Kelly Clebis; J.N. Zanoni; S. R. Stabille; Marcelo José Santiago Lisboa; M. F. P. de Oliveira; S. Luci; M. M. H. de Miranda Neto; Karina Martinez Gagliardo; R. R. de Souza


Autonomic Neuroscience: Basic and Clinical | 2011

Aging rats under ascorbic acid supplementation: Study of immunoreactive myenteric neurons of proximal colon to CGRP neurotransmitter

M.A. Defani; J.N. Zanoni; J.Z. Mata


Autonomic Neuroscience: Basic and Clinical | 2011

Immunohistochemical analysis of Interstitial Cells of Cajal in diabetic Wistar rats supplemented with quercetin

Flávia Cristina Vieira Frez; Sara Raquel Garcia de Souza; L.M. Perego; E.A. Moreira; J.N. Zanoni


Autonomic Neuroscience: Basic and Clinical | 2011

Ileum of diabetic rats (Rattus norvegicus): Effect of supplementation with 2% L-glutamine on glial cells and myenteric neurons

J.N. Zanoni; Eleandro Aparecido Tronchini; Cristiano Massao Tashima; Éder Paulo Belato Alves; Renata Virginia Fernandes Pereira

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Naianne Kelly Clebis

Federal University of Rio Grande do Norte

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Marcelo José Santiago Lisboa

Federal University of Rio Grande do Norte

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Sandra Regina Stabille

Universidade Estadual de Maringá

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M.H. Miranda Neto

Universidade Estadual de Maringá

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Roberto Barbosa Bazotte

Universidade Estadual de Maringá

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Sara Raquel Garcia de Souza

Universidade Estadual de Maringá

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C.G.S. Melo

University of São Paulo

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