J.W. Stull

Rate of Transfer of DDT from the Blood Compartment

ConclusionsThe rate of decline of DDT from the blood has been shown to be quite rapid and recovery of pesticide from the blood has been related to the recovery of lipid from the blood.

The sub-cellullar partition and metabolism of oprally administered 1,1,1-Trichloro-2, 2-bis (p-chlorophenyl) ethane by rat liver cells

Abstract Uptake of orally administered DDT by rat liver cells has displayed the following characteristics: 1. The pesticide was not exclusively segregated from any one cell fraction. 2. Pesticide was depleted with time from all fractions. 3. A redistribution of pesticide occurred with time. A passive DDT distribution either occurs at some point in time or at low levels of exposure. 4. Non-lipid binding of pesticide appeared to occur. 5. Liver cells appeared to be detoxifying DDT to DDE and DDD by 16 hr post treatment.

Metabolism of toxaphene by the isolated perfused bovine liver

The metabolic fate of toxaphene was studied by perfusion experiments with isolated bovine livers. Metabolic patterns were elucidated by examining toxaphene components and toxaphene derived products in perfusate and liver tissue using gas liquid chromatography/electron capture detection. These patterns revealed that the bovine liver is capable of a very rapid uptake of toxaphene components from the blood followed by a rapid rate of dechlorination. The liver also accumulates partially dechlorinated products with a subsequentslow rate of further degradation.