J. W. Stutzman

Adrenolytic Action of Cyclopropane.

Conclusion Although cyclopropane initially sensitizes the dogs heart so that the injection of adrenalin causes ventricular tachycardia, subsequently it may exert an adrenolytic effect on the cardiovascular system.

Constancy of Urea Clearances in Dogs Following Surgical Anesthesias with Cyclopropane, Ether, and Chloroform.∗

Summary On a group of 5 adult female dogs maximal urea clearance determinations following anesthetization with cyclopropane, ether, or chloroform have shown no significant variations over a period of 8 months from control values. Ninety-one control determinations made on the 5 animals before anesthetization gave average clearance values of 34.9±6.1 cc per square meter per minute with a coefficient of variation of 17.6 and 83 determinations made after 19 anesthesias with the three agents averaged 35.2±5.9 cc per square meter per minute with a coefficient of variation of 16.6.†

Rôle of Thyroid in Cyclopropane-Adrenalin Tachycardia.

Summary Following thyroidectomy the duration of cyclopropane-adrenalin tachycardia was decreased in the dog. In the hyperthyroid state the period of tachycardia was longer than in the control.

Relationship of Chemical Structure of Sympathomimetic Amines to Ventricular Tachycardia during Cyclopropane Anesthesia

Fifteen additional sympathomimetic amines have been tested for their ability to produce ventricular tachycardia in the dog during cyclopropane anesthesia. In a dosage producing a blood pressure rise equal to that caused by 0.01 mgm. of adrenalin per kilogram, the six primary and secondary amines with a catechol nucleus consistently elicited ventricular tachycardia. Tertiary amines with a catechol nucleus and the other amines used did not cause this irregularity.