Jacques W. A. J. Reeders

Palliation of patients with esophagogastric neoplasms by insertion of a covered expandable modified Gianturco-Z endoprosthesis: experiences in 153 patients☆☆☆

BACKGROUND We aimed to evaluate the short- and long-term outcomes of treatment by insertion of a covered expandable modified Gianturco-Z endoprosthesis (Song stent) in patients with esophagogastric malignancies. METHODS Consecutive patients with esophagogastric malignancies in whom a Song stent was inserted were included. Data were retrieved retrospectively. Dysphagia before and after stent placement was scored on a 5-point scale. Early (less than 30 days) and late complications (more than 30 days) were scored. RESULTS Analysis included 164 stents in 153 patients. Indications for stent placement were dysphagia and/or fistulas/perforations. The dysphagia score improved from a mean of 3.7 to 2.2 after stent placement (p < 0.0001). Fistulas/perforations sealed in 87% of cases. Early complications after stent placement occurred in 29.9% of cases. These included stent migration (4.3%), stent obstruction (6. 1%), aspiration pneumonia (4.9%), bleeding (4.3%), perforation (1. 8%), and pain (15.9%). Late complications occurred in 27.8% of cases. These included stent migration (2.6%), stent obstruction (9.6%), aspiration pneumonia (2.6%), bleeding (7.0%), perforation (0.9%), and pain (12.2%). The 30-day mortality was 26%. Death related to stent placement occurred in 3.3%. CONCLUSION Insertion of a Song expandable endoprosthesis in patients with esophagogastric malignancies significantly improves dysphagia, is successful in sealing fistulas/perforations, and is associated with acceptable morbidity and mortality rates.

Value of laparoscopic ultrasonography in staging of proximal bile duct tumors

The additional value of laparoscopic ultrasonography was evaluated prospectively in 35 patients undergoing diagnostic laparoscopy for a suspected potentially resectable proximal bile duct tumor. Findings were compared with transabdominal ultrasonography, laparoscopy, surgery, and pathology. Laparoscopic ultrasonography was able to visualize the presence and origin of small bile duct tumors or stones and small liver metastases, which could not be seen or could be visualized only doubtfully by ultrasonography and laparoscopy. Laparoscopic ultrasonography was more useful in staging of small tumors of the gallbladder or proximal common bile duct than in staging bifurcation (Klatskin) tumors. Additional information provided by laparoscopic ultrasonography led to a change in diagnosis or tumor stage in eight patients (23%) and to avoidance of laparotomy in three patients (9%).

Primary sclerosing cholangitis: sonographic findings

Background:To determine the value of sonography of the upper abdomen in primary sclerosing cholangitis (PSC).Methods:In a prospective study of 23 patients with PSC we performed upper abdominal sonography. Sonographic findings of the bile ducts were correlated with endoscopic retrograde cholangiographic (ERC) findings. Signs of advanced disease and complications were also sought.Results:The major limitation of ultrasound was its inability to exclude intrahepatic duct disease. In six patients with multiple strictures and pruning but without dilatations on ERC, sonography showed no intrahepatic duct abnormalities. Extrahepatic duct disease was adequately demonstrated on ultrasound. Mural thickening of the common bile duct (CBD), the hallmark of PSC in the appropriate clinical setting, was demonstrated in 17 of 18 cases with a stenosis on ERC. Ultrasound confirmed advanced disease manifested by signs of portal hypertension in seven patients. Marked nonsegmental intrahepatic duct dilatation and the presence of a mass lesion occurred in two of three cases in which complicating cholangiocarcinoma was found.Conclusion:Despite its inability to exclude intrahepatic duct disease, sonography is useful in diagnosing and following PSC.

Comparison of laparoscopic and transabdominal ultrasonography in staging of cancer of the pancreatic head region

The value of laparoscopic ultrasonography in the staging of cancer of the pancreatic head region was compared prospectively to that of transabdominal ultrasonography. Eighty patients underwent LUS, after ultrasonography had shown normal Doppler findings of portal vessels and no signs of metastatic disease. Presence of hepatic or lymph node metastases and vascular tumor infiltration were evaluated in 74 and 48 patients, respectively. Laparoscopic ultrasonography showed liver metastases in 10 patients (14%). Specificity and positive predictive value for the laparoscopic technique determining vascular ingrowth were 97% and 92%, respectively, versus 89% and 77% by sonography in patients with normal Doppler findings (difference not statistically significant). Laparoscopic ultrasonography has shown improved detection of hepatic metastases compared to sonography, but it still must prove its value, as compared to noninvasive methods, in local staging.

Evaluation of a modified cholangiographic classification system for primary sclerosing cholangitis.

