Jacek Urbanek

Prediction of sustained harmonic walking in the free-living environment using raw accelerometry data

OBJECTIVEnUsing raw, sub-second-level accelerometry data, we propose and validate a method for identifying and characterizing walking in the free-living environment. We focus on sustained harmonic walking (SHW), which we define as walking for at least 10u2009s with low variability of step frequency.nnnAPPROACHnWe utilize the harmonic nature of SHW and quantify the local periodicity of the tri-axial raw accelerometry data. We also estimate the fundamental frequency of the observed signals and link it to the instantaneous walking (step-to-step) frequency (IWF). Next, we report the total time spent in SHW, number and durations of SHW bouts, time of the day when SHW occurred, and IWF for 49 healthy, elderly individuals.nnnMAIN RESULTSnThe sensitivity of the proposed classification method was found to be 97%, while specificity ranged between 87% and 97% and the prediction accuracy ranged between 94% and 97%. We report the total time in SHW between 140 and 10u2009min d-1 distributed between 340 and 50 bouts. We estimate the average IWF to be 1.7 steps-per-second.nnnSIGNIFICANCEnWe propose a simple approach for the detection of SHW and estimation of IWF, based on Fourier decomposition.

Automatic car driving detection using raw accelerometry data.

Measuring physical activity using wearable devices has become increasingly popular. Raw data collected from such devices is usually summarized as activity counts, which combine information of human activity with environmental vibrations. Driving is a major sedentary activity that artificially increases the activity counts due to various car and body vibrations that are not connected to human movement. Thus, it has become increasingly important to identify periods of driving and quantify the bias induced by driving in activity counts. To address these problems, we propose a detection algorithm of driving via accelerometry (DADA), designed to detect time periods when an individual is driving a car. DADA is based on detection of vibrations generated by a moving vehicle and recorded by an accelerometer. The methodological approach is based on short-time Fourier transform (STFT) applied to the raw accelerometry data and identifies and focuses on frequency vibration ranges that are specific to car driving. We test the performance of DADA on data collected using wrist-worn ActiGraph devices in a controlled experiment conducted on 24 subjects. The median area under the receiver-operating characteristic curve (AUC) for predicting driving periods was 0.94, indicating an excellent performance of the algorithm. We also quantify the size of the bias induced by driving and obtain that per unit of time the activity counts generated by driving are, on average, 16% of the average activity counts generated during walking.

Validation of Gait Characteristics Extracted from Raw Accelerometry during Walking Against Measures of Physical Function, Mobility, Fatigability, and Fitness

BackgroundnData collected by wearable accelerometry devices can be used to identify periods of sustained harmonic walking. This report aims to establish whether the features of walking identified in the laboratory and free-living environments are associated with each other as well as measures of physical function, mobility, fatigability, and fitness.nnnMethodsnFifty-one older adults (mean age 78.31) enrolled in the Developmental Epidemiologic Cohort Study were included in the analyses. The study included an in-the-lab component as well as 7 days of monitoring in-the-wild (free living). Participants were equipped with hip-worn Actigraph GT3X+ activity monitors, which collect raw accelerometry data. We applied a walking identification algorithm and defined features of walking, including participant-specific walking acceleration and cadence. The association between these walking features and physical function, mobility, fatigability, and fitness was quantified using linear regression analysis.nnnResultsnAcceleration and cadence estimated from in-the-lab and in-the-wild data were significantly associated with each other (p < .05). However, walking acceleration in-the-lab was on average 96% higher than in-the-wild, whereas cadence in-the-lab was on average 20% higher than in-the-wild. Acceleration and cadence were associated with measures of physical function, mobility, fatigability, and fitness (p < .05) in both in-the-lab and in-the-wild settings. In addition, in-the-wild daily walking time was associated with fitness (p < .05).nnnConclusionsnThe quantitative difference in proposed walking features indicates that participants may overperform when observed in-the-lab. Also, proposed features of walking were significantly associated with measures of physical function, mobility, fatigability, and fitness, which provides evidence of convergent validity.

Stride variability measures derived from wrist- and hip-worn accelerometers.

Many epidemiological and clinical studies use accelerometry to objectively measure physical activity using the activity counts, vector magnitude, or number of steps. These measures use just a fraction of the information in the raw accelerometry data as they are typically summarized at the minute level. To address this problem, we define and estimate two measures of temporal stride-to-stride gait variability based on raw accelerometry data: Amplitude Deviation (AD) and Phase Deviation (PD). We explore the sensitivity of our approach to on-body placement of the accelerometer by comparing hip, left and right wrist placements. We illustrate the approach by estimating AD and PD in 46 elderly participants in the Developmental Epidemiologic Cohort Study (DECOS) who worn accelerometers during a 400m walk test. We also show that AD and PD have a statistically significant association with the gait speed and sit-to-stand test performance.

