Jade Cartwright

A comparison of aphasia therapy outcomes before and after a Very Early Rehabilitation programme following stroke

BACKGROUND Very early aphasia rehabilitation studies have shown mixed results. Differences in therapy intensity and therapy type contribute significantly to the equivocal results. AIMS To compare a standardized, prescribed very early aphasia therapy regimen with a historical usual care control group at therapy completion (4-5 weeks post-stroke) and again at follow-up (6 months). METHODS & PROCEDURES This study compared two cohorts from successive studies conducted in four Australian acute/sub-acute hospitals. The studies had near identical recruitment, blinded assessment and data-collection protocols. The Very Early Rehabilitation (VER) cohort (N = 20) had mild-severe aphasia and received up to 20 1-h sessions of impairment-based aphasia therapy, up to 5 weeks. The control cohort (n = 27) also had mild-severe aphasia and received usual care (UC) therapy for up to 4 weeks post-stroke. The primary outcome measure was the Aphasia Quotient (AQ) and a measure of communicative efficiency (DA) at therapy completion. Outcomes were measured at baseline, therapy completion and 6 months post-stroke and were compared using Generalised Estimating Equations (GEE) models. OUTCOMES & RESULTS After controlling for initial aphasia and stroke disability, the GEE models demonstrated that at the primary end-point participants receiving VER achieved 18% greater recovery on the AQ and 1.5% higher DA scores than those in the control cohort. At 6 months, the VER participants maintained a 16% advantage in recovery on the AQ and 0.6% more on DA scores over the control cohort participants. CONCLUSIONS & IMPLICATIONS A prescribed, impairment-based aphasia therapy regimen, provided daily in very early post-stroke recovery, resulted in significantly greater communication gains in people with mild-severe aphasia at completion of therapy and at 6 months, when compared with a historical control cohort. Further research is required to demonstrate large-scale and long-term efficacy.

Promoting collaborative dementia care via online interprofessional education

This study aimed to develop, implement and evaluate an online interprofessional education (IPE) dementia case study for health science students. The IPE initiative aimed to develop collaborative interprofessional capabilities and client‐centred mindsets that underpin high‐quality dementia care.

Constraint-induced aphasia therapy (CIAT): a randomised controlled trial in very early stroke rehabilitation

Background: Communication outcomes following stroke are improved when treatments for aphasia are administered early, within the first 3 months after stroke, and provided for more than 2 hours per week. However, uncertainty remains about the optimal type of aphasia therapy. Aims: We compared constraint-induced aphasia therapy (CIAT) with individual, impairment-based intervention, both administered early and daily after acute stroke. Methods & Procedures: This prospective, single-blinded, randomised, controlled trial recruited participants with mild to severe aphasia within 10 days of an acute stroke from acute/subacute Perth metropolitan hospitals (n = 20). Participants were allocated by computer-generated block randomisation method to either the CIAT (n = 12) or individual, impairment-based intervention group (n = 8) delivered at the same intensity (45–60 min, 5 days a week) for 20 sessions over 5 weeks (15–20 hours total). The primary outcome, measured after completing the intervention, was the Aphasia Quotient (AQ) from the Western Aphasia Battery. Secondary outcomes were the AQ at 12 and 26 weeks post stroke, a Discourse Analysis (DA) score and the Stroke and Aphasia Quality of Life Scale (SAQoL), measured at therapy completion, 12 and 26 weeks post stroke. There was a 10% (n = 2) dropout at the primary end point, both participants were in the CIAT group. The estimates for each treatment group were compared using repeated measures ANOVAs. Data from the 26-week follow-up assessment are presented, however, were not included in the between-group comparisons due to the low number of data points in each group. Outcomes & Results: Within groups analyses comparing performance at baseline, therapy completion, and 12 weeks post stroke revealed a statistically significant treatment effect for the AQ (p < .001), DA (p = .002), and SAQoL (p < .001). Between groups analysis found there was no significant difference between the CIAT and individual therapy groups on any outcome measure. Conclusions: CIAT and individual therapy produced comparable amounts of change in the very early phase of recovery suggesting a standard, intensive daily dose of therapy within this period of recovery is feasible and beneficial. There were no significant differences between the two groups demonstrating that CIAT, which is provided in a group format, may be a viable option in the very early phase of aphasia recovery. The study highlights the need for further research into the impact of therapy type in very early aphasia therapy.

The bedside assessment practices of speech-language pathologists in adult dysphagia.

