J. Najman

Demographic correlates of psychotic-like experiences in young Australian adults

Objective:  Psychotic‐like experiences (PLE) in the general community are common. The aims of this study were to examine the prevalence and demographic correlates of PLE in young adults.

Early overweight and pubertal maturation-pathways of association with young adults' overweight : a longitudinal study

Objective:Objectives of this study were to examine the prospective association of childhood body mass index (BMI) and overweight and pubertal stages with BMI and overweight in early adulthood independent of each other.Design:A population-based prospective birth cohort.Subjects:We used a population-based prospective birth cohort of 2897 (52% men) young adults who were born during 1981–1983 in Brisbane, Australia, and for whom we had puberty stages using Tanner scale at 14 years and measured BMI at 5 years of age.Main outcome measures:Pubertal stages at adolescent and BMI and its categories at 21 years.Results:We found that increasing BMI and overweight at 5 years of age predict the advanced stages of puberty. An advanced stage of puberty predicts young adults’ BMI and overweight status at 21 years. When taking both childhood BMI and pubertal status into consideration, we found that being overweight at 5 years substantively increases BMI at 21 years, regardless of the stage of puberty reported at 14 years. We also found that subjects with normal BMI at 5 years but with higher stages of puberty at 14 years had threefolds greater risk to be overweight at 21 years compared with their counterparts. All associations remained consistent after controlling for potential confounders.Conclusions:Although this study underscores the impact of both child overweight and pubertal development on young adults’ obesity, the mechanism that further explainsthe impact of puberty needs to be identified.

THE RELATIONSHIP BETWEEN MATERNAL DEPRESSIVE, ANXIOUS, AND STRESS SYMPTOMS DURING PREGNANCY AND ADULT OFFSPRING BEHAVIORAL AND EMOTIONAL PROBLEMS

Prenatal maternal depressive, anxious, and stress symptoms have been found to be associated with child and adolescent behavior problems. In this paper, we investigate their impact on behavior problems and depressive symptoms in adulthood.

Does hypertensive disorder of pregnancy predict offspring blood pressure at 21 years? Evidence from a birth cohort study

Although few studies found that the offspring of women who experienced preeclampsia have higher blood pressure (BP) at childhood and adolescence, no study has observed whether this association exists for adult offspring. To examine whether maternal hypertensive disorder of pregnancy (HDP) predicts adult offspring BP. We followed a sub-sample of 2608 mother–offspring pairs for 21 years from an original cohort of 7223 singleton infants whose mothers gave birth in Brisbane, Australia between 1981 and 1983. HDP was defined as diastolic BP (DBP) over 90 mm Hg on at least two occasions beyond 20 weeks gestation associated with proteinuria and/or excessive fluid retention. Adult offsprings systolic BP (SBP) and DBP were measured at 21 years. Multivariable regressions were used to examine the independent associations of HDP with offspring BP. Unadjusted regression analysis showed that offspring of women who experienced HDP have 3.46 mm Hg greater SBP and 3.02 mm Hg greater DBP at 21 years. This association remained consistent after adjusting for potential confounding and mediating factors including offspring gender, age, percentile birth weight for gestation, placenta weight and body mass index (BMI) at 21 year, maternal age, education, racial origin, and smoking during pregnancy and their pre-pregnancy BMI. Findings of this study suggest that maternal HDP predicts adult offspring BP.

The Mental Health of Filipino-Born Women 5 and 14 Years after they have given Birth in Australia: A Longitudinal Study

Abstract It has been suggested that ‘Filipino brides’ may be ‘at risk’ of social isolation and mental health impairment after migrating to Australia to marry Australian men. This paper examines the mental health of a cohort of Filipino and Australian-born women who became mothers in Australia, and investigates the relationship between place of birth, social network size and symptoms of poor mental health. The data was taken from the Mater-University of Queensland Study of Pregnancy (MUSP), a longitudinal study of mothers and children instigated in 1981. Symptoms of anxiety and depression and social network size were assessed at their first clinic visit (FCV), and followed up at 5 and 14 years. Filipino-born mothers had smaller social networks at the birth of their child, and reported more symptoms of anxiety and depression at FCV and 5 years follow-up (F/U), but did not differ from their Australian counterparts 14 years later. We conclude that Filipino-born migrants experience greater distress and poorer social networks than Australian-born mothers in the early years after they have given birth to a child in Australia. Further, that over a period of time, the decrease in mental health symptoms indicates the adaptation of Filipino-born women to their new environment.

