J. Ro

Effects of 7,8-dihydro-8-oxo-deoxyguanosine on antigen challenge in ovalbumin-sensitized mice may be mediated by suppression of Rac.

Background and purpose:  Earlier we reported that 7,8‐dihydro‐8‐oxo‐deoxyguanosine (8‐oxo‐dG), an oxidatively modified guanine nucleoside, exerted anti‐inflammatory activity through inactivation of the GTP binding protein, Rac. In the present study, the effects of 8‐oxo‐dG were investigated on responses to antigen challenge in sensitized mice, as Rac is also involved at several steps of the immune process including antigen‐induced release of mediators from mast cells.