Abstract Purpose: The current study aimed to investigate what Australian speech-language pathologists frequently include in their bedside assessments in adult dysphagia, what factors influence these bedside assessments and whether they are consistent with the current evidence base. Method: These aims were achieved via an online questionnaire and a series of semi-structured interviews. In the questionnaire, respondents were asked to rate how frequently they utilized bedside assessment components on a scale of five ranging from never to always. Result: One hundred and forty practicing speech-language pathologists completed the online questionnaire in full. Eight interviews were then conducted. Respondents reported utilizing predominantly motor elements of their oro-motor examination with very few sensory elements being frequently utilized. Five main themes arose from the interviews including the influence of the individual patient and participant, the current evidence base, the participants’ clinical practice and the participants’ workplace. Conclusion: The findings from this research have implications for current clinical and education practices, in particular the impact of education and training and caseload demands on current practice.

Inhibitory control and traumatic brain injury: The association between executive control processes and social communication deficits

Abstract Primary objective: To further examine the proposed relationship between executive impairments in inhibitory control and social communication difficulties reflecting poor inhibition following TBI. Method: Inhibitory control was assessed in 14 adults with TBI on the Hayling Sentence Completion Test (HSCT). Errors on Part B (failed inhibition) and Part B-Part A response latencies (delayed inhibition) were examined. A relative, friend or frequent communication partner of each participant with TBI completed the La Trobe Communication Questionnaire (LCQ) on the communication difficulties of the person with TBI. The Inhibitory Control Factor (ICF) score of the LCQ based on seven items relating to poor inhibition was specifically analysed against performance on the HSCT. Results: Multiple regression analysis indicated that 58% (51% adjusted) of the variance in LCQ ICF scores was accounted for by measures on the HSCT. Only B–A response latencies on the HSCT explained a significant proportion of the variability in LCQ ICF scores. Conclusions: Reduced inhibition speed may more strongly contribute to disinhibited communication behaviours than failures in inhibition. These findings contribute to understanding of the cognitive processes underlying social communication and have the potential to support and inform the use and development of management practices for individuals following TBI.

Determining stability in connected speech in primary progressive aphasia and Alzheimer’s disease

Abstract Purpose: Using connected speech to assess progressive language disorders is confounded by uncertainty around whether connected speech is stable over successive sampling, and therefore representative of an individual’s performance, and whether some contexts and/or language behaviours show greater stability than others. Method: A repeated measure, within groups, research design was used to investigate stability of a range of behaviours in the connected speech of six individuals with primary progressive aphasia and three individuals with Alzheimer’s disease. Stability was evaluated, at a group and individual level, across three samples, collected over 3 weeks, involving everyday monologue, narrative and picture description, and analysed for lexical content, fluency and communicative informativeness and efficiency. Result: Excellent and significant stability was found on the majority of measures, at a group and individual level, across all genres, with isolated measures (e.g. nouns use, communicative efficiency) showing good, but greater variability, within one of the three genres. Conclusion: Findings provide evidence of stability on measures of lexical content, fluency and communicative informativeness and efficiency. While preliminary evidence suggests that task selection is influential when considering stability of particular connected speech measures, replication over a larger sample is necessary to reproduce findings.

Taking words to a new level: a preliminary investigation of discourse intervention in primary progressive aphasia

ABSTRACT Background: Despite a growing literature characterising connected speech and discourse impairments associated with primary progressive aphasia (PPA), intervention in PPA has focused predominantly on lexical retrieval and picture-naming treatments, with limited generalisation of therapy gains reported. Recent developments in the post-stroke aphasia literature with discourse-level approaches have provided highly promising findings for the generalisation of language gains to everyday communication, and an opportunity to investigate whether the same benefits may be found in the PPA population. Aims: This study evaluated the effectiveness of a discourse intervention in two individuals with PPA to determine whether significant improvements were seen in word retrieval and discourse organisation in everyday discourse. Methods & Procedures: KW, a 54-year-old man, who presented with semantic variant PPA, and AS, a 59-year-old woman, presenting with logopenic variant PPA, completed the NARNIA intervention programme (Whitworth, Leitão et al., 2015) in 20 sessions over a 10-week period. Discourse performance was sampled prior to intervention across 10 tasks involving four different genres, at one time point, and compared to performance immediately and four weeks post intervention. The multilevel intervention protocol aimed to increase awareness of word retrieval, sentence structure, and macrostructure of a range of discourse genre. Outcomes & Results: Both participants made significant gains in discourse production immediately after intervention and when reassessed four weeks later, in the absence of change on naming tasks and in the context of stable overall cognitive performance. Significant gains were seen in the amount of overall output, noun and verb usage, and the number of body elements in macrostructure in everyday discourse in topics that were not trained in treatment. Further to the findings of the original NARNIA study in post-stroke aphasia, significant gains were also seen in narrative discourse across lexical categories for both participants. Informativeness and efficiency of communication also improved significantly for KW across all genres. Both participants reported significant gains in measures of social communication and participation. Conclusions: The study suggests that improvements in everyday discourse may be possible when the discourse level is directly targeted, that lexical access can improve in the absence of targeting lexical items, and that discourse-level interventions have the potential to impact real-life communication in individuals with PPA. As the first known study to trial a multilevel intervention in the context of PPA, the findings may be of clinical and theoretical significance, and warrant further investigation.