Parental supply of alcohol and alcohol consumption in adolescence: prospective cohort study

BACKGROUND Parents are a major supplier of alcohol to adolescents, yet there is limited research examining the impact of this on adolescent alcohol use. This study investigates associations between parental supply of alcohol, supply from other sources, and adolescent drinking, adjusting for child, parent, family and peer variables. METHOD A cohort of 1927 adolescents was surveyed annually from 2010 to 2014. Measures include: consumption of whole drinks; binge drinking (>4 standard drinks on any occasion); parental supply of alcohol; supply from other sources; child, parent, family and peer covariates. RESULTS After adjustment, adolescents supplied alcohol by parents had higher odds of drinking whole beverages [odds ratio (OR) 1.80, 95% confidence interval (CI) 1.33-2.45] than those not supplied by parents. However, parental supply was not associated with bingeing, and those supplied alcohol by parents typically consumed fewer drinks per occasion (incidence rate ratio 0.86, 95% CI 0.77-0.96) than adolescents supplied only from other sources. Adolescents obtaining alcohol from non-parental sources had increased odds of drinking whole beverages (OR 2.53, 95% CI 1.86-3.45) and bingeing (OR 3.51, 95% CI 2.53-4.87). CONCLUSIONS Parental supply of alcohol to adolescents was associated with increased risk of drinking, but not bingeing. These parentally-supplied children also consumed fewer drinks on a typical drinking occasion. Adolescents supplied alcohol from non-parental sources had greater odds of drinking and bingeing. Further follow-up is necessary to determine whether these patterns continue, and to examine alcohol-related harm trajectories. Parents should be advised that supply of alcohol may increase childrens drinking.

Exposure to stressful life events during pregnancy predicts psychotic experiences via behaviour problems in childhood

BACKGROUND Exposure to stressful life events during pregnancy has been associated with later schizophrenia in offspring. We explore how prenatal stress and neurodevelopmental abnormalities in childhood associate to increase the risk of later psychotic experiences. METHODS Participants from the Mater University Study of Pregnancy (MUSP), an Australian based, pre-birth cohort study were examined for lifetime DSM-IV positive psychotic experiences at 21 years by a semi-structured interview (n = 2227). Structural equation modelling suggested psychotic experiences were best represented with a bifactor model including a general psychosis factor and two group factors. We tested for an association between prenatal stressful life events with the psychotic experiences, and examined for potential moderation and mediation by behaviour problems and cognitive ability in childhood. RESULTS Prenatal stressful life events predicted psychotic experiences indirectly via behaviour problems at child age five years, and this relationship was not confounded by maternal stressful life events at child age five. We found no statistical evidence for an interaction between prenatal stressful life events and behaviour problems or cognitive ability. CONCLUSION The measurable effect of prenatal stressful life events on later psychotic experiences in offspring manifested as behaviour problems by age 5. By identifying early abnormal behavioural development as an intermediary, this finding further confirms the role of prenatal stress to later psychotic disorders.

Associations between self-reported symptoms of prenatal maternal infection and post-traumatic stress disorder in offspring: Evidence from a prospective birth cohort study

OBJECTIVE Consistent evidence has linked a range of prenatal maternal infections with psychotic disorders in later life. However, the potential for this exposure to impact more common disorders requires further investigation. METHODS Participants came from the Mater University Study of pregnancy, a longitudinal, pre-birth cohort study which recruited pregnant mothers from a Brisbane hospital between 1981 and 1984. At age 21, 2439 offspring completed the CIDI-Auto. Multivariate logistic regression was used to investigate associations of self-reported symptoms of prenatal infection with a range of DSM-IV anxiety and affective diagnoses, while also testing for gender interactions. RESULTS In multivariate analyses, self-reported symptoms of prenatal genital infection predicted Post-traumatic stress disorders (OR=2.38, 95% CI: 1.14, 4.95) and social phobias (OR=1.93, 95% CI: 1.03, 3.61), in addition to evidence for a gender interaction by which males (OR=6.04, 95% CI: 2.00, 18.30) but not females were at greater risk for PTSD. Further analyses among those with PTSD revealed the relationship to be stronger when excluding those not exposed to trauma (OR=3.21, 95% CI: 1.53, 6.72). LIMITATIONS We were unable to clinically or serologically verify the presence and the type of prenatal genital infection. CONCLUSION This is the first study to show an association between self-reported symptoms of prenatal genital infections and two highly prevalent anxiety disorders among adult offspring. The relationship with PTSD was particularly strong and suggested that the exposure may primarily impact PTSD in males. Further research with the capacity to assess a fuller-range of specific prenatal infections is warranted to evaluate the potential of reducing the prevalence of these disorders.

