Jacqueline D. Hicks
Merck & Co.
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Publication
Featured researches published by Jacqueline D. Hicks.
Journal of Medicinal Chemistry | 2014
Tesfaye Biftu; Ranabir SinhaRoy; Ping Chen; Xiaoxia Qian; Dennis Feng; Jeffrey T. Kuethe; Giovanna Scapin; Ying Duo Gao; Youwei Yan; Davida Krueger; Annette Bak; George J. Eiermann; Jiafang He; Jason M. Cox; Jacqueline D. Hicks; Kathy Lyons; Huaibing He; Gino Salituro; Sharon Tong; Sangita B. Patel; George A. Doss; Aleksandr Petrov; Joe C. Wu; Shiyao Sherrie Xu; Charles Sewall; Xiaoping Zhang; Bei Zhang; Nancy A. Thornberry; Ann E. Weber
In our effort to discover DPP-4 inhibitors with added benefits over currently commercially available DPP-4 inhibitors, MK-3102 (omarigliptin), was identified as a potent and selective dipeptidyl peptidase 4 (DPP-4) inhibitor with an excellent pharmacokinetic profile amenable for once-weekly human dosing and selected as a clinical development candidate. This manuscript summarizes the mechanism of action, scientific rationale, medicinal chemistry, pharmacokinetic properties, and human efficacy data for omarigliptin, which is currently in phase 3 clinical development.
Archive | 2009
Rajan Anand; James M. Apgar; Tesfaye Biftu; Ping Chen; Lin Chu; Vincent J. Colandrea; Guizhen Dong; James F. Dropinski; Danqing Feng; Jacqueline D. Hicks; Jinlong Jiang; Alexander J. Kim; Kenneth J. Leavitt; Bing Li; Xiaoxia Qian; Iyassu K. Sebhat; Lan Wei; Robert R. Wilkening; Zhicai Wu
Archive | 2013
James M. Apgar; Ashok Arasappan; Tesfaye Biftu; Ping Chen; Danqing Feng; Erin N. Guidry; Jacqueline D. Hicks; Ahmet Kekec; Kenneth J. Leavitt; Bing Li; Troy Mccracken; Iyassu K. Sebhat; Xiaoxia Qian; Lan Wei; Robert R. Wilkening; Zhicai Wu
Archive | 2011
Jacqueline D. Hicks; Tesfaye Biftu; Ping Chen; Xiaoxia Qian; Robert R. Wilkening
Archive | 2013
James M. Apgar; Tesfaye Biftu; Ping Chen; Danqing Feng; Jacqueline D. Hicks; Ahmet Kekec; Kenneth J. Leavitt; Bing Li; Iyassu K. Sebhat; Xiaoxia Qian; Lan Wei; Robert R. Wilkening; Zhicai Wu
Archive | 2013
James M. Apgar; Tesfaye Biftu; Ping Chen; Danqing Feng; Jacqueline D. Hicks; Ahmet Kekec; Kenneth J. Leavitt; Bing Li; Iyassu K. Sebhat; Xiaoxia Qian; Lan Wei; Robert R. Wilkening; Zhicai Wu
Archive | 2013
James M. Apgar; Tesfaye Biftu; Ping Chen; Danqing Feng; Jacqueline D. Hicks; Ahmet Kekec; Kenneth J. Leavitt; Bing Li; Iyassu K. Sebhat; Xiaoxia Qian; Lan Wei; Robert R. Wilkening; Zhicai Wu; Ashok Arasappan
Archive | 2015
Mihir Mandal; Haifeng Tang; Li Xiao; Jing Su; Guoqing Li; Shu-Wei Yang; Weidong Pan; Haiqun Tang; Reynalda Dejesus; Jacqueline D. Hicks; Matthew Lombardo; Hong Chu; William K. Hagmann; Alex Pasternak; Xin Gu; Jinlong Jiang; Shuzhi Dong; Fa-Xiang Ding; Clare London; Dipshikha Biswas; Katherine Young; David N. Hunter; Zhiqiang Zhao; Dexi Yang
Archive | 2018
James M. Apgar; Tesfaye Biftu; Ping Chen; Danqing Feng; Jacqueline D. Hicks; Ahmet Kekec; Kenneth J. Leavitt; Bing Li; Iyassu K. Sebhat; Xiaoxia Qian; Lan Wei; Robert R. Wilkening; Zhicai Wu; Ashok Arasappan
Archive | 2013
James M. Apgar; Tesfaye Biftu; Ping Chen; Danqing Feng; Jacqueline D. Hicks; Ahmet Kekec; Kenneth J. Leavitt; Bing Li; Iyassu K. Sebhat; Xiaoxia Qian; Lan Wei; Robert R. Wilkening; Zhicai Wu; Ashok Arasappan
