J. Y. T. Wei

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder

We are performing whole-genome sequencing of families with autism spectrum disorder (ASD) to build a resource (MSSNG) for subcategorizing the phenotypes and underlying genetic factors involved. Here we report sequencing of 5,205 samples from families with ASD, accompanied by clinical information, creating a database accessible on a cloud platform and through a controlled-access internet portal. We found an average of 73.8 de novo single nucleotide variants and 12.6 de novo insertions and deletions or copy number variations per ASD subject. We identified 18 new candidate ASD-risk genes and found that participants bearing mutations in susceptibility genes had significantly lower adaptive ability (P = 6 × 10−4). In 294 of 2,620 (11.2%) of ASD cases, a molecular basis could be determined and 7.2% of these carried copy number variations and/or chromosomal abnormalities, emphasizing the importance of detecting all forms of genetic variation as diagnostic and therapeutic targets in ASD.

Spectroscopic evidence for multiple order parameter components in the heavy fermion superconductor CeCoIn5.

Point-contact spectroscopy was performed on single crystals of the heavy-fermion superconductor CeCoIn(5) between 150 mK and 2.5 K. A pulsed measurement technique ensured minimal Joule heating over a wide voltage range. The spectra show Andreev-reflection characteristics with multiple structures which depend on junction impedance. Spectral analysis using the generalized Blonder-Tinkham-Klapwijk formalism for d-wave pairing revealed two coexisting order parameter components with amplitudes Delta(1) = 0.95 +/- 0.15 meV and Delta(2) = 2.4 +/- 0.3 meV, which evolve differently with temperature. Our observations indicate a highly unconventional pairing mechanism, possibly involving multiple bands.

Scanning tunneling spectroscopy study ofc-axis proximity effect in epitaxial bilayer manganite/cuprate thin films

Recent experimental studies have indicated novel superconducting proximity effects in thin-film heterostructures comprising ferromagnetic manganites and superconducting cuprates. To look for such effects microscopically, we performed scanning tunneling spectroscopy on La

Attenuation of superconductivity in manganite/cuprate heterostructures by epitaxially-induced CuO intergrowths

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Conductance characteristics between a normal metal and a two-dimensional Fulde-Ferrell-Larkin-Ovchinnikov superconductor: The Fulde-Ferrell state

Ca

Spin-Injection Quasiparticle Nonequilibrium in Cuprate/Manganite Heterostructures

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Andreev nanoprobe of half-metallic CrO2 films using superconducting cuprate tips

MnO

Lateral imaging of the superconducting vortex lattice using Doppler-modulated scanning tunneling microscopy

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Selective epitaxial growth of submicron complex oxide structures by amorphous SrTiO3

/YBa

Scanning tunneling spectroscopy under pulsed spin injection

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