Jae Youn Cho
Korea University
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Featured researches published by Jae Youn Cho.
Tuberculosis and Respiratory Diseases | 2000
Young Hwan Kwon; Sang Yeup Lee; Sang Myeon Bak; Sin Hyung Lee; Chol Shin; Jae Youn Cho; Jae Jeong Shim; Kyung Ho Kang; Se Hwa Yoo; Kwang Ho In
Background : The dominant innervation of airway smooth muscle is parasympathetic fibers which are carried in the vagus nerve. Activation of these cholinergic nerves releases acetylcholine which binds to muscarinic receptors on the smooth muscle causing bronchocontraction. Acetylcholine also feeds back onto neuronal muscarinic receptors located on the postganglionic cholinergic nerves. Stimulation of these receptors further inhibits acetylcholine release, so these , muscarinic receptors act as autoreceptors. Loss of function of these receptors, as it occurs in animal models of hyperresponsiveness, leads to an increase in vagally mediated hyperresponsiveness. However, there are limited data pertaining to whether there are dysfunctions of these receptors in patients with asthma. The aim of this study is to determine whether there are dysfunction of muscarinic receptors in asthmatic patients and difference of function of these receptors according to severity of asthma. Method : We studied twenty-seven patients with asthma who were registered at Pulmonology Division of Korea University Hospital. They all met asthma criteria of ATS. Of these patients, eleven patients were categorized as having mild asthma, eight patients moderate asthma and eight patients severe asthma according to severity by NAEPP Expert Panel Report 2(1997). All subjects were free of recent upper respiratory tract infection within 2 weeks and showed positive methacholine challenge test ( muscarinic receptor agonist pilocarpine() through inhalation was performed be fore the routine procedures. Results : Eleven subjects with mild asthma and eight subjects with moderate asthma showed significant increase of from 5.305.23mg/ml(meanSD) to 20.8222.56mg/ml(p=0.004) and from 2.791.51mg/ml to 4.673.53mg/ml(p=0.012) after pilocarpine inhalation, respectively. However, in the eight subjects with severe asthma significant increase of from l.761.50mg/ml to 3.184.03mg/ml(p=0.161) after pilocarpine inhalation was not found. Conclusion : In subjects with mild and moderate asthma, function of muscarinic receptors was normal, but there was a dysfunction of these receptors in subjects with severe asthma. ηlese results suggest that function of muscarinic receptors is different according to severity of asthma.
Chest | 2001
Sang Yeub Lee; Jae Youn Cho; Jae Jeong Shim; Han Kyeom Kim; Kyung Ho Kang; Se Hwa Yoo; Kwang Ho In
Tuberculosis and Respiratory Diseases | 1998
Sin Hyung Lee; Jae Jeong Shim; Sang Youb Lee; Jae Youn Cho; Kwang Ho In; Se Hwa Yoo; Kyung Ho Kang
Tuberculosis and Respiratory Diseases | 2001
Sang Myeon Bak; Sang Hwa Lee; Sin Hyung Lee; Cheol Sin; Jae Youn Cho; Jae Jeong Shim; Kwang Ho In; Kyung Ho Kang; Se Hwa Yoo
Tuberculosis and Respiratory Diseases | 1999
Je Hyeong Kim; Kyung Kyu Kim; Hye Cheol Jeong; Sung Yong Lee; Young Hwan Kwon; So Ra Lee; Sang Youb Lee; Sin Hyung Lee; Dae Ryong Cha; Jae Youn Cho; Jae Joeng Shim; Won Yong Cho; Kyung Ho Kang; Hyoung Kyu Kim; Se Hwa Yoo; Kwang Ho In
Tuberculosis and Respiratory Diseases | 1996
Sin Gon Kim; Jin Yong Kim; Young Ho Lee; Jae Youn Cho; Han Kyeom Kim; Gwan Gyu Song
Tuberculosis and Respiratory Diseases | 1996
Sang Hwa Lee; So Ra Lee; Sang Youb Lee; Sang Muyn Park; Jung Kyung Suh; Jae Youn Cho; Jae Jeong Shim; Kwang Ho In; Se Hwa Yoo; Kyung Ho Kang
Tuberculosis and Respiratory Diseases | 2000
Sung Yong Lee; Sin Hyung Lee; Ki Hwan Jung; Byung Gyu Kim; Hae Chul Jung; Kyung Kyu Kim; Young Hwan Kwon; Je Hyeong Kim; Ju Han Lee; Sang Youb Lee; Jae Youn Cho; Jae Jeong Shim; Kwang Ho In; Se Hwa Yoo; Kyung Ho Kang
Tuberculosis and Respiratory Diseases | 1999
Sang Yeub Lee; Yu Whan Oh; Han Kyeom Kim; Bong Kyung Shin; Sang Myun Park; Sin Hyung Lee; Chol Shin; Jae Jeong Shim; Jae Youn Cho; Kyung Ho Kang; Se Hwa Yoo; Kwang Ho In
Tuberculosis and Respiratory Diseases | 1998
Jae Youn Cho; Kwang Ho In; Jung Kyung Suh; Sea Yong Kang; Jae Jeong Shim; Kyung Ho Kang; Se Hwa Yoo; Kwang Taek Kim; Cheol Yong Kim