AbstractBackground: There is no uniformly accepted classification system for the range of cholangiographic abnormalities encountered in primary sclerosing cholangitis (PSC). The aims of this study were to evaluate a previously developed classification system and to test the hypothesis that the pancreatic duct can be involved in PSC. Methods: Two observers scored 132 endoscopic retrograde cholangiopancreatographies (ERCPs) from established PSC patients. From 30 patients, subsequent ERCPs were scored and compared with the initial ERCPs. The pancreatic duct was judged with regard to morphologic abnormalities. Results: The classification system was applicable in 107 patients. In 10 ERCPs (7.6%), no clear intrahepatic abnormalities were found; 15 other ERCPs (11.4%) did not show extrahepatic abnormalities. In 30 cases, a subsequent ERCP was judged. The difference in scoring between the initial and the subsequent ERCPs was statistically significant, with the subsequent ERCP having higher intrahepatic and extrahepatic scores. Sixty-four adequately filled pancreatic ducts were analyzed. In two cases (3.1%), morphologic abnormalities were found. Conclusions: The previously developed scoring system is very applicable for almost all PSC patients when supplemented with a type 0 category. Scoring increased over time, suggesting a correlation with disease severity. The pancreatic duct does not seem to be involved in PSC.

Clinical radiology and endoscopy of the colon

Comprehensive in scope and beautifully presented, this important work covers all imaging techniques for the colon - plain x-ray, contrast-medium imaging, endoscopy, sonography, endosonography, CT and MRI. Etiology, pathology and clinical findings are also dealt with. More than 500 outstanding illustrations. Lists of differential diagnoses, indications, contraindications and postoperative complications.

Laparoscopic ultrasonography for abdominal tumor staging: technical aspects and imaging findings

Abstract. Since 1992 diagnostic laparoscopy combined with laparoscopic ultrasonography has been performed in our center in more than 300 patients for staging of tumors of the liver, bile ducts, pancreas, esophagus, and gastric cardia. In this article our experience with laparoscopic ultrasonography for abdominal tumor staging is described, with particular attention for the technical aspects, imaging findings, limitations, and pitfalls.

Dynamic rectal examination (defecography)

Dynamic rectal examination (DRE), first described in 1952, is becoming more widely used in the dynamic evaluation of pelvic floor and anorectal motility disorders. It is a minimally invasive investigation which is well tolerated by patients and provides information about the anosphincteric, puborectal and levator muscle in addition to insight in rectal function and structure. DRE is the only investigation of anorectal function that can give detailed anatomical information such as the presence of a rectocele, an enterocele and an intussusception. DRE should be performed in a quiet environment with a minimum number of investigators present. Any technique which attempts to study the defecatory mechanism must be a compromise since the patient is aware of being studied. In order to defecate on command the radiologist must make the patient comfortable before starting the investigative procedures to avoid any possible psychological inhibition. We have not encountered any failures in this regard. The relative value of the radiological findings with respect to symptoms and complaints is insufficiently known. This has been the main incentive to design carefully and carry out a large prospective critical evaluation of various aspects of DRE in particular the correlation with objective findings and symptoms. Moreover an assessment has been made of its overall clinical utility (Wiersma, 1994). It is very likely that DRE is both investigator- and technique-dependent. To ensure that the study is as physiological as possible the contrast medium used to fill the rectum needs to be semi-solid and malleable equivalent in consistency to a normal faecal bolus. For proper anatomical studies in females vaginal opacification is mandatory. The acceptance of vaginal contrast was good. Only 4% of the female patients preferred not to have the vaginal application of contrast. The technique of DRE when performed with small bowel and vaginal opacification provides a sensitive and objective method of detecting enteroceles. A substantial number of female patients related the onset of their complaints to hysterectomy. In female patients with constipation there was a significantly higher incidence of enteroceles in patients with a hysterectomy compared to the group of females without hysterectomy. Because of these findings a series of pre- and postoperative DREs in hysterectomy patients are on their way in our institute. Unlike a rectocele which is usually most obvious during defecation, enteroceles are sometimes appreciated only with repeated straining after evacuation.(ABSTRACT TRUNCATED AT 400 WORDS)

Laparoscopic ultrasonography for abdominal tumor staging

Abstract. In recent years, laparoscopic ultrasonography has been introduced as an adjunct to diagnostic laparoscopy for staging of tumors of the upper gastrointestinal tract, liver, biliary tree, and pancreas. It has proved feasible to visualize most anatomic structures in the upper abdomen consistently and in detail with laparoscopic ultrasonography. Recent publications indicate that laparoscopic ultrasonography may be useful for detecting small liver metastases, lymph node metastases, small primary tumors of the pancreas and bile ducts, and for the assessment of the local extension of tumors of the pancreas and stomach. The ongoing improvements in US technology and the results of larger studies will in the near future determine the precise place of this new imaging modality for staging of abdominal tumors.

Primary sclerosing cholangitis

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