Young and not so drunk: Sipping, drinking and Australian adolescents

Issue: Harmful use of alcohol is a leading cause of disease burden for young Australians. Little is known about the context of adolescent alcohol initiation and the development of harmful patterns of consumption. This research reports descriptive baseline data from a national Australian longitudinal cohort. Approach: Parent-child dyads were recruited nationally via NSW, Tasmanian and WA secondary schools. During 2010/11, 1929 parent–child dyads completed baseline surveys. Measures include: alcohol use and harms; rules; parental style and monitoring; family relationships, confl ict and relations; peer substance use and approval; and delinquency. Key Findings: Sixty-eight percent of adolescents (M = 12.5 yrs) had tried alcohol. Parent factors including frequency and quantity of alcohol consumption (÷2 (3, N=1880) = 79.27, P < 0.00005; ÷2 (3, N=1879) = 63.75, P < 0.00005), drinking alcohol in the presence of their child (÷2 (3, N=1879) = 81.63, P < 0.00005) and younger age of alcohol initiation (÷2 (1, N=1785) = 20.13, P < 0.00005) were associated with adolescent alcohol initiation. Children with higher levels of rule breaking and aggressive behaviour (÷2 (1, N=1903) = 44.43, P < 0.0005; ÷2 (1, N=1893) = 13.40, P = 0.0003), who were male (÷2 (1, N=1904) = 6.72, P = 0.0095) and who had at least some friends who had tried alcohol (÷2 (3, N=1896) = 506.94, P < 0.00005) and who approved of drinking alcohol (÷2 (2, N=1903) = 91.21, P < 0.00005) were more likely to have tried alcohol themselves. Implications: To address current levels of binge drinking and long term harms from alcohol, it is essential to understand the context of early-adolescent alcohol use and how harmful trajectories may develop. Conclusion: Future analyses of this cohort will provide insight into the impact of contextual factors on adolescent alcohol use and inform public health policy and prevention.

Context of early adolescent alcohol use: First results from a longitudinal Australian cohort

Issue: Harmful use of alcohol is a leading cause of disease burden for young Australians. Little is known about the context of adolescent alcohol initiation and the development of harmful patterns of consumption. This research reports descriptive baseline data from a national Australian longitudinal cohort. Approach: Parent-child dyads were recruited nationally via NSW, Tasmanian and WA secondary schools. During 2010/11, 1929 parent–child dyads completed baseline surveys. Measures include: alcohol use and harms; rules; parental style and monitoring; family relationships, confl ict and relations; peer substance use and approval; and delinquency. Key Findings: Sixty-eight percent of adolescents (M = 12.5 yrs) had tried alcohol. Parent factors including frequency and quantity of alcohol consumption (÷2 (3, N=1880) = 79.27, P < 0.00005; ÷2 (3, N=1879) = 63.75, P < 0.00005), drinking alcohol in the presence of their child (÷2 (3, N=1879) = 81.63, P < 0.00005) and younger age of alcohol initiation (÷2 (1, N=1785) = 20.13, P < 0.00005) were associated with adolescent alcohol initiation. Children with higher levels of rule breaking and aggressive behaviour (÷2 (1, N=1903) = 44.43, P < 0.0005; ÷2 (1, N=1893) = 13.40, P = 0.0003), who were male (÷2 (1, N=1904) = 6.72, P = 0.0095) and who had at least some friends who had tried alcohol (÷2 (3, N=1896) = 506.94, P < 0.00005) and who approved of drinking alcohol (÷2 (2, N=1903) = 91.21, P < 0.00005) were more likely to have tried alcohol themselves. Implications: To address current levels of binge drinking and long term harms from alcohol, it is essential to understand the context of early-adolescent alcohol use and how harmful trajectories may develop. Conclusion: Future analyses of this cohort will provide insight into the impact of contextual factors on adolescent alcohol use and inform public health policy and prevention.