J. P. Glynn

Modification of the Response of Autochthonous Moloney Sarcoma Virus-induced Tumors to Poly I:C by DEAE-dx

Polyinosinic-polycytidylic acid (poly I:C) was shown to markedly inhibit the incidence and growth rate of Moloney sarcoma virus-induced tumor in BALB/c mice. The therapeutic effect observed with poly I:C alone was abrogated by the addition of DEAE-dx (diethylaminoethyl-dextran) to the poly I:C solution. Serum interferon titers were depressed 50% during the first 48 h of treatment with poly I:C plus DEAE-dx relative to those obtained with poly I:C alone. DEAE-dx stimulated the growth of Moloney sarcoma virus-induced tumors. Poly I:C on a schedule known to be tumor inhibitory failed to potentiate transplantation resistance to a specific tumor-associated transplantation antigen.