Accelerometry data in health research: challenges and opportunities. Review and examples

Wearable accelerometers provide detailed, objective, and continu-ous measurements of physical activity (PA). Recent advances in technology and the decreasing cost of wearable devices led to an explosion in the popula-rity of wearable technology in health research. An ever increasing number of studies collect high-throughput, sub-second level raw acceleration data. In this paper we discuss problems related to the collection and analysis of raw acce-lerometry data and provide insights into potential solutions. In particular, we describe the size and complexity of the data, the within- and between-subject variability and the effects of sensor location on the body. We also provide a short tutorial for dealing with sampling frequency, device calibration, data labeling and multiple PA monitors synchronization. We illustrate these po-ints using the Developmental Epidemiological Cohort Study (DECOS), which collected raw accelerometry data on individuals both in a controlled and the free-living environment.

Total volume of physical activity: TAC, TLAC or TAC(λ)

We thank Wolff-Hughes and colleagues for their thoughtful response (Wolff-Hughes et al., 2017) to our recently published findings (Varma et al., 2017). Wolff-Hughes et al. correctly indicate that our findings, which model physical activity (PA) over the lifespan using total log-transformed activity counts (TLAC) as a proxy measure for total volume of PA, are inconsistent with their findings (Wolff-Hughes et al., 2014; Wolff-Hughes et al., 2015) that use total (non-transformed) activity counts (TAC). The main issue is whether TLAC or TAC is the most appropriate measure of total volume of PA. n nWe argue that 1) TAC most closely reflects moderate-to-vigorous PA (MVPA) while TLAC most closely reflects light-intensity PA (LiPA); and propose 2) TAC(λ) as a unifying measure to appropriately capture total volume of PA.

Patterns of sedentary and active time accumulation are associated with mortality in US adults: The NHANES study

Purpose Sedentary behavior has become a public health pandemic and has been associated with a variety of comorbidities including cardiovascular disease, type 2 diabetes, and some cancers. Previous studies have also shown that excessive amount of sedentary behavior is associated with all-cause mortality. However, no studies investigated whether patterns of sedentary and active time accumulation are associated with mortality independently of total sedentary and total active times. This study addresses this question by i) comparing several analytical ways to quantify patterns of both sedentary and active time accumulation through metrics of fragmentation of objectively-measured physical activity and ii) exploring the association of these metrics with all-cause mortality in a nationally representative US sample of elderly adults. Methods The accelerometry data of 3400 participants aged 50 to 84 in the National Health and Nutrition Examination Survey 2003-2006 cohorts were analyzed. Ten fragmentation metrics were calculated to quantify the duration of sedentary and active bouts: average bout duration, Gini index, average hazard, between-state transition probability, and the parameter of power law distribution. The association of these fragmentation metrics with all-cause mortality followed through December 31, 2011 was assessed with survey-weighted Cox proportional hazard models. Results In models adjusted for age, sex, race/ethnicity, education, body mass index, common comorbidities, and total sedentary/active time, four fragmentation metrics were associated with lower mortality risk: average active bout duration (HR=0.72 for 1SD increase, 95% CI = 0.590.88), Gini index for active bouts (HR = 0.75, 95% CI = 0.64-0.86), the parameter of power law distribution for sedentary bouts (HR = 0.75, 95% CI = 0.63-0.90), and sedentary-to-active transition probability (HR = 0.77, 95% CI = 0.61-0.96), and four fragmentation metrics were associated with higher mortality risk: the active-to-sedentary transition probability (HR = 1.40, 95% CI=1.23-1.58), the parameter of power law distribution for active bouts (HR = 1.33, 95% CI = 1.16-1.52), average hazard for durations of active bouts (HR = 1.32, 95% CI = 1.18-1.48), and average sedentary bout duration (HR =1.07, 95% CI = 1.01-1.13). After sensitivity analysis, average sedentary bout duration and sedentary-to-active transition probability became insignificant. Conclusion Longer average duration of active bouts, a lower probability of transitioning from active to sedentary behavior, and a higher normalized variability of active bout durations were strongly negatively associated with all-cause mortality independently of total active time. A larger proportion of longer sedentary bouts were positively associated with all-cause mortality independently of total sedentary time. The results also suggested a nonlinear association of average active bout duration with mortality that corresponded to the largest risk increase in subjects with average active bout duration less than 3 minutes.

Re-evaluating the effect of age on physical activity over the lifespan

Advancements in accelerometer analytic and visualization techniques allow researchers to more precisely identify and compare critical periods of physical activity (PA) decline by age across the lifespan, and describe how daily PA patterns may vary across age groups. We used accelerometer data from the 2003-2006 cohorts of the National Health and Nutrition Examination Survey (NHANES) (n=12,529) to quantify total PA as well as PA by intensity across the lifespan using sex-stratified, age specific percentile curves constructed using generalized additive models. We additionally estimated minute-to-minute diurnal PA using smoothed bivariate surfaces. We found that from childhood to adolescence (ages 6-19) across sex, PA is sharply lower by age partially due to a later initiation of morning PA. Total PA levels, at age 19 are comparable to levels at age 60. Contrary to prior evidence, during young adulthood (ages 20-30) total and light intensity PA increases by age and then stabilizes during midlife (ages 31-59) partially due to an earlier initiation of morning PA. We additionally found that males compared to females have an earlier lowering in PA by age at midlife and lower total PA, higher sedentary behavior, and lower light intensity PA in older adulthood; these trends seem to be driven by lower PA in the afternoon compared to females. Our results suggest a re-evaluation of how emerging adulthood may affect PA levels and the importance of considering time of day and sex differences when developing PA interventions.