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Dive into the research topics where Jae Youn Cho is active.

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Featured researches published by Jae Youn Cho.


Tuberculosis and Respiratory Diseases | 2000

Function of the neuronal M2 muscarinic receptor in asthmatic patients

Young Hwan Kwon; Sang Yeup Lee; Sang Myeon Bak; Sin Hyung Lee; Chol Shin; Jae Youn Cho; Jae Jeong Shim; Kyung Ho Kang; Se Hwa Yoo; Kwang Ho In

Background : The dominant innervation of airway smooth muscle is parasympathetic fibers which are carried in the vagus nerve. Activation of these cholinergic nerves releases acetylcholine which binds to muscarinic receptors on the smooth muscle causing bronchocontraction. Acetylcholine also feeds back onto neuronal muscarinic receptors located on the postganglionic cholinergic nerves. Stimulation of these receptors further inhibits acetylcholine release, so these , muscarinic receptors act as autoreceptors. Loss of function of these receptors, as it occurs in animal models of hyperresponsiveness, leads to an increase in vagally mediated hyperresponsiveness. However, there are limited data pertaining to whether there are dysfunctions of these receptors in patients with asthma. The aim of this study is to determine whether there are dysfunction of muscarinic receptors in asthmatic patients and difference of function of these receptors according to severity of asthma. Method : We studied twenty-seven patients with asthma who were registered at Pulmonology Division of Korea University Hospital. They all met asthma criteria of ATS. Of these patients, eleven patients were categorized as having mild asthma, eight patients moderate asthma and eight patients severe asthma according to severity by NAEPP Expert Panel Report 2(1997). All subjects were free of recent upper respiratory tract infection within 2 weeks and showed positive methacholine challenge test ( muscarinic receptor agonist pilocarpine() through inhalation was performed be fore the routine procedures. Results : Eleven subjects with mild asthma and eight subjects with moderate asthma showed significant increase of from 5.305.23mg/ml(meanSD) to 20.8222.56mg/ml(p=0.004) and from 2.791.51mg/ml to 4.673.53mg/ml(p=0.012) after pilocarpine inhalation, respectively. However, in the eight subjects with severe asthma significant increase of from l.761.50mg/ml to 3.184.03mg/ml(p=0.161) after pilocarpine inhalation was not found. Conclusion : In subjects with mild and moderate asthma, function of muscarinic receptors was normal, but there was a dysfunction of these receptors in subjects with severe asthma. ηlese results suggest that function of muscarinic receptors is different according to severity of asthma.


Chest | 2001

Airway Inflammation as an Assessment of Chronic Nonproductive Cough

Sang Yeub Lee; Jae Youn Cho; Jae Jeong Shim; Han Kyeom Kim; Kyung Ho Kang; Se Hwa Yoo; Kwang Ho In


Tuberculosis and Respiratory Diseases | 1998

The Protective Effect of Inhaled Heparin, Cromolyn, Budesonide, and Furosemide on Exercise-induced Asthma

Sin Hyung Lee; Jae Jeong Shim; Sang Youb Lee; Jae Youn Cho; Kwang Ho In; Se Hwa Yoo; Kyung Ho Kang


Tuberculosis and Respiratory Diseases | 2001

Clinical Study fo Pulmonary Thromboembolism

Sang Myeon Bak; Sang Hwa Lee; Sin Hyung Lee; Cheol Sin; Jae Youn Cho; Jae Jeong Shim; Kwang Ho In; Kyung Ho Kang; Se Hwa Yoo


Tuberculosis and Respiratory Diseases | 1999

Correlation Between Angiotensin-Converting Enzyme(ACE) Inhibitor Induced Dry Cough and ACE Gene Insertion/Deletion(I/D) Polymorphism

Je Hyeong Kim; Kyung Kyu Kim; Hye Cheol Jeong; Sung Yong Lee; Young Hwan Kwon; So Ra Lee; Sang Youb Lee; Sin Hyung Lee; Dae Ryong Cha; Jae Youn Cho; Jae Joeng Shim; Won Yong Cho; Kyung Ho Kang; Hyoung Kyu Kim; Se Hwa Yoo; Kwang Ho In


Tuberculosis and Respiratory Diseases | 1996

A Case of Bronchiolitis Obliterans Organizing Pneumonia anteceded by Rheumatoid Arthritis

Sin Gon Kim; Jin Yong Kim; Young Ho Lee; Jae Youn Cho; Han Kyeom Kim; Gwan Gyu Song


Tuberculosis and Respiratory Diseases | 1996

A comparative study of three therapeutic modalities in loculatedtuberculous pleural effusions

Sang Hwa Lee; So Ra Lee; Sang Youb Lee; Sang Muyn Park; Jung Kyung Suh; Jae Youn Cho; Jae Jeong Shim; Kwang Ho In; Se Hwa Yoo; Kyung Ho Kang


Tuberculosis and Respiratory Diseases | 2000

The Effects of Cyclooxygenase-2 (COX-2) Inhibitor on COX-2 and Prostaglandin E2 Expression in Ovalbumin Induced Early Phase Bronchoconstriction of Rats

Sung Yong Lee; Sin Hyung Lee; Ki Hwan Jung; Byung Gyu Kim; Hae Chul Jung; Kyung Kyu Kim; Young Hwan Kwon; Je Hyeong Kim; Ju Han Lee; Sang Youb Lee; Jae Youn Cho; Jae Jeong Shim; Kwang Ho In; Se Hwa Yoo; Kyung Ho Kang


Tuberculosis and Respiratory Diseases | 1999

A case of Nonspecific Interstitial Pneumonitis Mimicking Pneumoncystis carinii Pneumoni in HIV-positive patient

Sang Yeub Lee; Yu Whan Oh; Han Kyeom Kim; Bong Kyung Shin; Sang Myun Park; Sin Hyung Lee; Chol Shin; Jae Jeong Shim; Jae Youn Cho; Kyung Ho Kang; Se Hwa Yoo; Kwang Ho In


Tuberculosis and Respiratory Diseases | 1998

The Effects of High Dose Rate Brachytherapy in Recurrent Obstructive Bronchogenic Cancer after External Irradiation Therapy

Jae Youn Cho; Kwang Ho In; Jung Kyung Suh; Sea Yong Kang; Jae Jeong Shim; Kyung Ho Kang; Se Hwa Yoo; Kwang Taek Kim; Cheol Yong Kim

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