Jack R. Cole

Cardenolides and a lignan from Asclepias subulata

Abstract Four new glycosides (three cardenolides and a lignan), nine previously reported cardenolide glycosides and a known triterpenoid were isolated from the ethyl acetate extract of the aerial parts of Asclepias subulata . The elucidation of the structures and stereochemistry of the new glycosides has been accomplished using mainly 1 H and 13 C NMR and mass (EI and FAB) spectral data of their acetyl derivatives and comparison of these data with those of known glycosides from the same plant as well as from other plants. The new compounds were identified as 16α-hydroxycalactin, 3β-(β- D -glucopyranosyloxy)-19-car coroglaucigenin 3β- D -glucoside and 4-(β- D -glucopyranosyloxy)-larciresinol.

1-Epizeylenol from Uvaria zeylanica roots

Abstract 1-Epizeylenol was isolated from Uvaria zeylanica roots and characterized, largely by 1 H and 13 CNMR spectral comparisons with zeylenol.

Petalostetin, a new isoflavone from Petalostemon candidum

occurrence and it is significant because the oestrogenic Si gel. Using petrol with increasing amounts of C,H, as activity of a synthetic sample was found to be one fourth eluent sitosterol, lupeol, and rand p-amyrin were of that of the isomeric 5.7,4’-trihydroxyisoflavone [4]. isolated and identified by direct comparison with authenA comparison of the UV values of the aglucone with tic samples. those of the glucoside suggested the presence of the sugar moiety at position 7. Methylation of the glucoside with CH,N, for 30 hr and subsequent hydrolysis gave a Acknow!rtlgrinent -The authors are grateful to Prof. R. H.

Sesquiterpenoids from Coreocarpus arizonicus

Abstract Ten sesquiterpenoids were isolated from the methylene chloride extract of Coreocarpus arizonicus . Five were new, identified on the basis of spectral data as 1 ( R ), 4( R ), 7( S )- and 1( S ), 4( S ), 7( S )-bisabol-2-en- 1,4-diols and dimers of perezone (biperezone) and its 12-(2-methylbutyroxyl) and 12-isovaleroxyl derivatives oxidatively coupled through C-4. The known sesquiterpenoids were costunolide, dihydrocostunolide, perezone, α-pipitzol and spathulenol.

Terpenoids from Acamptopappus sphaerocephalus and A. shockleyi

Abstract Eight new labdane diterpenoids were isolated from the sodium carbonate-soluble acid fraction of Acamptopappus sphaerocephalus and their structures were deduced from the spectral properties of their methyl esters and other derivatives. They are 7, E -13- or 8, E -13-labdadienes having oxygen-containing substituents at C-2, C-7, C-15 and/or C-19. These same diterpenoids were also present in A. shockleyi . Eight previously reported sesquiterpenoids, namely, bisabolene-1,4-endoperoxide, caryophyllene oxide, β-eudesmol, trans -nerolidol, 1-oxobisabolene, shiromool, spathulenol and viridiflorol, were isolated from the non-polar fraction of A. sphaerocephalus and identified by their 1 H NMR spectra.