J. Thomas Vaughan

Binocular Rivalry and Visual Awareness in Human Extrastriate Cortex

We used functional magnetic resonance imaging (fMRI) to monitor stimulus-selective responses of the human fusiform face area (FFA) and parahippocampal place area (PPA) during binocular rivalry in which a face and a house stimulus were presented to different eyes. Though retinal stimulation remained constant, subjects perceived changes from house to face that were accompanied by increasing FFA and decreasing PPA activity; perceived changes from face to house led to the opposite pattern of responses. These responses during rivalry were equal in magnitude to those evoked by nonrivalrous stimulus alternation, suggesting that activity in the FFA and PPA reflects the perceived rather than the retinal stimulus, and that neural competition during binocular rivalry has been resolved by these stages of visual processing.

The Retinotopy of Visual Spatial Attention

We used high-field (3T) functional magnetic resonance imaging (fMRI) to label cortical activity due to visual spatial attention, relative to flattened cortical maps of the retinotopy and visual areas from the same human subjects. In the main task, the visual stimulus remained constant, but covert visual spatial attention was varied in both location and load. In each of the extrastriate retinotopic areas, we found MR increases at the representations of the attended target. Similar but smaller increases were found in V1. Decreased MR levels were found in the same cortical locations when attention was directed at retinotopically different locations. In and surrounding area MT+, MR increases were lateralized but not otherwise retinotopic. At the representation of eccentricities central to that of the attended targets, prominent MR decreases occurred during spatial attention.

Imaging brain function in humans at 7 Tesla.

This article describes experimental studies performed to demonstrate the feasibility of BOLD fMRI using echo‐planar imaging (EPI) at 7 T and to characterize the BOLD response in humans at this ultrahigh magnetic field. Visual stimulation studies were performed in normal subjects using high‐resolution multishot EPI sequences. Changes in R  *2 arising from visual stimulation were experimentally determined using fMRI measurements obtained at multiple echo times. The results obtained at 7 T were compared to those at 4 T. Experimental data indicate that fMRI can be reliably performed at 7 T and that at this field strength both the sensitivity and spatial specificity of the BOLD response are increased. This study suggests that ultrahigh field MR systems are advantageous for functional mapping in humans. Magn Reson Med 45:588–594, 2001.

B1 destructive interferences and spatial phase patterns at 7 T with a head transceiver array coil

RF behavior in the human head becomes complex at ultrahigh magnetic fields. A bright center and a weak periphery are observed in images obtained with volume coils, while surface coils provide strong signal in the periphery. Intensity patterns reported with volume coils are often loosely referred to as “dielectric resonances,” while modeling studies ascribe them to superposition of traveling waves greatly dampened in lossy brain tissues, raising questions regarding the usage of this term. Here we address this question experimentally, taking full advantage of a transceiver coil array that was used in volume transmit mode, multiple receiver mode, or single transmit surface coil mode. We demonstrate with an appropriately conductive sphere phantom that destructive interferences are responsible for a weak B1 in the periphery, without a significant standing wave pattern. The relative spatial phase of receive and transmit B1 proved remarkably similar for the different coil elements, although with opposite rotational direction. Additional simulation data closely matched our phantom results. In the human brain the phase patterns were more complex but still exhibited similarities between coil elements. Our results suggest that measuring spatial B1 phase could help, within an MR session, to perform RF shimming in order to obtain more homogeneous B1 in user‐defined areas of the brain. Magn Reson Med, 2005.

Temperature and SAR calculations for a human head within volume and surface coils at 64 and 300 MHz

To examine relationships between specific energy absorption rate (SAR) and temperature distributions in the human head during radio frequency energy deposition in MRI.

Analysis of wave behavior in lossy dielectric samples at high field

Radiofrequency (RF) field wave behavior and associated nonuniform image intensity at high magnetic field strengths are examined experimentally and numerically. The RF field produced by a 10‐cm‐diameter surface coil at 300 MHz is evaluated in a 16‐cm‐diameter spherical phantom with variable salinity, and in the human head. Temporal progression of the RF field indicates that the standing wave and associated dielectric resonance occurring in a pure water phantom near 300 MHz is greatly dampened in the human head due to the strong decay of the electromagnetic wave. The characteristic image intensity distribution in the human head is the result of spatial phase distribution and amplitude modulation by the interference of the RF traveling waves determined by a given sample‐coil configuration. The numerical calculation method is validated with experimental results. The general behavior of the RF field with respect to the average brain electrical properties in a frequency range of 42–350 MHz is also analyzed. Magn Reson Med 47:982–989, 2002.

Whole-body imaging at 7T: Preliminary results

The objective of this study was to investigate the feasibility of whole‐body imaging at 7T. To achieve this objective, new technology and methods were developed. Radio frequency (RF) field distribution and specific absorption rate (SAR) were first explored through numerical modeling. A body coil was then designed and built. Multichannel transmit and receive coils were also developed and implemented. With this new technology in hand, an imaging survey of the “landscape” of the human body at 7T was conducted. Cardiac imaging at 7T appeared to be possible. The potential for breast imaging and spectroscopy was demonstrated. Preliminary results of the first human body imaging at 7T suggest both promise and directions for further development. Magn Reson Med 61:244–248, 2009.

High field magnetic resonance

This chapter deals with data and concepts relevant to high magnetic fields with the primary focus on efforts related to probing brain function and neurochemistry utilizing imaging and spectroscopy capabilities. One of the most important accomplishments in magnetic resonance imaging (MRI) research over the past years is the introduction of methods that can map the areas of altered neuronal activity in the brain, that is, functional MRI or fMRI. The most commonly used method of fMRI is based on blood oxygen level dependent (BOLD) contrast which is sensitive to the presence of deoxyhemoglobin. In an fMRI experiment, images are collected subsequent to signal excitation and echo formation, either by a gradient reversal or application of a refocusing radio frequency (RF) pulse. During the delay after excitation and before echo formation, it is possible to apply a pair of gradient pulses with opposing or same polarity depending on whether the experiment is a gradient recalled echo or a spinecho experiment, respectively.

High‐resolution, spin‐echo BOLD, and CBF fMRI at 4 and 7 T

With growing interest in noninvasive mapping of columnar organization and other small functional structures in the brain, achieving high spatial resolution and specificity in fMRI is of critical importance. We implemented a simple method for BOLD and perfusion fMRI with high spatial resolution and specificity. Increased spatial resolution was achieved by selectively exciting a slab of interest along the phase‐encoding direction for EPI, resulting in a reduced FOV and number of phase‐encoding steps. Improved spatial specificity was achieved by using SE EPI acquisition at high fields, where it is predominantly sensitive to signal changes in the microvasculature. Robust SE BOLD and perfusion fMRI were obtained with a nominal in‐plane resolution up to 0.5 × 0.5 mm2 at 7 and 4 Tesla, and were highly reproducible under repeated measures. This methodology enables high‐resolution and high‐specificity studies of functional topography in the millimeter to submillimeter spatial scales of the human brain. Magn Reson Med 48:589–593, 2002.

Activation of Neural Pathways Associated with Sexual Arousal in Non-Human Primates

To evaluate brain activity associated with sexual arousal, fully conscious male marmoset monkeys were imaged during presentation of odors that naturally elicit high levels of sexual activity and sexual motivation.