Just how stable is our discourse? A hurdle for measuring therapeutic change (or not)

Background: Working at the level of discourse with people with acquired neurological disorders has thrown up a new set of challenges for how we measure language change. Promising, novel interventions have highlighted the advantages of measuring language behaviours across the linguistic levels within discourse (e.g., Whitworth et al., 2015). Our confidence, however, in knowing whether change seen in discourse can be attributed to therapy is compromised by our belief in the inherent variability of discourse. Studies of healthy speakers have predominantly examined inter-individual reliability, showing high levels of variability. In contrast, less is known of intra-individual variability, but the small literature highlights variability in both healthy speakers and people with aphasia. Only one earlier study has examined intra-individual variability in progressive conditions, with inconclusive findings. Clinicians therefore remain uncertain as to whether connected speech is consistent across successive sampling points, leaving us unsure as to the number of baseline samples we need before we are confident that we have a reliable measure of pre-intervention performance. Equally, we continue to question whether connected speech is really so variable from one day to the next, from week to week, that we may be unable to reliably capture any meaningful change. Aims: This paper will report on a series of studies examining the stability of monologic discourse production in healthy adult speakers and clinical populations, including people with primary progressive aphasia (PPA), Alzheimer’s disease (AD), and post-stroke aphasia, and which have explored the intra-individual stability of language characteristics across time, sampling conditions and discourse genres. Methods and procedures: The discourse production of 28 healthy adult speakers (40–60 years, equal gender), randomly assigned to two sampling conditions of 1 and 3 weeks apart, and 19 people with a progressive language impairment (PPA or AD) or post-stroke aphasia, was assessed over three sampling points and across a range of monologic discourse genres to examine intra-individual variability. Clinical populations were measured in three successive sessions, with no intervening speech-language intervention. Discourse was collected using a standard elicitation protocol and analysed using Correct Information Unit (CIU) analysis (Nicholas & Brookshire, 1993) of Informativeness and Efficiency, and from measures of lexical content, fluency, and/or macrostructure analysis (Whitworth, Claessen, Leitão, & Webster, 2015). Test–retest

A review of lexical retrieval intervention in primary progressive aphasia and Alzheimer’s disease: mechanisms of change, generalisation, and cognition

ABSTRACT Background: While significant benefits of lexical retrieval intervention are evident within the primary progressive aphasia (PPA) and Alzheimer’s disease (AD) literature, an understanding of the mechanisms that underlie change is limited. Change mechanisms have been explored in the post-stroke aphasia literature and offer insight into how change occurs through interventions with progressive language disorders. Exploration of change mechanisms may progress our understanding as to how and why generalisation is likely, or not, to occur, as well as gain insight into the non-linguistic cognitive functions that may play a role. Aims: This review of the literature aimed to (1) map the mechanisms of change that have been proposed or hypothesised within the PPA and AD lexical retrieval intervention literature to a theoretical framework based on a framework of motor recovery following stroke and accounts of change mechanisms within the post-stroke aphasia literature and explore whether particular mechanisms of change were associated with more effective outcomes; (2) determine whether particular mechanisms of change were associated with within- and across-level linguistic generalisation, and (3) investigate the role of non-linguistic cognitive functions in the lexical retrieval intervention studies reviewed here. Main Contribution: A search of Medline, PsycINFO, and CINAHL identified 37 papers published between 1982 and April 2016 that reported lexical retrieval intervention in people with PPA or AD, categorised here according to whether the proposed change mechanism was stimulation (12 studies), relearning (21 studies), reorganisation (three studies), or cognitive-relay (two studies). Significant treatment gains, predominantly based on linguistic performance measures, were reported for both diagnostic groups in association with the proposed mechanisms of stimulation and relearning. Significant treatment gains were also reported for people with PPA in association with reorganisation and cognitive-relay mechanisms; these mechanisms were only employed in PPA studies. Varying outcomes for linguistic generalisation were reported in 26 PPA and six AD studies. Nineteen studies incorporated non-linguistic cognitive functions in intervention; these were limited to autobiographical memory (17 studies), episodic memory (three studies), or both (one study). Conclusion: This review highlights that individuals with PPA and AD benefit from lexical retrieval intervention, irrespective of the mechanism of change, and that linguistic generalisation was reported in studies proposing different change mechanisms. Insufficient exploration of the role of non-linguistic cognitive functions was highlighted with respect to assessment, planning intervention, and interpreting intervention outcomes. Recommendations are made, with a view to heightening our ability to interpret intervention outcomes.