J. S. Tandon

Anti-Inflammatory Activity of Pluchea lanceolata: Isolation of an Active Principle

AbstractThe ethanolic extract of Pluchea lanceolata exhibited significant anti-inflammatory activity, which was further localized in the hexane fraction, from which ψPS-taraxasterol acetate was isolated which proved to be one of the active constituents.

Coleonolic acid, a rearranged ursane triterpenoid from coleus forskohlII

Abstract Coleonolic acid, a novel rearranged pentacyclic triterpenoid isolated from the roots of Coleus forskohlii has been characterized as 2-hydroxymethyl A(1)nor-urs-19α-hydroxy-2(3), 12(13)dien-28-oic acid. The stereostructure has been determined by two-dimensional COSY, COSYLR, COSYDQF, XHDEPT, COLOC and NOE difference NMR experiments.

Effect of Coleus forskohlii against Caecal Amoebiasis of Rats

AbstractColeus forskohlii is reported to possess medicinal properties against human gut ailments. Coleonol (forskolin), a diterpene from this plant, was amoebicidal for trophozoites of Entamoeba histolytica at a cone, of 1000 /μg/ml. It showed therapeutic efficacy in clearing these amoebae from 50% infected rats at a high dose of 300 mg/kg body wt. Interestingly 67 and 64 % of rats respectively with caecal amoebiasis responded to treatment with dry root powder of this plant and its ethanolic extract fed at a dose of 900 mg/kg body wt.

Minor diterpenes from Coleus forskohlii

Abstract The structures of two new minor diterpenes, 1,9-dideoxy coleonol-B and 1-acetoxy coleosol, isolated from the roots of Coleus forskohlii have been shown to be 7-hydroxy-6-acetoxy, 13-epoxy labd-14-en-11-one and 1-acetoxy-6,9-dihydroxy, 13-epoxy labd-14-en-11-one, respectively, mainly through interpretation of 2D NMR data and X-ray analysis.

Epi-deoxycoleonol, a new antihypertensive labdane diterpenoid from Coleus forskohlii

Abstract A new antihypertensive labdane diterpenoid 13-epi-9-deoxycoleonol (13-epi-9-deoxyforskolin) has been isolated from the Indian medicinal plant Coleus forskohlii and the stereostructure of the diterpenoid ascertained by various two-dimensional NMR techniques

Stereoisomers of coleonol (forskolin) and related diterpenoids

Abstract Regioselective Mitsunobu inversion of the hydroxyl groups of coleonol (forskolin) led to new) unnatural epimers as potential adenylate cyclase stimulant and pharmacodynamic agents.

The synthesis of novel, rigid and water soluble analogues of coleonol (forskolin☆

The synthesis of new, rigid and water soluble analogues (3–6 of coleonol (forskolin) were carried out and evaluated for their antihypertensive activity. Among all the tested compounds, only 4 exhibited hypotensive activity.